Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration  

作　　者：Bryan Sun Lulin Li Jian Luo 

机构地区：[1]Palo Alto Veterans Institute for Research,VA Palo Alto Health Care System,Palo Alto,CA,USA [2]Polytrauma System of Care,VA Palo Alto Health Care System,Palo Alto,CA,USA

出　　处：《Neural Regeneration Research》2025年第7期2005-2007,共3页中国神经再生研究（英文版）

基　　金：partially supported by a grant(RF1AG059694)from the U.S.National Institutes of Health;by Polytrauma System of Care,VAPAHCS(to JL)。

摘　　要：The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of neuroinflammation.While current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial cells.Therefore,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic interventions.Here,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关 键 词：STIMULATOR INTERFERON inflammation 

分 类 号：R741[医药卫生—神经病学与精神病学]