cGAS-STING signaling pathway in lung cancer:Regulation on antitumor immunity and application in immunotherapy  

作　　者：Jing Wu Yingyao Chen Mengqing Xie Xin Yu Chunxia Su 

机构地区：[1]Department of Oncology,Shanghai Pulmonary Hospital&Thoracic Cancer Institute,Tongji University School of Medicine,Shanghai 200433,China

出　　处：《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第4期257-264,共8页呼吸与危重症医学(英文)

基　　金：supported by the National Natural Science Foundation of China(Nos.82373320,82072568);the Shanghai Shenkang Hospital Development Center(No.SHDC12020110);the Shanghai Pulmonary Hospital Fund(No.fkzr2403);the National Key Research and Development Program of China(No.2023YFC2508603)。

摘　　要：The innate immune system has a primary role in defending against external threats,encompassing viruses,bac-teria,and fungi,thereby playing a pivotal role in establishing robust protection.Recent investigations have shed light on its importance in the progression of tumors,with a particular emphasis on lung cancer.Among the various signaling pathways implicated in this intricate process,the cGAS-STING pathway emerges as a signifi-cant participant.Cyclic GMP-AMP synthase(cGAS)discerns free DNA and activates the stimulator of interferon genes(STING),subsequently culminating in the secretion of cytokines and exerting inhibitory effects on tumor development.Consequently,researchers are increasingly interested in creating anticancer drugs that specifically target the cGAS-STING pathway,offering promising avenues for novel therapeutic interventions.The objective of this review is to present a comprehensive overview of the ongoing research on the cGAS-STING signaling path-way within the realm of lung cancer.The primary emphasis is on understanding its involvement in lung cancer development and assessing its viability as a target for innovative therapeutic options.

关 键 词：Cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING) Lung cancer Tumor microenvironment 

分 类 号：R73[医药卫生—肿瘤]