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作品数：290被引量：772H指数：13
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相关作者：陈良凤段世明杨国栋周文华丑维斌更多>>
相关机构：南京大学滨州医学院湖南医科大学中国科学院上海生命科学研究院更多>>
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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease
《Neural Regeneration Research》2025年第8期2361-2372,共12页Shengyang Zhou Ting Li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen 
supported by the National Natural Science Foundation of China,Nos.82171429,81771384;a grant from Wuxi Municipal Health Commission,No.1286010241190480(all to YS)。
Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report tha...
关键词：cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease NEUROINFLAMMATION Parkinson’s disease RU521 STING type I interferon 
Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration
《Neural Regeneration Research》2025年第7期2005-2007,共3页Bryan Sun Lulin Li Jian Luo 
partially supported by a grant(RF1AG059694)from the U.S.National Institutes of Health;by Polytrauma System of Care,VAPAHCS(to JL)。
The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of neuroinflammation.While current studies primarily attribute its effects to neurons and glial ce...
关键词：STIMULATOR INTERFERON inflammation 
Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism
《World Journal of Gastrointestinal Oncology》2025年第3期202-220,共19页Ling Wu Hong-Yao Chen Jing-Ting Zhang Ren-Yi Yang Zhi-Bin Wang Pei-Sen Xue Wei Peng Ke-Xiong Li Wen-Hui Gao Pu-Hua Zeng 
the National Natural Science Foundation of China,No.82074425;Natural Foundation of Hunan Province,No.2023JJ30364 and No.2023JJ30361;Hunan Provincial Key R&D Program,No.2023SK2057;Key Project of Hunan Provincial Administration of Traditional Chinese Medicine,No.A2023042.
BACKGROUND Ferroptosis is an iron-dependent programmed non-apoptotic cell death characterized by the accumulation of free iron ions and lipid peroxidation.It is associated with the inactivation of glutathione peroxida...
关键词：Chlorogenic acid Hepatocellular carcinoma Ferroptosis Prostaglandin endoperoxide synthase 2/aldo-keto reductase family 1 member C3/glutathione peroxidase 4 axis BIOINFORMATICS In vitro experiment 
Metabolome and transcriptome association study reveals biosynthesis of specialized benzylisoquinoline alkaloids in Phellodendron amurense
《Chinese Herbal Medicines》2025年第1期178-188,共11页Tingxia Liu Wanran Zhang Sijia Wang Ya Tian Yifan Wang Ranran Gao Shilin Chen Wei Sun Wei Ma Zhichao Xu 
funded by grants from the National Key Research and Development Project“research and demonstration of collection,screening,and breeding technology of ginseng and other genuine medicinal materials”(No.2021YFD1600901);National Natural Science Foundation of China(No.82274037);Heilongjiang Touyan Innovation Team Program(No.HLJTYTP2019001)。
Objective:Benzylisoquinoline alkaloids(BIAs)have pharmacological functions and clinical use.BIAs are mainly distributed in plant species across the order Ranunculales and the genus Phellodendron from Sapindales.The BI...
关键词：benzylisoquinoline alkaloids BIOSYNTHESIS evolution norcoclaurine synthase Phellodendron amurense Rupr 
Cyclic GMP-AMP synthase recognizes the physical features of DNA
《Acta Pharmacologica Sinica》2025年第2期264-270,共7页Ling Dong Yue-ru Hou Na Xu Xiao-qian Gao Zhen Sun Qing-kai Yang Li-na Wang 
supported by grants from the National Natural Science Foundation of China(82173072).
Cyclic GMP-AMP synthase(cGAS)is a major cytosolic DNA sensor that plays a significant role in innate immunity.Upon binding to double stranded DNA(dsDNA),cGAS utilizes GTP and ATP to synthesize the second messenger cyc...
