QUIESCENCE

作品数：43被引量：80H指数：4
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相关机构：中国医学科学院北京大学更多>>
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Forkhead box O proteins:steering the course of stem cell fate
《Cell Regeneration》2024年第1期315-337,共23页Mengdi Cheng Yujie Nie Min Song Fulin Chen Yuan Yu 
National Natural Science Foundation of China(31900330);Natural Science Basic Research Plan in Shaanxi Province of China(2024JC-YBMS-182).
Stem cells are pivotal players in the intricate dance of embryonic development,tissue maintenance,and regenera-tion.Their behavior is delicately balanced between maintaining their pluripotency and differentiating as n...
关键词：Stem cell fate SELF-RENEWAL QUIESCENCE Differentiation FOXO 
Commentary on“Desialylated Platelets Maintain Immune Quiescence through Regulating Kupffer Cells”
《Research》2024年第3期621-623,共3页Chen Li Craig N.Morrell 
Platelets have long been studied for their roles in hemostasis and vascular injury repair. However, there is a continually evolving and deepening understanding that platelets initiate and regulate responses to tissue ...
关键词：PLATELET homeostasis IMMUNE 
Ptip safeguards the epigenetic control of skeletal stem cell quiescence and potency in skeletogenesis被引量：1
《Science Bulletin》2024年第13期2099-2113,共15页Jianfei Liang Jing Wang Bingdong Sui Yibo Tong Jihua Chai Qin Zhou Chenxi Zheng Hao Wang Liang Kong Haojian Zhang Yi Bai 
supported by the National Key Research and Development Program of China(2022YFA0103200);the National Natural Science Foundation of China(82325003,82230007,82200188,82270956 and 82171568);the National Defense Biotechnology Outstanding Young Talents Fund(01-SWKJYCJJ24);Shaanxi Province Innovation Capability Support Program Scientific and Technological Innovation Team(2023-CX-TD-69).
Stem cells remain in a quiescent state for long-term maintenance and preservation of potency;this process requires fine-tuning regulatory mechanisms.In this study,we identified the epigenetic landscape along the devel...
关键词：Skeletal stem cells Bone development Epigenetics Ptip GLYCOLYSIS 
Plant cuticles repress organ initiation and development during skotomorphogenesis in Arabidopsis
《Plant Communications》2024年第6期100-116,共17页Yuru Ma Wenwen Chang Yongpeng Li Jiahui Xu Yongli Song Xinmiao Yao Lei Wang Yu Sun Lin Guo Hao Zhang Xigang Liu 
supported by the National Natural Science Foundation of China(32270340 and 31970824 to X.L.and 32300304 to H.Z.);the project“Fulltime introduction of high-end talent research project”(2020HBQZYC004 and A202105008 to X.L.)from Hebei province;funding from the Hebei Natural Science Foundation(C2021205013 to X.L.,C2021205043 to L.G.,and C2023205049 to Y.Sun).
After germination in the dark,plants produce a shoot apical hook and closed cotyledons to protect the quiescent shoot apical meristem(SAM),which is critical for seedling survival during skotomorphogenesis.The factors ...
关键词：plant cuticles SAM quiescence organ initiation skotomorphogenesis PHOTOMORPHOGENESIS 
Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis被引量：2
《Cellular & Molecular Immunology》2024年第6期546-560,共15页Zhiqiang Xiao Shanshan Wang Liang Luo Wenkai Lv Peiran Feng Yadong Sun Quanli Yang Jun He Guangchao Cao Zhinan Yin Meixiang Yang 
Natural Science Foundation of China(to M.Y.,82271754 and 82071737,to Z.Y.,32030036,to Q.Y.,32000615,and to P.F.,82301974);China Postdoctoral Science Foundation(to P.F.,2023M741377);Guangdong Basic and Applied Basic Research Fund(to Q.Y.,2023A1515012582,to P.F.,2022A1515110217,and to G.C.,2023B1515020018);111 Project(to Z.Y.,B16021).
γδT cells play a crucial role in immune surveillance and serve as a bridge between innate and adaptive immunity.However,the metabolic requirements and regulation ofγδT-cell development and function remain poorly u...
