Glymphatic system:a gateway for neuroinflammation  

作　　者：Kailu Zou Qingwei Deng Hong Zhang Changsheng Huang 

机构地区：[1]Department of Anesthesiology,Xiangya Hospital,Central South University,Changsha,Hunan Province,China [2]Xiangya School of Medicine,Central South University,Changsha,Hunan Province,China [3]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan Province,China

出　　处：《Neural Regeneration Research》2024年第12期2661-2672,共12页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82071249 and 81771207 (both to CH)。

摘　　要：The glymphatic system is a relatively recently identified fluid exchange and transpo rt system in the brain.Accumulating evidence indicates thatglymphatic function is impaired not only in central nervous system disorders but also in systemic diseases.Systemic diseases can trigger the inflammatory responses in the central nervous system,occasionally leading to sustained inflammation and functional disturbance of the central nervous system.This review summarizes the current knowledge on the association between glymphatic dysfunction and central nervous system inflammation.In addition,we discuss the hypothesis that disease conditions initially associated with peripheral inflammation ove rwhelm the performance of the glymphatic system,thereby triggering central nervous system dysfun ction,chronic neuroinflammation,and neurodegeneration.Future research investigating the role of the glymphatic system in neuroinflammation may offer innovative therapeutic approaches for central nervous system disorders.

关 键 词：AQUAPORIN-4 central nervous system disease cerebrospinal fluid chronic neuroinflammation glymphatic dysfunction NEURODEGENERATION peripheral nerve injury perivascular space systemic disease vicious cycle 

分 类 号：R741[医药卫生—神经病学与精神病学]