AQUAPORIN-4

作品数：66被引量：218H指数：9
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相关领域：医药卫生更多>>
相关作者：沙洛林李红闪史彦芳郭毅马睿泽更多>>
相关机构：南京医科大学中山大学附属第三医院河北大学北华大学更多>>
相关期刊：《Chinese Journal of Traumatology》《Acta Pharmacologica Sinica》《Clinical Research Communications》《International Journal of Ophthalmology(English edition)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金北京市自然科学基金更多>>
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Targeting the brain’s glymphatic pathway:A novel therapeutic approach for cerebral small vessel disease
《Neural Regeneration Research》2026年第2期433-442,共10页Yuhui Ma Yan Han 
supported by the National Natural Science Foundation of China,No.82274304(to YH);the Major Clinical Study Projects of Shanghai Shenkang Hospital Development Center,No.SHDC2020CR2046B(to YH);Shanghai Municipal Health Commission Talent Plan,No.2022LJ010(to YH).
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological me...
关键词：AQUAPORIN-4 ASTROCYTES cerebral amyloid angiopathy cerebral small vessel disease cerebrospinal fluid diffusion tensor image analysis along the perivascular space glymphatic system interstitial fluid perivascular space therapeutic strategies 
Measuring glymphatic function:Assessing the toolkit
《Neural Regeneration Research》2026年第2期534-541,共8页Koushikk Ayyappan Lucas Unger Philip Kitchen Roslyn MBill Mootaz MSalman 
supported by the European Union Horizon 2020 Research and Innovation Programme(Marie Skłodowska-Curie grant agreement No 847419);supported by the Biotechnology and Biological Sciences Research Council via a Discovery Fellowship(BB/W00934X/1);the Aston University RKE Pump Priming Programme;funded by UKRI’s Research England as part of their Expanding Excellence in England(E3)fund;supported by a UKRI Frontier Research Grant EP/Y023684/1(following assessment as an ERC Advanced grant,FORTIFY,ERC-2022-ADG-101096882 under the UK Government Guarantee scheme)and acknowledged a Biotechnology and Biological Sciences Research Council Pioneer Award(BB/Y512874/1).MMS was supported by a Medical Research Council Career Development Award(MR/W027119/1);acknowledged support from the BHF Centre of Research Excellence,University of Oxford(grant code:RE/24/130024);a Biotechnology and Biological Sciences Research Council Pioneer Award(BB/Y512874/1).
Glymphatic flow has been proposed to clear brain waste while we sleep.Cerebrospinal fluid moves from periarterial to perivenous spaces through the parenchyma,with subsequent cerebrospinal fluid drainage to dural lymph...
关键词：AQUAPORIN-4 cerebrospinal fluid EFFLUX glymphatics imaging INFLUX methods microfluidics PARENCHYMA periarterial perivenous TRACER 
Targeting the glymphatic system to promoteα-synuclein clearance:a novel therapeutic strategy for Parkinson's disease
《Neural Regeneration Research》2026年第1期233-247,共15页Xiaoyue Lian Zhenghao Liu Zuobin Gan Qingshan Yan Luyao Tong Linan Qiu Yuntao Liu Jiang-fan Chen Zhihui Li 
supported by the National Natural Science Foundation of China,No.81971031(to ZL);the National Key Research and Development Program of China,No.2022YFE0210100(to JFC);the National Natural Science Foundation of China(Original Exploration Project),No.82151308(to JFC);the National Natural Science Foundation of China(Research Fund for International Senior Scientists),No.82150710558(to JFC);Science&Technology Initiative STI2030-Major Projects,No.2021ZD0203400(to JFC);Key Research and Development Program of Zhejiang Province,No.2023C03079(to JFC);Scientific Research Starting Foundation of Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine,Vision and Brain Health),No.OJQDSP2022007(to JFC);Project of State Key Laboratory of Ophthalmology,Optometry and Visual Science,Wenzhou Medical University,No.J01-20190101(to JFC);Scientific Research Starting Foundation of Wenzhou Medical University,No.QTJ12003(to JFC);Department of Science and Technology of Zhejiang Province,No.2023ZY1011(to JFC)。
The excessive buildup of neurotoxicα-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease,highlighting the urgent need for innovative therapeutic strategies to promoteα-synuclein clearance,parti...