关键词：LKB1 γδT cell Autoimmune hepatitis IL-17 Metabolic quiescence 
Epigenetic memory of drug exposure history controls neural stem cell quiescence in the adult brain
《Neural Regeneration Research》2024年第4期711-712,共2页Masakazu Iwamoto Taito Matsuda 
supported by a Grant-in-Aid for Scientific Research(B)JP21H02808(to TM);JST SPRING JPMJSP2136(to MI)。
Neural stem cells(NSCs)are the source of all neurons and glial cells(astrocytes and oligodendrocytes)in the central nervous system.The adult mammalian brain retains NSCs in the subgranular zone of the dentate gyrus in...
关键词：NEURAL INTEGRATE continuously 
Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance被引量：2
《Genes & Diseases》2024年第1期189-204,共16页Ebrahim H.Maleki Ahmad Reza Bahrami Maryam M.Matin 
Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology,as it represents a major obstacle to effective cancer treatment.Since tumor cells are highly diverse at genetic,epigenetic,and ...
关键词：Cancer stem cells(CSCs) CARCINOMA Cell cycle heterogeneity QUIESCENCE Therapy resistance Therapy tolerance Tumor dormancy 
Dynamics of a Reaction-Diffusion System with Quiescence
《Journal of Contemporary Educational Research》2023年第10期140-144,共5页Huichao Xu 
In this paper,the dynamical behavior of a reaction-diffusion system with quiescence in a closed environment is investigated.The global existence of the solution is obtained by the upper and lower solution method,and t...
关键词：REACTION-DIFFUSION DISSIPATIVE QUIESCENCE 
Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling被引量：3
《Signal Transduction and Targeted Therapy》2023年第7期3524-3535,共12页Cong Li Shi Qiu Xiaohan Liu Fengzhu Guo Jingtong Zhai Zhijun Li Linghui Deng Liming Ge Haili Qian Lu Yang Binghe Xu 
This work was supported by following fundings:CAMS Innovation Fund for Medical Sciences(CIFMS)2021-I2M-1-014;the National Natural Science Foundation of China(Grant No.81902578,81974098,8197032158);the National key research and development program of China(Grant No.2017YFC0908003,2017YFC0908004);the Project of Health Commission of Sichuan Province(20PJ062);Post-doctoral Science Research Foundation of Sichuan University(2020SCU12041);Post-Doctor Research Project,West China Hospital,Sichuan University(2018HXBH084).
The extracellular matrix(ECM)serves as signals that regulate specific cell states in tumor tissues.Increasing evidence suggests that extracellular biomechanical force signals are critical in tumor progression.In this ...
关键词：BREAST cancer matrix 
Vitamin D receptor (VDR) mediates the quiescence of activated hepatic stellate cells (aHSCs) by regulating M2 macrophage exosomal smooth muscle cell-associated protein 5 (SMAP-5)
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第3期248-261,共14页Xuwentai LIU Yue WU Yanyi LI Kaiming LI Siyuan HOU Ming DING Jingmin TAN Zijing ZHU Yingqi TANG Yuming LIU Qianhui SUN Cong WANG Can ZHANG 
supported by the National Natural Science Foundation of China(Nos.81930099,81773664,82130102,92159304,81703585,and 81903651);the Natural Science Foundation of Jiangsu Province(Nos.BK20212011 and BK20180565);the Technology Innovation Project of Nucleic Acid Drug from National Center of Technology Innovation for Biopharmaceuticals(No.NCTIB2022HS01014);the“Double First-Class”University Project(No.CPU2022QZ05);the 111 Project from the Ministry of Education of China and the State Administration of Foreign Expert Affairs of China(Nos.111-2-07 and B17047);the Fundamental Research Funds for the Central Universities of China(No.2632022ZD11);the Open Project of State Key Laboratory of Natural Medicines(No.SKLNMZZ202017),China.
An effective therapeutic regimen for hepatic fibrosis requires a deep understanding of the pathogenesis mechanism.Hepatic fibrosis is characterized by activated hepatic stellate cells(aHSCs)with an excessive productio...
关键词：Hepatic fibrosis Hepatic stellate cell(HSC) MACROPHAGE EXOSOME Vitamin D receptor(VDR) Smooth muscle cell-associated protein 5(SMAP-5) 
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