IMMORTALIZATION

作品数：33被引量：130H指数：6
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Immortalization of epidural fat-derived mesenchymal stem cells: In vitro characterization and adipocyte differentiation potential
《World Journal of Stem Cells》2025年第1期40-52,共13页Seoung-Woo Lee Young-Ju Lim Hee-Yeon Kim Wansoo Kim Wook-Tae Park Min-Jung Ma Junho Lee Min-Soo Seo Young In Kim Sangbum Park Seong-Kyoon Choi Gun Woo Lee 
BACKGROUND Mesenchymal stem cells(MSCs)are promising candidates for regenerative therapy due to their self-renewal capability,multilineage differentiation potential,and immunomodulatory effects.The molecular character...
关键词：IMMORTALIZATION TRANSFECTION Stem cell Epidural fat Proteomics 
Establishment of immortalized rabbit bone marrow mesenchymal stem cells and a preliminary study of their osteogenic differentiation capability
《Animal Models and Experimental Medicine》2024年第6期824-834,共11页Yao Zhang Chang Xu Yun Huang Dongmei Tan Wenping Luo Yan Zhang Yi Tan 
Background:A stable and standardized source of mesenchymal stem cells is a prerequisite for bone repair tissue engineering research and application.We aimed to establish a stable cell line of bone marrow mesenchymal s...
关键词：bone marrow mesenchymal stem cells bone morphogenetic protein 9 GelMA hydrogel IMMORTALIZATION 
Immortalized hippocampal astrocytes from 3xTg-AD mice,a new model to study disease-related astrocytic dysfunction:a comparative review被引量：1
《Neural Regeneration Research》2023年第8期1672-1678,共7页Laura Tapella Giulia Dematteis Armando A Genazzani Massimiliano De Paola Dmitry Lim 
supported by fellowship to a grant from CRT Foundation,No.1393-2017(to LT);grants from the Fondazione Cariplo,Nos.2013-0795(to AAG),2014-1094(to DL);grants from The Universitàdel Piemonte Orientale,Nos.FAR-2016(to DL),FAR-2019(to DL)。
Alzheimer's disease(AD)is characterized by complex etiology,long-lasting pathogenesis,and celltype-specific alterations.Currently,there is no cure for AD,emphasizing the urgent need for a comprehensive understanding o...
关键词：Alzheimer's disease astrocytes immortalization astroglial Alzheimers's disease model blood-brain barrier calcium signaling central nervous system homeostasis disproteostasis endoplasmic reticulum-mitochondria contacts induced pluripotent stem cell-derived astrocytes protein synthesis 
SV40 large T antigen-induced immortalization reprograms mouse cardiomyocyte progenitors with mesenchymal stem cell characteristics and osteogenic potential被引量：3
《Genes & Diseases》2023年第4期1161-1164,共4页Yichun Yu Jiamin Zhong Connie Chen Yannian Gou Guozhi Zhao Piao Zhao Yonghui Wang Wei Zeng Annie Wang William D.Wagstaff Jr Rex C.Haydon Tong-Chuan He Russell R.Reid Michael J.Lee Hue H.Luu Jiaming Fan 
supported in part by research grants from the National Institutes of Health(No.CA226303 to T.C.H.,No.DE030480 to R.R.R.).;supported in part by research grants from the 2019 Science and Technology Research Plan Project of the Chongqing Education Commission(China)(No.KJQN201900410);the 2019 Funding for Postdoctoral Research(Chongqing Human Resources and Social Security Bureau No.298);the Natural Science Foundation of China(No.82102696);supported by the Medical Scientist Training Program of the National Institutes of Health(No.T32 GM007281).
While progenitor cell-based cardiomyocyte regeneration holds great promise of repairing an injured heart,primary cardiomyogenic progenitors(CPs)have a limited life span in culture,hampering the use of CPs for in vitro...
关键词：PROGENITOR cardio potential 
Telomerase-mediated immortalization of human vaginal wall fibroblasts derived from patients with pelvic organ prolapse
《Chinese Medical Journal》2023年第5期578-587,共10页Tao Guo Ting Xie Jinghe Lang Zhijing Sun 
National Natural Science Foundation of China(No.81971366);Beijing Natural Science Foundation(No.Z190021);CAMS Innovation Fund for Medical Sciences(No.CIFMS 2020-I2M-C&T-B-043)
Background: Extracellular matrix (ECM) remodeling is the most important pathomechanism of pelvic organ prolapse (POP). Fibroblasts are the key to ECM regulation. The passaging capacity of human vaginal wall fibroblast...
