BIOINFORMATICS

作品数：699被引量：2737H指数：15
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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke
《Neural Regeneration Research》2025年第7期2015-2028,共14页Jian Yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li 
supported by the National Natural Science Foundation of China,Nos.82071307(to HL),82271362(to HL),82171294(to JW),82371303(to JW),and 82301460(to PX);the Natural Science Foundation of Jiangsu Province,No.BK20211552(to HL);Suzhou Medical Technology Innovation Project-Clinical Frontier,No.SKY2022002(to ZY);the Science and Education Foundation for Health of Suzhou for Youth,No.KJXW2023001(to XL)。
Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination.Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe n...
关键词：BIOINFORMATICS bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing 
Using bioinformatics methods to elucidate fatty acid-binding protein 4 as a potential biomarker for colon adenocarcinoma
《World Journal of Gastrointestinal Oncology》2025年第4期161-177,共17页Yun Zhang Wen-Li Zhu Min Wu Tian-Yuan Gao Hui-Xian Hu Zheng-Yuan Xu 
Supported by the University Scientific Research Project of Anhui Province,No.2024AH051916;the Quality Engineering Project of Anhui Province,No.2022sx159 and No.2022sdxx031;the Key Research and Development Project of Anhui Province,No.2022e07020036.
BACKGROUND Colon adenocarcinoma(COAD)ranks second in terms of cancer-related deaths.We found that fatty acid-binding protein 4(FABP4),which is related to cell adhesion and immunity,affects the occurrence and developme...
关键词：FABP4 Colon adenocarcinoma BIOMARKER Cell adhesion Immune pathways Prognostic nomogram 
Snail family transcriptional repressor 1 radiosensitizes esophageal cancer via epithelial-mesenchymal transition signaling: From bioinformatics to integrated study
《World Journal of Gastrointestinal Oncology》2025年第4期286-299,共14页Xiao-Li Lv Qi-Liang Peng Xin-Peng Wang Zhi-Chao Fu Jian-Ping Cao Jian Wang Li-Li Wang Yang Jiao 
Supported by the National Key R&D Program of China,No.2022YFC2503700 and No.2022YFC2503703;the National Health Commission Key Laboratory of Nuclear Technology Medical Transformation(Mianyang Central Hospital),No.2023HYX005.
BACKGROUND Esophageal cancer(ESCA)poses a significant challenge in oncology because of the limited treatment options and poor prognosis.Therefore,enhancing the therapeutic effects of radiotherapy for ESCA and identify...
关键词：Esophageal cancer RADIOSENSITIVITY Snail family transcriptional repressor 1 BIOINFORMATICS Epithelial-mesenchymal transition 
Identification of PBL Gene Family in Tree Peonies and Its Function in Regulating Pollen Tube Growth
《Phyton-International Journal of Experimental Botany》2025年第4期1159-1176,共18页Yuxin Zhao Zhanxiang Tan Yuying Li Kaiyue Zhang Lili Guo Xiaogai Hou 
supported by the National Natural Science Foundation of China[Grant Number U23A20211].
Receptor-like cytoplasmic kinases(RLCKs)play a crucial role in the physiological processes of plant growth and development and stress response.To elucidate the characteristics and functions of the PBL gene family in t...
关键词：Tree peony PBL gene family bioinformatics analytics expression analysis 
Bioinformatics-based analysis of autophagy-related genes and prediction of potential Chinese medicines in diabetic kidney disease
《Digital Chinese Medicine》2025年第1期90-99,共10页Yufeng XING Zining PENG Chaoyang YE 
National Natural Science Foundation of China(82170747),and Shanghai Key Laboratory of Traditional Chinese Clinical Medicine(20DZ2272200).
Objective To predict the autophagy-related pathogenesis and key diagnostic genes of diabetic kidney disease(DKD)through bioinformatics analysis,and to identify related Chinese medicines.Methods Data from sequencing mi...
关键词：BIOINFORMATICS Differentially expressed genes Diabetic kidney disease Autophagy genes Prediction of Chinese medicines 
Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism
《World Journal of Gastrointestinal Oncology》2025年第3期202-220,共19页Ling Wu Hong-Yao Chen Jing-Ting Zhang Ren-Yi Yang Zhi-Bin Wang Pei-Sen Xue Wei Peng Ke-Xiong Li Wen-Hui Gao Pu-Hua Zeng 
the National Natural Science Foundation of China,No.82074425;Natural Foundation of Hunan Province,No.2023JJ30364 and No.2023JJ30361;Hunan Provincial Key R&D Program,No.2023SK2057;Key Project of Hunan Provincial Administration of Traditional Chinese Medicine,No.A2023042.
