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TARGETING: 作品数：1521被引量：5258H指数：26; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：张强刘发旺周梦洁杨小燕金晶更多>>; 相关机构：北京大学中国科学院第二军医大学南京大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Targeting Epac2 and GluA3-containing AMPARs:a novel therapeutic strategy for Alzheimer's disease: 《Neural Regeneration Research》2025年第11期3223-3224,共2页Tong Zhang Martina Schmidt; supported by Alzheimer Nederland grant[WE.03-2019-05](to MS)。; Alzheimer's disease(AD)is a neurodegenerative disease that manifests progressive decline in memory and cognition.In the early stage of AD,memory retrieval is impaired preceding memory acquisition and consolidation(Roy...; 关键词：ALZHEIMER IMPAIRED AΒ

Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases: 《Neural Regeneration Research》2025年第11期3076-3094,共19页Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi Yue Peng Luo; supported by the National Natural Science Foundation of China,Nos.82171363,82371381(to PL),82171458(to XJ);Key Research and Development Project of Shaa nxi Province,Nos.2024SF-YBXM-404(to KY)。; Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological diseases.Owing to their therapeutic properties and ability to cross the blood–b...; 关键词：Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles GLIOMA ischemic stroke neurological diseases Parkinson's disease PSYCHOSIS targeted drug delivery traumatic brain injury

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage: 《Neural Regeneration Research》2025年第9期2454-2463,共10页Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo; supported by MICIU(grant number PID2021-128133NB-100/AEI/FEDER10.13039/501100011033 to JMHG);by the National Institutes of Health(grant number R01 NS083858 to SAK);the Intramural Grants Program IGPP00057(to SAK);VIC enjoys a FPU contract from the Comunidad de Madrid(PIPF-2022/SAL-GL-25948)。; The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is well-documented.Nevertheless,the role of non-excitatory amino acids in brain damage following a stroke ...; 关键词：cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids STROKE synaptic transmission

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery: 《Neural Regeneration Research》2025年第8期2181-2198,共18页Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao; supported by the grants from University of Macao,China,Nos.MYRG2022-00221-ICMS(to YZ)and MYRG-CRG2022-00011-ICMS(to RW);the Natural Science Foundation of Guangdong Province,No.2023A1515010034(to YZ)。; Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent bioc...; 关键词：delivery engineering extracellular vesicles identification ischemic stroke isolation MITOCHONDRIA targeting strategy therapeutic effects

Autophagy-targeting modulation to promote peripheral nerve regeneration: 《Neural Regeneration Research》2025年第7期1864-1882,共19页Yan Chen Hongxia Deng Nannan Zhang; supported by the National Natural Science Foundation of China,Nos.82271411(to RG),51803072(to WLiu);grants from the Department of Finance of Jilin Province,Nos.2022SCZ25(to RG),2022SCZ10(to WLiu),2021SCZ07(to RG);Jilin Provincial Science and Technology Program,No.YDZJ202201ZYTS038(to WLiu);The Youth Support Programmed Project of China-Japan Union Hospital of Jilin University,No.2022qnpy11(to WLuo);The Project of China-Japan Union Hospital of Jilin University,No.XHQMX20233(to RG)。; Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms.Past studies have focused on factors that stimulat...; 关键词：AUTOPHAGY autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy METFORMIN MYELINATION peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia: 《Neural Regeneration Research》2025年第5期1397-1398,共2页Zhenyu Chen Xue-Jun Li; supported by the NIH grant(RO1 NS118066);the Blazer Foundation(to XJL)。; Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower extre...; 关键词：DEGENERATION DISEASES HEREDITARY

Inhibition of ITGA2 suppresses cervical tumorigenesis and metastasis by targeting the AKT/mTOR signaling pathway: 《Genes & Diseases》2025年第2期86-89,共4页Haixia Luo Jingjing Chang Yiting Ren Xiu Zhang Yuanxing Li Miao Huo Hongyuan Wang Xin Yang Jianbing Liu Qingmei Zhang Yueyang Zhao Wei Wang; supported by grants from the Applied Basic Research Program of Shanxi,China (No.20210302123277);the Key Research and Development Program of Shanxi,China (No.201903D321152);the National Natural Science Foundation of China (No.82373107).; Cervical cancer(CCa)is a substantial global health concern,and its lymph node metastasis(LNM)significantly diminishes patients'survival rates.1 Hence,a thorough investigation into the molecular mechanisms driving this...; 关键词：METASTASIS ITG cancer

Insights into targeting LKB1 in tumorigenesis: 《Genes & Diseases》2025年第2期154-170,共17页Charles B.Trelford Trevor G.Shepherd; Genetic alterations to serine-threonine kinase 11(STK11)have been implicated in Peutz-Jeghers syndrome and tumorigenesis.Further exploration of the context-specific roles of liver kinase B1(LKB1;encoded by STK11)obser...; 关键词：AMPK LKB1 Peutz-Jeghers syndrome STK11 Tumor suppressor

Exploring a novel mechanism for targeting β-arrestin-2 in the management of diabetic nephropathy: 《World Journal of Diabetes》2025年第4期1-7,共7页Na Liu Wei-Tao Yan Kun Xiong; Supported by National Natural Science Foundation of China,No.82303047,No.82372507,No.82172196 and No.32401046;Natural Science Foundation of Hunan Province,No.2022JJ40801。; Diabetic nephropathy(DN)is a well-known microvascular complication in patients with diabetes mellitus,which is characterized by the accumulation of extracellular matrix in the glomerular and tubulointerstitial compart...; 关键词：Diabetes mellitus Diabetic nephropathy β-arrestin-2 Endoplasmic reticulum stress ATF6 signaling pathway

Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy: 《International Journal of Oral Science》2025年第1期112-121,共10页Ming Hao Xingchen Li Xinxin Zhang Boqiang Tao He Shi Jianing Wu Yuyang Li Xiang Li Shuangji Li Han Wu Jingcheng Xiang Dongxu Wang Weiwei Liu Guoqing Wang; supported by the Science and Technology Projects of Jilin Provincial Department of Science and Technology(Grant/Award Numbers:20240305037YY);National Key Research and Development Program of China(2021YFC2400603);the Joint Funds of the National Natural Science Foundation of China(Grant No.U23A20269);the Jilin University young teachers and students cross-disciplinary training project(Grant No.2023-JCXK-08,2024-JCXK-07)。; Tongue squamous cell carcinoma(TSCC)is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion.Accurate diagnosis and effective treatment are essential for ...; 关键词：DIAGNOSIS SQUAMOUS INVASION

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