supported by the Intramural Research Program of the National Institutes of Health,the National Cancer Institute,and the Center for Cancer Research(ZIASC010357 to Z.M.Z.).
Plasmid DNA transfection is one of the fundamental tools of biomedical research.Here,we found that plasmid DNA transfection mediated by liposomes activates multiple innate immune responses in several widely used cell ...
BACKGROUND Mesenchymal stem cells(MSCs)are promising candidates for regenerative therapy due to their self-renewal capability,multilineage differentiation potential,and immunomodulatory effects.The molecular character...
National Health Commission Research Fund,No.WKJ-ZJ-2342;National Natural Science Foundation of China,No.81900583;Science and Technology Plan Project of Wenzhou,No.Y20180103.
BACKGROUND Acute pancreatitis(AP),the initially triggered inflammatory process in the pancreas,can be life-threatening.It has been reported that 15-lipoxygenase may promote the removal of damaged intracellular compone...
Different types of neuroendocrine cancer,including medullary thyroid cancer(MTC)and thyroid C-cell hyperplasia,are part of multiple endocrine neoplasia type 2(MEN2).A proto-oncogene mutation of the rearranged during t...
supported by the second batch of the China Drug Regulatory Science Action Plan(Research on safety and effectiveness evaluation of novel biomaterials)from National Medical Products Administration(NMPA).
Recombinant collagen is a pivotal topic in foundational biological research and epitomizes the application of critical bioengineer-ing technologies.These technological advancements have pro-found implications across d...
This work was supported by National Natural Science Funds of China(Nos.92059110 and 81872808);Development Fund for Shanghai Talents(No.2020090,China);Natural Science Foundation of Shanghai Science and Technology Innovation Plan(No.22ZR1414100,China);FDU 2025-Excellence Program Fund,Project Supported by Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01,China);ZJLab,Shanghai Post-doctoral Excellence Program(No.2033016,China);China Postdoctoral Science Foundation Funded Project(No.2023M730711).
Tumor vaccine is a promising strategy for cancer immunotherapy by introducing tumor antigens into the body to activate specific anti-tumor immune responses.Along with the technological breakthroughs in genetic enginee...
Objective:To assess the effect of cryopreservation on stemness and proliferation potential of sheep spermatogonial stem cells(SSCs)in vitro.Methods:Sheep testicular cells were isolated and putative SSCs were enriched ...
Supported by Natural Science Foundation of China(82160386);Guangxi Natural Science Foundation(2023GXNSFAA026189;2021GXNSFAA075042)。
[Objectives] To optimize the culture medium for head and neck squamous cell carcinoma patient-derived organoid and screen suitable cytokines;compare the transfection efficiency of direct transfection and short-term su...
supported by the National Natural Science Foundation of China, Nos.81971159(to LW), 81771317(to JFF)
Exosomes derived from bone marrow mesenchymal stem cells can inhibit neuroinflammation through regulating microglial phenotypes and promoting nerve injury repair.However,the underlying molecular mechanism remains uncl...
This work was supported by the Technology Fund of Guizhou Province(Qian ke he LH zi[2014]7576).
This work aimed to investigate the effects of calcitonin gene-related peptide(CGRP)-modified mesenchymal stem cells(MSCs)on vascular stenosis in carotid balloon-injured rats.The CGRP gene labeled with EGFP was transfe...