SELF-RENEWAL

作品数：101被引量：591H指数：12
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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases
《Neural Regeneration Research》2025年第6期1582-1598,共17页Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia 
supported by the Natural Science Foundation of Heilongjiang Province of China,Outstanding Youth Foundation,No.YQ2022H003 (to DW)。
N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis a...
关键词：Alzheimer's disease cell self-renewal central nervous system MEMORY MICROGLIA nerve regeneration neurodegenerative diseases NEUROGENESIS RNA methylation 
DNA methyltransferase 1/miR-342-3p/Forkhead box M1 signaling axis promotes self-renewal in cervical cancer stem-like cells in vitro and nude mice models
《World Journal of Stem Cells》2025年第3期44-64,共21页Xiao-Zheng Cao Yao-Feng Zhang Yu-Wei Song Lei Yuan Hui-Li Tang Jin-Yuan Li Ye-Bei Qiu Jia-Zhi Lin Ying-Xia Ning Xiao-Yu Wang Yong Xu Shao-Qiang Lin 
Supported by Guangzhou Basic and Applied Basic Research Foundation,No.202201010121;Medical Joint Fund of Jinan University,No.YXZY2024014 and No.YXJC2022001;Hospital Achievement Transformation and Cultivation Project,No.ZH201911;the Key Discipline Project of Guangdong Province,No.2019-GDXK-0016;and the Medical Science and Technology Research Foundation of Guangdong Province,No.B2021145.
BACKGROUND Cervical cancer(CC)stem cell-like cells(CCSLCs),defined by the capacity of differentiation and self-renewal and proliferation,play a significant role in the progression of CC.However,the molecular mechanism...
关键词：DNA methyltransferase 1 Cancer stem cell Cervical cancer MiR-342-3p Forkhead box M1 
Forkhead box O proteins:steering the course of stem cell fate
《Cell Regeneration》2024年第1期315-337,共23页Mengdi Cheng Yujie Nie Min Song Fulin Chen Yuan Yu 
National Natural Science Foundation of China(31900330);Natural Science Basic Research Plan in Shaanxi Province of China(2024JC-YBMS-182).
Stem cells are pivotal players in the intricate dance of embryonic development,tissue maintenance,and regenera-tion.Their behavior is delicately balanced between maintaining their pluripotency and differentiating as n...
关键词：Stem cell fate SELF-RENEWAL QUIESCENCE Differentiation FOXO 
p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells
《Protein & Cell》2024年第11期840-857,共18页Nini Wang Shangda Yang Yu Li Fanglin Gou Yanling Lv Xiangnan Zhao Yifei Wang Chang Xu Bin Zhou Fang Dong Zhenyu Ju Tao Cheng Hui Cheng 
supported by grants from the Ministry of Science and Technology of China(2021YFA1100900,2020YFE0203000,2021YFA1100103);the National Natural Science Foundation of China(92368202,82270120,82222004,82230047);the Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00016);the CAMS Initiative for Innovative Medicine(2021-I2M-1-019 and 2022-I2M-2-001);the CAMS Fundamental Research Funds for Central Research Institutes(3332021093);the Distinguished Young Scholars of Tianjin(23JCJQJC00220).
The maintenance of hematopoietic stem cells(HSCs)is a complex process involving numerous cell-extrinsic and-intrinsic regulators.The first member of the cyclin-dependent kinase family of inhibitors to be identified,p2...
关键词：hematopoietic stem cells SELF-RENEWAL P21 Zbtb18 cKit 
Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells
《World Journal of Stem Cells》2024年第5期551-559,共9页Amani Yehya Joseph Azar Mohamad Al-Fares Helene Boeuf Wassim Abou-Kheir Dana Zeineddine Ola Hadadeh 
Supported by the National Council for Scientific Research in Lebanon,CNRS-L.
BACKGROUND Embryonic stem cells(ESCs)serve as a crucial ex vivo model,representing epiblast cells derived from the inner cell mass of blastocyst-stage embryos.ESCs exhibit a unique combination of self-renewal potency,...