关键词：Pelvic organ prolapse FIBROBLASTS Telomere shortening Cellular senescence 
Reversibly immortalized keratinocytes(iKera)facilitate re-epithelization and skin wound healing:Potential applications in cell-based skin tissue engineering被引量：4
《Bioactive Materials》2022年第3期523-540,共18页Jiamin Zhong Hao Wang Ke Yang Huifeng Wang Chongwen Duan Na Ni Liqin An Yetao Luo Piao Zhao Yannian Gou Shiyan Sheng Deyao Shi Connie Chen William Wagstaff b Bryce Hendren-Santiago b Rex C.Haydon b Hue H.Luu b Russell R.Reid Sherwin HHo Guillermo A.Ameer Le Shen Tong-Chuan He Jiaming Fan 
The reported study was supported in part by research grants from the 2019 Chongqing Support Program for Entrepreneurship and Innovation(No.cx2019113)(JF);the 2019 Science and Technology Research Plan Project of Chongqing Education Commission(KJQN201900410)(JF);the 2019 Youth Innovative Talent Training Program of Chongqing Education Commission(No.CY200409)(JF);the 2019 Funding for Postdoctoral Research(Chongqing Human Resources and Social Security Bureau No.298)(JF)and the National Key Research and Development Program of China(2016YFC1000803);RRR,TCH and GAA were partially funded by the National Institutes of Health(DE030480);WW was supported by the Medical Scientist Training Program of the National Institutes of Health(T32 GM007281);This project was also supported in part by The University of Chicago Cancer Center Support Grant(P30CA014599);the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1 TR000430;TCH was also supported by the Mabel Green Myers Research Endowment Fund,The University of Chicago Orthopaedics Alumni Fund,and The University of Chicago SHOCK Fund.Funding sources were not involved in the study design;in the collection,analysis and/or interpretation of data;in the writing of the report;or in the decision to submit the paper for publication.
Skin injury is repaired through a multi-phase wound healing process of tissue granulation and re-epithelialization.Any failure in the healing process may lead to chronic non-healing wounds or abnormal scar formation.A...
关键词：KERATINOCYTES Skin tissue engineering Reversible immortalization SV40 large T antigen PPCN Skin wound healing 
Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs)被引量：4
《Genes & Diseases》2021年第6期814-826,共13页Xiaoxing Wu Zhaoxia Li Hongyu Zhang Fang He Min Qiao Huaxiu Luo Jing Zhang Meng Zhang Yukun Mao William Wagstaff Yongtao Zhang Changchun Niu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Rex C.Haydon Russell R.Reid Hue H.Luu Tong-Chuan He Ziwei Wang Houjie Liang Bing-Qiang Zhang Ning Wang 
Intestinal cancers are developed from intestinal epithelial stem cells(ISCs)in intestinal crypts through a multi-step process involved in genetic mutations of oncogenes and tumor suppressor genes.ISCs play a key role ...
关键词：Cancer modeling Conditional immortalization Mini-gut organoids Mouse intestinal crypt(MIC)cells Tumorigenesis 
Establishment of cell lines with porcine spermatogonial stem cell properties被引量：4
《Journal of Animal Science and Biotechnology》2020年第3期678-689,共12页Yi Zheng Tongying Feng Pengfei Zhang Peipei Lei Fuyuan Li Wenxian Zeng 
This study was supported by the National Natural Science Foundation of China(Grant No.31572401,31772605)to W.Z.;the Open Fund of Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province(Grant No.SNDK-KF-201804);Young Talent fund of University Association for Science and Technology in Shaanxi,China(Grant No.20180204)and a startup fund from Northwest A&F University(Grant No.2452018037)to Y.Z.
Background:Spermatogonial stem cells(SSCs)are capable of both self-renewal and differentiation to mature functional spermatozoa,being the only adult stem cells in the males that can transmit genetic information to the...
关键词：IMMORTALIZATION PIG SELF-RENEWAL Spermatogonial stem cells SV40 large T antigen 
Diffuse Intrinsic Pontine Gliomas Exhibit Cell Biological and Molecular Signatures of Fetal Hindbrain-Derived Neural Progenitor Cells被引量：2
《Neuroscience Bulletin》2019年第2期216-224,共9页Yu Sun Cheng Xu Changcun Pan Xin Chen Yibo Geng Yuliang Wu Peng Zhang Wenhao Wu Yu Wang Deling Li Zhen Wu Junting Zhang Qiaoran Xi Liwei Zhang 
supported by Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201608);the Beijing Municipal Natural Science Foundation (7161004)
Diffuse intrinsic pontine glioma(DIPG) is the main cause of brain tumor-related death among children.Until now, there is still a lack of effective therapy with prolonged overall survival for this disease. A typical st...
关键词：Diffuse intrinsic PONTINE GLIOMA Neural PROGENITOR cells IMMORTALIZATION H3K27M SENESCENCE 
Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes(imPODs)被引量：6
《Genes & Diseases》2018年第2期137-149,共13页Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang Yixiao Feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C.Haydon Hue H.Luu Tong-Chuan He Hua Gan 
The reported work was supported in part by research grants from the National Institutes of Health(CA226303 to TCH);the National Key Research and Development Program of China(2016YFC1000803 and 2011CB707906 to TCH);This project was also supported in part by The University of Chicago Cancer Center Support Grant(P30CA014599);the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1 TR000430.
Glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of kidney.Maintaining the viability and structura...
关键词：Chronic kidney disease FLP recombinase Glomerular disease GLOMERULUS IMMORTALIZATION NEPHROPATHY PODOCYTE SV40 T antigen 
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