Plasma extracellular cold inducible RNA-binding protein levels are elevated for 1 month post-colectomy which may promote metastases  

作　　者：H M C Shantha Kumara Poppy Addison Xiao-Hong Yan Anuj Raj Sharma Neil Mitra Hansani N Angammana Yanni Hedjar Yi-Ru Chen Vesna Cekic Whelan L Richard 

机构地区：[1]Division of Colon and Rectal Surgery,Department of Surgery,Lenox Hill Hospital,Northwell Health,New York,NY 10028,United States [2]Northwell,New Hyde Park,New York,NY 10042,United States [3]Division of Colon and Rectal Surgery,Department of Surgery,Staten Island University Hospital,Northwell Health,Staten Island,NY 10305,United States [4]Department of Pathology and Cell Biology,Columbia University Medical Center,Vanderbilt Clinic,New York,NY 10032,United States [5]Department of Surgery,Brookdale Hospital and Medical Center,Brooklyn,NY 11212,United States [6]Donald and Barbara Zucker School of Medicine,Hofstra/Northwell 500 Hofstra Blvd,Hempstead,NY 11549,United States

出　　处：《World Journal of Gastrointestinal Oncology》2025年第4期318-326,共9页世界胃肠肿瘤学杂志(英文)

摘　　要：BACKGROUND Cold-inducible RNA-binding protein(CIRP)is related to a family of stressinduced RNA-binding proteins.It is primarily found in the nucleus,where it regulates transcription.Under stress,CIRP translocates to the cytoplasm where it modulates translation;a subset is secreted as extracellular CIRP(eCIRP)which is a damage-associated molecular pattern(DAMP)molecule that stimulates the production of inflammatory mediators.Elevated blood eCIRP levels may foster immune tolerance and facilitate tumor growth.Increased CIRP levels have been noted in various malignancies including colorectal cancer(CRC).This study’s objective was to determine plasma eCIRP levels before and after minimally invasive colorectal resection(MICR)for CRC.AIM To assess plasma eCIRP levels prior to and following minimally invasive colorectal resection in the context of cancer pathology.METHODS MICR patients from an IRB-approved data/tissue bank for whom plasma samples were available were eligible.Plasma specimens were obtained preoperatively(preop)and at least 3 time’s postop[between postoperative day(POD)1-41];late samples were grouped into 7-day blocks and were considered separate time points.eCIRP levels were assessed via enzyme-linked immunosorbent assay(pg/mL)and results presented as mean±SD,analysis with Wilcoxon paired t-test.RESULTS A total of 83 CRC patients who underwent MICR[colon 66%,rectal 34%;laparoscopic-assisted(LA),70%;handassisted laparoscopic(HAL),30%]were studied.The mean preop eCIRP level was 896.8±757.0 pg/mL.Elevations in mean plasma levels(P=<0.001)were noted on POD1(2549±2632 pg/mL,n=83),POD3(1871±1362 pg/mL,n=77),POD7-13(1788±1403 pg/mL,n=57),POD14-20(1473±738.8 pg/mL,n=30),and POD21-27(1681±1375 pg/mL,n=21).No significant differences were noted at POD 28-41.Higher values were noted in the HAL’s(vs LA)group,however,there were more rectal cancers in the former.CONCLUSION Elevated plasma eCIRP levels persist for a month post MICR for CRC(change from baseline,77%-184%);highest values seen on POD1.The initia

关 键 词：Effects of surgery Plasma extracellular cold-inducible RNA-binding protein levels Colorectal resection Colorectal cancer Angiogenesis 

分 类 号：R73[医药卫生—肿瘤]