关键词：Mouse embryonic stem cells SELF-RENEWAL Apoptosis Cardiac differentiation B-cell lymphoma 2 PIM-2 Metallothionein-1 
Maintenance of stem cell self-renewal by sex chromosomal zincfinger transcription factors
《World Journal of Methodology》2024年第4期23-29,共7页Katsuhiro Kita Celine Morkos Kathleen Nolan 
In this Editorial review,we would like to focus on a very recent discovery showing the global autosomal gene regulation by Y-and inactivated X-chromosomal transcription factors,zinc finger gene on the Y chromosome(ZFY...
关键词：ZFX ZFY SELF-RENEWAL Stem cell Sex chromosome regulators 
OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility
《Research》2024年第1期455-469,共15页Yinghong Cui Wei Chen Li Du Zuping He 
the grants from the National Nature Science Foundation of China(32170862 and 31872845);Major Scientific and Technological Projects for Collaborative Prevention and Control of Birth Defect in Hunan Province(2019SK1012);Key Grant of Research and Development in Hunan Province(2020DK2002);Developmental Biology and Breeding(2022XKQ0205);Natural Science Foundation of Hunan Province of China(2020JJ5380,2020JJ5383,and 2021JJ40365);a grant from the Shanghai Key Laboratory of Reproductive Medicine.
Spermatogonial stem cells(SSCs)have important applications in both reproduction and regenerative medicine.Nevertheless,specific genes and signaling transduction pathways in mediating fate decisions of human SSCs remai...
关键词：OIP5 APOPTOSIS reversed 
The transcriptional activator Klf5 recruits p300-mediated H3K27ac for maintaining trophoblast stem cell pluripotency
《Journal of Molecular Cell Biology》2023年第7期31-44,共14页Chengli Dou Linhui Wu Jingjing Zhang Hainan He Tian Xu Zhisheng Yu Peng Su Xia Zhang Junling Wang Yi-Liang Miao Jilong Zhou 
This work was supported by the National Natural.Science Foundation of China(31970822 and 31902161);the Key Research and Development Program of Hubei Province(2021BBA221 and 2022BCE002);the Fundamental Research Funds for the Central Universities(2662022DKPY001);the Major Project of Hubei Hongshan Laboratory(2021hszdo03)。
The effective proliferation and differentiation of trophoblast stem cells(TSCs)is indispensable for the development of the placenta,which is the key to maintaining normal fetal growth during pregnancy.Kruppel-like fac...
关键词：Klf5 trophoblast stem cells SELF-RENEWAL chromatin accessibility P300 H3K27ac 
Zinc enhances the cell adhesion,migration,and self-renewal potential of human umbilical cord derived mesenchymal stem cells被引量：2
《World Journal of Stem Cells》2023年第7期751-767,共17页Iqra Sahibdad Shumaila Khalid G Rasul Chaudhry Asmat Salim Sumreen Begum Irfan Khan 
Supported by Higher Education Commission,Pakistan indigenous fellowship,No.520-149004-2MD6-75(to Ms.Iqra Sahibdad)and No.520-165117-2BS6-21(to Ms.Shumaila Khalid).
BACKGROUND Zinc(Zn)is the second most abundant trace element after Fe,present in the human body.It is frequently reported in association with cell growth and proliferation,and its deficiency is considered to be a majo...
关键词：Human umbilical cord Mesenchymal stem cells ZINC Cell proliferation In vitro expansion 
TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal被引量：3
《Cellular & Molecular Immunology》2023年第2期158-174,共17页Jing Wang Dongdong Zhao Zehui Lei Pupu Ge Zhe Lu Qiyao Chai Yong Zhang Lihua Qiang Yang Yu Xinwen Zhang Bingxi Li Shu Zhu Lingqiang Zhang Cui Hua Liu 
supported by the National Key Research and Development Project of China(2021YFA1300200 to CHL and LZ,2022YFC2302900 to CHL and JW);the National Natural Science Foundation of China(81825014 to CHL,31830003 to CHL,82022041 to JW and 81871616 to JW);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29020000 to CHL);Youth Innovation Promotion Association CAS(2018118 to JW);the State Key Laboratory of Proteomics(SKLP-K202001 to LZ and SKLPO202003 to JW).
Dysregulation of gut homeostasis is associated with irritable bowel syndrome(IBS),a chronic functional gastrointestinal disorder affecting approximately 11.2%of the global population.The poorly understood pathogenesis...
关键词：TRIM27 Wnt/β-catenin signaling ISC self-renewal IBS 
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