关键词：innate immune response cytosolic DNA sensor cyclic GMP-AMP synthase STING DNA physical features 
Bidirectional regulation of the cyclic guanosine monophosphateadenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma
《World Journal of Gastrointestinal Oncology》2025年第2期246-261,共16页Ai-Yu Nie Zhong-Hui Xiao Jia-Li Deng Na Li Li-Yuan Hao Sheng-Hao Li Xiao-Yu Hu 
Supported by the National Natural Science Foundation of China,No.81973840;the Sichuan Provincial Administration of Traditional Chinese Medicine Major Science and Technology projects,No.2021XYCZ004。
BACKGROUND Hepatocellular carcinoma(HCC)ranks as the fourth leading cause of cancerrelated deaths in China,and the treatment options are limited.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS...
关键词：Hepatocellular carcinoma Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene Interferon genes The metastasis of a tumor IMMUNOLOGY 
Induction of translation-suppressive G3BP1+stress granules and interferonsignaling cGAS condensates by transfected plasmid DNA
《hLife》2025年第1期21-37,共17页Vladimir Majerciak Zhi-Ming Zheng 
supported by the Intramural Research Program of the National Institutes of Health,the National Cancer Institute,and the Center for Cancer Research(ZIASC010357 to Z.M.Z.).
Plasmid DNA transfection is one of the fundamental tools of biomedical research.Here,we found that plasmid DNA transfection mediated by liposomes activates multiple innate immune responses in several widely used cell ...
关键词：plasmid DNA TRANSFECTION stress granules cyclic GMP-AMP synthase(cGAS) Kaposi’s sarcoma-associated herpesvirus(KSHV) protein kinase R(PKR) 
Sulfur metabolism under stress:Oxidized glutathione inhibits methionine biosynthesis by destabilizing the enzyme cystathionineγ-synthase
《Journal of Integrative Plant Biology》2025年第1期87-100,共14页Yael Hacham Alex Kaplan Elad Cohen Maayan Gal Rachel Amir 
supported by the Israel Science Foundation(ISF Grant no.1857/20);Binational Agricultural Research&Development(BARD Grant no.IS-4248-09 R)。
Cysteine is the precursor for the biosynthesis of glutathione,a key stress-protective metabolite,and methionine,which is imperative for cell growth and protein synthesis.The exact mechanism that governs the routing of...
关键词：cystathionineγ-synthase(CGS) CYSTEINE GLUTATHIONE metabolic competition METHIONINE oxidative stress sulfur metabolism TOBACCO 
cGAS-STING signaling pathway in lung cancer:Regulation on antitumor immunity and application in immunotherapy
《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第4期257-264,共8页Jing Wu Yingyao Chen Mengqing Xie Xin Yu Chunxia Su 
supported by the National Natural Science Foundation of China(Nos.82373320,82072568);the Shanghai Shenkang Hospital Development Center(No.SHDC12020110);the Shanghai Pulmonary Hospital Fund(No.fkzr2403);the National Key Research and Development Program of China(No.2023YFC2508603)。
The innate immune system has a primary role in defending against external threats,encompassing viruses,bac-teria,and fungi,thereby playing a pivotal role in establishing robust protection.Recent investigations have sh...
关键词：Cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING) Lung cancer Tumor microenvironment 
Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications
《World Journal of Diabetes》2024年第10期2041-2057,共17页Ming-Wei Fan Jin-Lan Tian Tan Chen Can Zhang Xin-Ru Liu Zi-Jian Zhao Shu-Hui Zhang Yan Chen 
Supported by the Natural Science Foundation of Shandong Province,No.ZR2022MH153;“Clinical+X”Project Fund of Binzhou Medical College,No.BY2021LCX11.
Diabetes mellitus(DM)is one of the major causes of mortality worldwide,with inflammation being an important factor in its onset and development.This review summarizes the specific mechanisms of the cyclic guanosine mo...
关键词：Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes Diabetes mellitus Inflammation Glycolipid metabolism Diabetes gastroenteropathy Nonalcoholic fatty liver disease Diabetes cardiovascular disease Diabetes nephropathy 
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