关键词：AQUAPORIN-4 ASTROCYTES cerebrospinal fluid glymphatic system interstitial fluid neurotoxic protein clearance Parkinson's disease perivascular spaces sleep disturbance Α-SYNUCLEIN 
Functional abnormalities of the glymphatic system in cognitive disorders
《Neural Regeneration Research》2025年第12期3430-3447,共18页Wuyue Shentu Qi Kong Yier Zhang Wenyao Li Qiulu Chen Sicheng Yan Junjun Wang Qilun Lai Qi Xu Song Qiao 
supported by Zhejiang Provincial Medical and Health Science and Technology Project,Nos.2022KY008(to JW),2023KY001(to JW),2023KY006(to QL);Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project,No.2023ZL220(to QL)。
Various pathological mechanisms represent distinct therapeutic targets for cognitive disorders,but a balance between clearance and production is essential for maintaining the stability of the brain's internal environm...
关键词：AQUAPORIN-4 ASTROCYTE cerebrospinal fluid dynamics cognitive disorders glymphatic system 
Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2
《Neural Regeneration Research》2025年第6期1801-1815,共15页Qing He Zhen Wang Yuchen Wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu Gong Chen 
supported by the Key Project of Guangzhou City,No.202206060002;Science and Technology Project of Guangdong Province,No.2018B030332001;Guangdong Provincial Pearl River Project,No.2021ZT09Y552 (all to GC)。
Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders....
关键词：AQUAPORIN-4 Ascl1 ASTROCYTE cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 REPROGRAMMING 
Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis
《Neural Regeneration Research》2025年第2期354-365,共12页Li Xu Huiming Xu Changyong Tang 
Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism rem...
关键词：AQUAPORIN-4 experimental model neuromyelitis optica spectrum disorder PATHOGENESIS 
Biomarkers for neuromyelitis optica:a visual analysis of emerging research trends被引量：3
《Neural Regeneration Research》2024年第12期2735-2749,共15页Xiangjun Li Jiandong Zhang Siqi Zhang Shengling Shi Yi’an Lu Ying Leng Chunyan Li 
Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system that differs from multiple sclerosis.Over the past 20 years,the search for biomarke rs for neuromyelitis optica has been ongo...
关键词：AQUAPORIN-4 AUTOANTIBODY multiple sclerosis myelin oligodendrocyte glycoprotein antibody-associated disease neuromyelitis optica neuromyelitis optica spectrum disorder optical coherence tomography 
Glymphatic system:a gateway for neuroinflammation被引量：1
《Neural Regeneration Research》2024年第12期2661-2672,共12页Kailu Zou Qingwei Deng Hong Zhang Changsheng Huang 
supported by the National Natural Science Foundation of China,Nos.82071249 and 81771207 (both to CH)。
The glymphatic system is a relatively recently identified fluid exchange and transpo rt system in the brain.Accumulating evidence indicates thatglymphatic function is impaired not only in central nervous system disord...
关键词：AQUAPORIN-4 central nervous system disease cerebrospinal fluid chronic neuroinflammation glymphatic dysfunction NEURODEGENERATION peripheral nerve injury perivascular space systemic disease vicious cycle 
The Regulatory Role and Mechanism of Circadian Rhythm in Hemoglobin Co-cultured Neurovascular Unit
《Biomedical and Environmental Sciences》2024年第7期726-738,共13页Fang Xue Wenchao Chen Xia Lian Guanghui He Jingyuan Tian Yinghong Liu Gaiqing Wang 
supported by the National Natural Science Foundation of China(No.82160237);the Key Research and Development Program in Hainan Province(No.ZDYF2023SHFZ104);Natural Science Foundation of Hainan Province(No.822MS210).
Objective Intracranial hemorrhage(ICH),the second most common subtype of stroke,exacerbates the disruption of the blood-brain barrier(BBB),leading to vasogenic edema,plasma protein extravasation,and infiltration of ne...
关键词：Blood-brain barrier Circadian rhythm Neurovascular unit Melatonin receptor 1A AQUAPORIN-4 
Anti-aquaporin-4 antibody(AQP4-IgG)and anti-myelin oligodendrocyte glycoprotein antibody(MOG-IgG)in the cerebrospinal fluid被引量：1
《Neural Regeneration Research》2024年第5期949-950,共2页Tetsuya Akaishi Tatsuro Misu 
In the last decade,a new neurological disease concept known as anti-myelin oligodendrocyte glycoprotein antibody(MOG-IgG)-associated disease(MOGAD)has emerged and is currently one of the most focused research areas in...
关键词：AQP4 MYELIN 
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