Developing mRNA Nanomedicines with Advanced Targeting Functions  

作　　者：Ji Wang Lijun Cai Ning Li Zhiqiang Luo Haozhen Ren Bing Zhang Yuanjin Zhao 

机构地区：[1]Department of Radiology,Nanjing Drum Tower Hospital,Medical School,Nanjing University,Nanjing 210008,People’s Republic of China [2]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,People’s Republic of China [3]Department of Hepatobiliary Surgery,Hepatobiliary Institute,Nanjing Drum Tower Hospital,Medical School,Nanjing University,Nanjing 210008,People’s Republic of China

出　　处：《Nano-Micro Letters》2025年第7期53-106,共54页纳微快报(英文版)

基　　金：supported by the National Key Research and Development Program of China(2022YFA1105304);the National Natural Science Foundation of China(T2225003 and 61927805);the Nanjing Medical Science and Technique Development Foundation(ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);the Jiangsu Funding Program for Excellent Postdoctoral Talent(2023ZB032);the Natural Science Foundation of Jiangsu Province(BK20240223);the Project of Institute of Chinese Medicine of Nanjing University(ICM2024011);the Aid Project of Nanjing Drum Tower Hospital Health,Education&Research Foundation.

摘　　要：The emerging messenger RNA(mRNA)nanomedicines have sprung up for disease treatment.Developing targeted mRNA nanomedicines has become a thrilling research hotspot in recent years,as they can be precisely delivered to specific organs or tissues to enhance efficiency and avoid side effects.Herein,we give a comprehensive review on the latest research progress of mRNA nanomedicines with targeting functions.mRNA and its carriers are first described in detail.Then,mechanisms of passive targeting,endogenous targeting,and active targeting are outlined,with a focus on various biological barriers that mRNA may encounter during in vivo delivery.Next,emphasis is placed on summarizing mRNA-based organtargeting strategies.Lastly,the advantages and challenges of mRNA nanomedicines in clinical translation are mentioned.This review is expected to inspire researchers in this field and drive further development of mRNA targeting technology.

关 键 词：MRNA Delivery system Targeted therapy DISEASES Precision medicine 

分 类 号：R943[医药卫生—药剂学]