云南高校图书馆联盟文献共享服务平台- TARGETING

TARGETING: 作品数：1555被引量：5318H指数：27; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：张强刘发旺周梦洁杨小燕金晶更多>>; 相关机构：北京大学中国科学院第二军医大学南京大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Targeting the brain’s glymphatic pathway:A novel therapeutic approach for cerebral small vessel disease: 《Neural Regeneration Research》2026年第2期433-442,共10页Yuhui Ma Yan Han; supported by the National Natural Science Foundation of China,No.82274304(to YH);the Major Clinical Study Projects of Shanghai Shenkang Hospital Development Center,No.SHDC2020CR2046B(to YH);Shanghai Municipal Health Commission Talent Plan,No.2022LJ010(to YH).; Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological me...; 关键词：AQUAPORIN-4 ASTROCYTES cerebral amyloid angiopathy cerebral small vessel disease cerebrospinal fluid diffusion tensor image analysis along the perivascular space glymphatic system interstitial fluid perivascular space therapeutic strategies

Exosomes in neurodegenerative diseases:Therapeutic potential and modification methods: 《Neural Regeneration Research》2026年第2期478-490,共13页Hongli Chen Na Li Yuanhao Cai Chunyan Ma Yutong Ye Xinyu Shi Jun Guo Zhibo Han Yi Liu Xunbin Wei; supported by the National Natural Science Foundation of China,No.22103055(to JG);the Natural Science Foundation of Hebei Province,No.F2024110001(to HC);and Open Project of Tianjin Key Laboratory of Optoelectronic Detection Technology and System,Nos.2024LODTS215(to NL),2024LODTS216(to XS).; In recent years,exosomes have garnered extensive attention as therapeutic agents and early diagnostic markers in neurodegenerative disease research.Exosomes are small and can effectively cross the blood-brain barrier,...; 关键词：Alzheimer’s disease cell recognition central nervous system diseases enhanced targeting exosome modification exosome targeting neurodegenerative disease Parkinson’s disease stem cell exosomes stem cell therapy

Targeting Wallerian degeneration in glaucoma: 《Neural Regeneration Research》2026年第2期693-694,共2页Melissa Jöe Pete A.Williams; supported by St.Erik Eye Hospital philanthropic donations,Vetenskapsrådet 2022-00799(to PAW).; Neurodegenerative diseases account for a large and increasing health and economic burden worldwide.With an increasingly aged population,this burden is set to increase.Optic neuropathies make up a large proportion of n...; 关键词：health burden neurodegenerative diseases aged population Wallerian degeneration GLAUCOMA vision loss economic burden retinal ganglion cells their axons

Targeting Epac2 and GluA3-containing AMPARs:a novel therapeutic strategy for Alzheimer's disease: 《Neural Regeneration Research》2025年第11期3223-3224,共2页Tong Zhang Martina Schmidt; supported by Alzheimer Nederland grant[WE.03-2019-05](to MS)。; Alzheimer's disease(AD)is a neurodegenerative disease that manifests progressive decline in memory and cognition.In the early stage of AD,memory retrieval is impaired preceding memory acquisition and consolidation(Roy...; 关键词：ALZHEIMER IMPAIRED AΒ

Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases: 《Neural Regeneration Research》2025年第11期3076-3094,共19页Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi Yue Peng Luo; supported by the National Natural Science Foundation of China,Nos.82171363,82371381(to PL),82171458(to XJ);Key Research and Development Project of Shaa nxi Province,Nos.2024SF-YBXM-404(to KY)。; Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological diseases.Owing to their therapeutic properties and ability to cross the blood–b...; 关键词：Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles GLIOMA ischemic stroke neurological diseases Parkinson's disease PSYCHOSIS targeted drug delivery traumatic brain injury

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage: 《Neural Regeneration Research》2025年第9期2454-2463,共10页Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo; supported by MICIU(grant number PID2021-128133NB-100/AEI/FEDER10.13039/501100011033 to JMHG);by the National Institutes of Health(grant number R01 NS083858 to SAK);the Intramural Grants Program IGPP00057(to SAK);VIC enjoys a FPU contract from the Comunidad de Madrid(PIPF-2022/SAL-GL-25948)。; The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is well-documented.Nevertheless,the role of non-excitatory amino acids in brain damage following a stroke ...; 关键词：cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids STROKE synaptic transmission

