Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling  

作　　者：Cong Li Shi Qiu Xiaohan Liu Fengzhu Guo Jingtong Zhai Zhijun Li Linghui Deng Liming Ge Haili Qian Lu Yang Binghe Xu 

机构地区：[1]Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China [2]State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China [3]Department of Urology,Institute of Urology and National Clinical Research Center for Geriatrics,West China Hospital of Sichuan University,Chengdu 610041,China [4]National Clinical Research Center of Geriatrics,The Center of Gerontology and Geriatrics,West China Hospital,Sichuan University,Chengdu 610065,China [5]Institute of Oncology Research(IOR),Oncology Institute of Southern Switzerland(IOSI),Bellinzona 6500,Switzerland [6]Department of Histology and Embryology,Basic Medical College,China Medical University,Shenyang,Liaoning 110122,China [7]Department of Pharmaceutical and Bioengineering,School of Chemical Engineering,Sichuan University,Chengdu 610065,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第7期3524-3535,共12页信号转导与靶向治疗（英文）

基　　金：This work was supported by following fundings:CAMS Innovation Fund for Medical Sciences(CIFMS)2021-I2M-1-014;the National Natural Science Foundation of China(Grant No.81902578,81974098,8197032158);the National key research and development program of China(Grant No.2017YFC0908003,2017YFC0908004);the Project of Health Commission of Sichuan Province(20PJ062);Post-doctoral Science Research Foundation of Sichuan University(2020SCU12041);Post-Doctor Research Project,West China Hospital,Sichuan University(2018HXBH084).

摘　　要：The extracellular matrix(ECM)serves as signals that regulate specific cell states in tumor tissues.Increasing evidence suggests that extracellular biomechanical force signals are critical in tumor progression.In this study,we aimed to explore the influence of ECM-derived biomechanical force on breast cancer cell status.Experiments were conducted using 3D collagen,fibrinogen.

关 键 词：BREAST cancer matrix 

分 类 号：R737.9[医药卫生—肿瘤]