MICROTUBULE

作品数：203被引量：330H指数：8
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相关作者：卢永根刘向东李洁龄董伟光李峻柏更多>>
相关机构：中国科学院华南农业大学哈尔滨医科大学北京大学更多>>
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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo
《Neural Regeneration Research》2025年第9期2633-2644,共12页Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He 
supported by the National Natural Science Foundation of China,No.82201582(to QT);Scientific and Technological Research Program of Chongqing Municipal Education Commission,No.KJQN202200457(to QT);General Project of Changqing Natural Science Foundation,No.cstc2021jcyjmsxmX0442(to ZL);CQMU Program for Youth Innovation in Future Medicine,No.W0044(to ZD and GH);Direct Research Project for PhD of Chongqing,No.CSTB2022BSXM-JCX0051(to ZL);the Project of the Top-Notch Talent Cultivation Program For the Graduate Students of Chongqing Medical University,No.BJRC202310(to CG)。
Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque formation.Therefore,resto ring normal lysosomal funct...
关键词：Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPASE 
CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system
《Neural Regeneration Research》2025年第8期2420-2432,共13页Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li 
supported by the National Nature Science Foundation of China,No.32101020(to JL);the Natural Science Foundation of Shandong Province,Nos.ZR2020MC071(to JL),ZR2023MH327(to HZ);the Integrated Project of Major Research Plan of National Natural Science Foundation of China,No.92249303(to PL);the Natural Science Foundation of Qingdao,No.23-2-1-193-zyyd-jch(to HZ)。
The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding domains.Variants of the CNKS...
关键词：autism spectrum disorder CENTROSOME CNKSR2 intellectual disability INTERACTOME mass spectrometry MICROTUBULE neurodevelopmental disease protein complexes protein-protein interactions 
Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets
《Asian Journal of Andrology》2025年第2期245-253,共9页Tao Liu Fazal Rahim Meng-Lei Yang Meftah Uddin Jing-Wei Ye Imtiaz Ali Yousaf Raza Abu Mansoor Muhammad Shoaib Mujahid Hussain Ihsan Khan Basit Shah Asad Khan Ahmad Nisar Hui Ma Bo Xu Wasim Shah Qing-Hua Shi 
s supported by the National Natural Science Foundation of China(No.82171599 and No.32270901);the National Key Research and Developmental Program of China(2022YFC2702601 and 2022YFA0806303);the Global Select Project(DJKLX-2022010)of the Institute of Health and Medicine,Hefei Comprehensive National Science Center.
Male infertility can result from impaired sperm motility caused by multiple morphological abnormalities of the flagella(MMAF).Distinct projections encircling the central microtubules of the spermatozoal axoneme play p...
关键词：C1a projection central apparatus male infertility multiple morphological abnormalities of the flagella SPAG17 
The plant retromer components SNXs bind to ATG8 and CLASP to mediate autophagosome movement along microtubules
《Molecular Plant》2025年第3期416-436,共21页Yanglan Liao Xibao Li Wenlong Ma Xinyi Lin Jiayi Kuang Xuanang Zheng Zien Li Fanfan Qiao Chuanliang Liu Jun Zhou Faqiang Li Ruixi Li Byung-Ho Kang Hongbo Li Caiji Gao 
supported by grants from the National Natural Science Foundation of China(32270291,32061160467,32470797,and 31870171);the Guangdong Province Rural Revitalization Strategy Special Funding for Seed Industry Vitalization to C.G.,the NSFC grant(32000365,32370329);Guangdong Basic and Applied Basic Research Foundation(2021A1515010913,2024B1515020043);H.L.,and the Research Grant Council of Hong Kong(GRF14113921,GRF14109222,GRF14110823,N_CUHK462/22,and C4014-23G)to B.-H.K.
In eukaryotic cells,autophagosomes are double-membrane vesicles that are highly mobile and traffic along cytoskeletal tracks.While core autophagy-related proteins(ATGs)and other regulators involved in autophagosome bi...
关键词：autophagy SNX CLASP MICROTUBULE autophagosome trafficking Arabidopsis thaliana 
FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation
《Science China(Life Sciences)》2025年第3期673-688,共16页Dake Xiao Haowen Ran Lishu Chen Yuanyuan Li Yan Cai Songyang Zhang Qinghui Qi Huiran Wu Cheng Zhang Shuailiang Cao Lanjuan Mi Haohao Huang Ji Qi Qiuying Han Haiqing Tu Huiyan Li Tao Zhou Fangye Li Ailing Li Jianghong Man 
supported by the National Key Research and Development Program of China(2022YFA1303000,2017YFA0505602);the National Natural Science Foundation of China(81872408,81872153).
The infiltration of glioblastoma multiforme(GBM)is predominantly characterized by diffuse spread,contributing significantly to therapy resistance and recurrence of GBM.In this study,we reveal that microtubule deacetyl...