BACKGROUND Ferroptosis is an iron-dependent programmed non-apoptotic cell death characterized by the accumulation of free iron ions and lipid peroxidation.It is associated with the inactivation of glutathione peroxida...
关键词：Chlorogenic acid Hepatocellular carcinoma Ferroptosis Prostaglandin endoperoxide synthase 2/aldo-keto reductase family 1 member C3/glutathione peroxidase 4 axis BIOINFORMATICS In vitro experiment 
Transmembrane channel-like 5 drives hepatocellular carcinoma progression by regulating epithelial-mesenchymal transition
《World Journal of Clinical Oncology》2025年第3期68-82,共15页Jiao Li Zi-Yu Wang Yan Jin Jing Xu Yun-Jin Ya Ting-Qiu Wan Xi Li Xi Wang 
Supported by the Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Special Project on Applied Basic Research,No.202401AY070001-132;the Yunnan Provincial Science Foundation,No.2018FE001(-287);National Natural Science Foundation of China,No.81460443;the Ten Thousand People Plan of Yunnan Province,No.KH-SWR-MY-2020-002.
BACKGROUND Hepatocellular carcinoma(HCC)is a difficult cancer to manage due to its highly invasive and metastatic nature.AIM To investigate the molecular function of transmembrane channel-like 5(TMC5)in vitro and in v...
关键词：Hepatocellular carcinoma Transmembrane channel-like protein 5 Epithelial-mesenchymal transition BIOINFORMATICS diagnosis Prognosis 
Profiling and bioinformatics analyses of circular RNAs in myocardial ischemia/reperfusion injury model in mice
《World Journal of Cardiology》2025年第1期65-77,共13页Jiao-Ni Wang Ying-Ying Zhou Yong-Wei Yu Jun Chen 
Supported by Zhejiang Provincial Natural Science Foundation of China,No.LQ23H020004;The Medical and Health Research Project of Zhejiang province,No.2024KY983;Basic Medical Health Technology Project of Wenzhou Science and Technology Bureau,No.Y20210818 and No.Y20210140.
BACKGROUND Myocardial ischemia/reperfusion(I/R)injury,which is associated with high morbidity and mortality,is a main cause of unexpected myocardial injury after acute myocardial infarction.However,the underlying mech...
关键词：Rna-sequencing Circular RNA MicroRNA CeRNA Myocardial ischemia/reperfusion Bioinformatics analyses 
Data-Driven Healthcare:The Role of Computational Methods in Medical Innovation
《Computer Modeling in Engineering & Sciences》2025年第1期1-48,共48页Hariharasakthisudhan Ponnarengan Sivakumar Rajendran Vikas Khalkar Gunapriya Devarajan Logesh Kamaraj 
The purpose of this review is to explore the intersection of computational engineering and biomedical science,highlighting the transformative potential this convergence holds for innovation in healthcare and medical r...
关键词：Computational models biomedical engineering BIOINFORMATICS machine learning wearable technology 
Bioinformatics analysis of the association between miR-942-5p–induced downregulation of PIEZO-type mechanosensitive ion channel component 1 and poor prognosis in non–small cell lung cancer mediated by the mitogen-activated protein kinase pathway signaling pathway
《Oncology and Translational Medicine》2024年第6期272-280,共9页Lingdi Duan Min Zhao Hongquan Wei Wei Dong Xiaomin Bi Lin Ang Shan Zhang 
supported by grants from the Hefei Municipal Health Commission Applied Medical Research Project(no.Hwk2021yb012);Hefei Municipal Health Commission Applied Medical Research Project(no.Hwk2023zd007).
Background:Non–small cell lung cancer(NSCLC)is a common malignant tumor with an increasing incidence.PIEZO-type mechanosensitive ion channel component 1(PIEZO1)is a mechanosensitive ion channel whose expression has b...
关键词：Non–small cell lung cancer PIEZO1 BIOINFORMATICS MAPK MiR-942-5p 
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