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery: 《Neural Regeneration Research》2025年第8期2181-2198,共18页Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao; supported by the grants from University of Macao,China,Nos.MYRG2022-00221-ICMS(to YZ)and MYRG-CRG2022-00011-ICMS(to RW);the Natural Science Foundation of Guangdong Province,No.2023A1515010034(to YZ)。; Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent bioc...; 关键词：delivery engineering extracellular vesicles identification ischemic stroke isolation MITOCHONDRIA targeting strategy therapeutic effects

Developing mRNA Nanomedicines with Advanced Targeting Functions: 《Nano-Micro Letters》2025年第7期53-106,共54页Ji Wang Lijun Cai Ning Li Zhiqiang Luo Haozhen Ren Bing Zhang Yuanjin Zhao; supported by the National Key Research and Development Program of China(2022YFA1105304);the National Natural Science Foundation of China(T2225003 and 61927805);the Nanjing Medical Science and Technique Development Foundation(ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);the Jiangsu Funding Program for Excellent Postdoctoral Talent(2023ZB032);the Natural Science Foundation of Jiangsu Province(BK20240223);the Project of Institute of Chinese Medicine of Nanjing University(ICM2024011);the Aid Project of Nanjing Drum Tower Hospital Health,Education&Research Foundation.; The emerging messenger RNA(mRNA)nanomedicines have sprung up for disease treatment.Developing targeted mRNA nanomedicines has become a thrilling research hotspot in recent years,as they can be precisely delivered to s...; 关键词：MRNA Delivery system Targeted therapy DISEASES Precision medicine

Autophagy-targeting modulation to promote peripheral nerve regeneration: 《Neural Regeneration Research》2025年第7期1864-1882,共19页Yan Chen Hongxia Deng Nannan Zhang; supported by the National Natural Science Foundation of China,Nos.82271411(to RG),51803072(to WLiu);grants from the Department of Finance of Jilin Province,Nos.2022SCZ25(to RG),2022SCZ10(to WLiu),2021SCZ07(to RG);Jilin Provincial Science and Technology Program,No.YDZJ202201ZYTS038(to WLiu);The Youth Support Programmed Project of China-Japan Union Hospital of Jilin University,No.2022qnpy11(to WLuo);The Project of China-Japan Union Hospital of Jilin University,No.XHQMX20233(to RG)。; Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms.Past studies have focused on factors that stimulat...; 关键词：AUTOPHAGY autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy METFORMIN MYELINATION peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

Treating human cancer by targeting EZH2: 《Genes & Diseases》2025年第3期205-218,共14页Mengfei Xu Chunyan Xu Rui Wang Qing Tang Qichun Zhou Wanyin Wu Xinliang Wan Handan Mo Jun Pan Sumei Wang; supported by grants from the Research Fund for Bajian Talents of Guangdong Provincial Hospital of Chinese Medicine(China)(No.BJ2022KY13);the National Natural Science Foundation of China(No.82274602);the Foundation for Basic and Applied Research of Guangdong Province,China(No.2021A1515220023,2017B030314166);the Chinese Medicine Science and Technology Research Project of Guangdong Provincial Hospital of Chinese Medicine(China)(No.YN2019QJ06);the Guangzhou Science and Technology Plan Project(Guangdong,China)(No.2024A03J0548,202201020349);the Key Project of State Key Laboratory of Dampness Syndrome of Chinese Medicine Jointly Built by Province and Ministry(China)(No.SZ2021ZZ38);Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases(China)(No.YN2023MB09);the Guangdong Traditional Chinese Medicine Project(China)(No.20231094,20241135).; Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator that primarily inhibitsdownstream gene expression by tri-methylating histone H3, which is usually overexpressed intumors and participates in many processes s...; 关键词：CANCER Epigenetic modification EZH2 EZH2 inhibitor H3K27me3

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