关键词：glioblastoma multiforme(GBM) microtubule deacetylation invasion FSD1 HDAC6 
Combined BRAF G469A mutation and echinoderm microtubule associated protein like-4-anaplastic lymphoma kinase rearrangement with resistance:A case report and review of literature
《World Journal of Clinical Oncology》2025年第2期165-172,共8页Xuan Guo Yan Liu Yu-Ting Wang Kan Liu Hui Ding 
Supported by the Medical Education Collaborative Innovation Fund of Jiangsu University,No.JDY2022015。
BACKGROUND Through deeper understanding of targetable driver mutations in non-small-cell lung cancer(NSCLC)over the past years,some patients with driver mutations have benefited from the targeted molecular therapies.A...
关键词：Non-small-cell lung cancer Driver mutation REARRANGEMENT RESISTANCE Case report 
The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons
《Neural Regeneration Research》2025年第1期209-223,共15页Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang 
supported by the National Key Research and Development Program of China,No.2021ZD0202503(to AHT);the National Natural Science Foundation of China,Nos.31872759(to AHT)and 32070707(to CF);Shenzhen Science and Technology Program,No.RCJC20210609104333007(to ZW);Shenzhen-Hong Kong Institute of Brain Science,Shenzhen Fundamental Research Institutions,No.2021SHIBS0002(to ZW).
Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and memory.Kinesin-4 KIF21A helps organize the microtubule-actin network at th...
关键词：ACTIN CYTOSKELETON dendrite KANK1 KIF21A MICROTUBULE spine morphology SPINE synaptic plasticity talin1 
Fish scale-inspired biomimetic nanocoatings on magnesium implants for vascularized bone regeneration in infected bone defects
《Journal of Magnesium and Alloys》2025年第1期311-329,共19页Dan Li Danni Dai Jianrong Wang Zhen Ai Chao Zhang 
supported by the National Natural Science Foundation of China[81801007];the Traditional Chinese Medicine Bureau of Guangdong Province[20242062];the Major of Basic and Applied Basic Research Project of Guangzhou City[202201011601];the Science and Cultivation Foundation of Stomatological Hospital of Southern Medical University[PY2021016];the Guangdong Province Clinical Teaching Base Teaching Reform Research Project[2023JD054].
The regeneration of infected bone defects is still challenging and time-consuming,due to the adverse osteogenic microenvironment caused by bacterial contamination and pronounced ischemia.Biodegradable magnesium(Mg)-ba...
关键词：Infected bone defects Biodegradable magnesium alloy Biomimetic nanocoating Microtubule stability Vascularized bone regeneration 
Inducible Fgf13 ablation alleviates cardiac fibrosis via regulation of microtubule stability
《Acta Biochimica et Biophysica Sinica》2024年第12期1802-1812,共11页Cong Wang Xiangchong Wang Yiyi Zhang Yuan Mi Yanxue Han Yaxin Zhi Ran Zhao Nanqi Cui Qianli Ma Huaxing Zhang Dazhong Xue Ruoyang Qiao Jiabing Han Yulou Yu Jiaxuan Li Mohammed Shaiea Demin Liu Guoqiang Gu Chuan Wang 
supported by the grants from the National Natural Science Foundation of China(Nos.81770407 and 31171097);the Key Project of Precision Medicine Joint Fund of Natural Science Foundation of Hebei Province(No.H2020206409);the College Students Innovative Pilot Project in Hebei Medical University(No.USIP2023011);the Science Fund for Creative Research Groups of Natural Science Foundation of Hebei Province(No.H2020206474).
Fibroblast growth factor(FGF)isoform 13,a distinct type of FGF,boasts significant potential for therapeutic intervention in cardiovascular dysfunctions.However,its impact on regulating fibrosis remains unexplored.This...
关键词：FGF13 cardiac fibrosis FIBROBLASTS MICROTUBULE ROCK 
Microtubule polymerization induced by iridium-fullerene photosensitizers for cancer immunotherapy via dual-reactive oxygen species regulation strategy
《Aggregate》2024年第6期272-283,共12页Xiao-Xiao Chen Kun Peng Xi Chen Zheng-Yin Pan Qing-Hua Shen Yu-Yi Ling Jian-Zhang Zhao Cai-Ping Tan 
National Natural Science Foundation of China,Grant/Award Number:22177142;Basic and Applied Basic Research Foundation of Guangdong Province,Grant/Award Numbers:2022A1515111089,2023A1515010625,2024B1515040028。
Microtubules(MTs)are key players in cell division,migration,and signaling,and they are regarded as important targets for cancer treatment.In this work,two fullerene(C_(60))-functionalized Ir(Ⅲ)complexes(Ir-C_(60)1 an...
关键词：ANTICANCER FULLERENE iridium complexes MICROTUBULE photo-immunotherapy 
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