The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases  

作　　者：Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia 

机构地区：[1]Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences,Harbin Medical University,Harbin,Heilongjiang Province,China [2]College of Basic Medical Sciences,Harbin Medical University,Harbin,Heilongjiang Province,China [3]Basic Medical Institute,Heilongjiang Academy of Medical Sciences,Harbin,Heilongjiang Province,China [4]Key Laboratory of Heilongjiang Province for Genetically Modified Animals,Harbin Medical University,Harbin,Heilongjiang Province,China [5]Translational Medicine Research and Cooperation Center of Northern China,Heilongjiang Academy of Medical Sciences,Harbin,Heilongjiang Province,China [6]Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,China

出　　处：《Neural Regeneration Research》2025年第6期1582-1598,共17页中国神经再生研究（英文版）

基　　金：supported by the Natural Science Foundation of Heilongjiang Province of China,Outstanding Youth Foundation,No.YQ2022H003 (to DW)。

摘　　要：N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be attributed to the timespecific nature of m^(6)A a

关 键 词：Alzheimer's disease cell self-renewal central nervous system MEMORY MICROGLIA nerve regeneration neurodegenerative diseases NEUROGENESIS RNA methylation 

分 类 号：R741[医药卫生—神经病学与精神病学]