BACKGROUND Cold-inducible RNA-binding protein(CIRP)is related to a family of stressinduced RNA-binding proteins.It is primarily found in the nucleus,where it regulates transcription.Under stress,CIRP translocates to t...
supported by the National Natural Science Foundation of China(NSFC)Programs(22204046);the Hunan Science Fund for Excellent Young Scholars(2023JJ20002);the National Key Research Program(2019YFA0905800);the Changsha Municipal Natural Science Foundation(kq2402088);the Scientific Research Fund of Hunan Provincial Education Department(22B0874,23B0844).
Transcription factors(TFs)play vital roles in regulating gene expressions.Dysregulated or mutated TFs are implicated in a wide array of diseases,highlighting their potential as drug targets.However,TFs are considered ...
supported by the grants from the National Natural Science Foundation of China(Nos.81770407 and 31171097);the Key Project of Precision Medicine Joint Fund of Natural Science Foundation of Hebei Province(No.H2020206409);the College Students Innovative Pilot Project in Hebei Medical University(No.USIP2023011);the Science Fund for Creative Research Groups of Natural Science Foundation of Hebei Province(No.H2020206474).
Fibroblast growth factor(FGF)isoform 13,a distinct type of FGF,boasts significant potential for therapeutic intervention in cardiovascular dysfunctions.However,its impact on regulating fibrosis remains unexplored.This...
supported by the Biological Breeding-Major Projects (2023ZD04074);National Natural Science Foundation of China (32270433,32101205 and 32072045);Natural Science Foundation of Sichuan Province (2022NSFSC0143);supported by the NSF Plant Genome Research Program (IOS-2029889 and IOS-2132693)。
CRISPR-Cas12a genome engineering systems have been widely used in plant research and crop breeding.To date,the performance and use of anti-CRISPR-Cas12a systems have not been fully established in plants.Here,we conduc...
supported(as a PI,unless otherwise indicated)by one NIH R01 grant(#CA271915);by two Breakthrough Level 2 grants from the US DoD BCRP(#BC180476P1,#BC210945);by a grant from the STARR Cancer Consortium(#I16-0064);by a Transformative Breast Cancer Consortium Grant from the US DoD BCRP(#W81XWH2120034,PI:Formenti);by a U54 grant from NIH/NCI(#CA274291,PIs:Deasy,Formenti,Weichselbaum);by the 2019 Laura Ziskin Prize in Translational Research(#ZP-6177,PI:Formenti)from the Stand Up to Cancer(SU2C)Foundation;by a Mantle Cell Lymphoma Research Initiative(MCL-RI,PI:Chen-Kiang)grant from the Leukemia and Lymphoma Society(LLS);by a Rapid Response Grant from the Functional Genomics Initiative(New York,US);by a pre-SPORE grant(PIs:Demaria,Formenti);a Collaborative Research Initiative Grant and a Clinical Trials Innovation Grant from the Sandra and Edward Meyer Cancer Center(New York,US);by startup funds from the Dept.of Radiation Oncology at Weill Cornell Medicine(New York,US);by industrial collaborations with Lytix Biopharma(Oslo,Norway),Promontory(New York,US)and Onxeo(Paris,France);by donations from Promontory(New York,US);the Luke Heller TECPR2 Foundation(Boston,US),Sotio a.s.(Prague,Czech Republic);Lytix Biopharma(Oslo,Norway);Onxeo(Paris,France);Ricerchiamo(Brescia,Italy);Noxopharm(Chatswood,Australia).
TCDD-inducible poly(ADP-ribose)polymerase(TIPARP,best known as PARP7)has previously been shown to promote oncogenesis by limiting the cytosolic accumulation of potentially interferogenic nucleic acids in malignant cel...
Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in man...
National Natural Science Foundation of China(82172458,82371589,82073779,and 32000992);Natural Science Foundation of Zhejiang Province(Distinguished Young Scholar Program,No.LR21H300002,China).
Osteoarthritis(OA)is a type of highly prevalent heterogeneous degenerative disease that leads to joint pain,deformity,the destruction of articular cartilage,and eventual disability.The current treatment strategies for...
supported by the Grassland Ecological Restoration and Management Project of General Grassland Station of Xinjiang (XJCYZZ202102)。
Soil salinity is a wo rldwide issue and a major threat to global food security.Salinity tolerance is a complex mechanism that is conferred by numerous molecular,physiological,and biochemical traits.Of critical importa...
supported by Quanzhou City Science&Technology Program of China 455(2022NS056);the Science and Technology Department of Fujian Province(No.2024J01121794).
Objective The study aims to investigate the effects of interleukin-2-inducible T-cell kinase(ITK)on hepatitis B virus(HBV)-induced type I interferon(IFN)expression and the antiviral response.Methods Expression of ITK ...
[Objectives]To investigate the protective mechanism of naringenin on acute myocardial ischemia-reperfusion injury(AMI-RI)in Sprague-Dawley(SD)rats.[Methods]A total of 32 SD rats with AMI-RI model construction were ran...