Viral epidemics pose major threats to global health and economies.A hallmark of viral infection is the reshaping of host cell membranes and cytoskeletons to form organelle-like structures,known as viral factories,whic...
Vascular smooth muscle cells (VSMCs) in the arterial walls play important roles in regulating vascular contraction and dilation. VSMCs actively remodel the arterial walls and dedifferentiate from the contractile to th...
supported by the National Key Research and Development Program of China,No.2021ZD0202503(to AHT);the National Natural Science Foundation of China,Nos.31872759(to AHT)and 32070707(to CF);Shenzhen Science and Technology Program,No.RCJC20210609104333007(to ZW);Shenzhen-Hong Kong Institute of Brain Science,Shenzhen Fundamental Research Institutions,No.2021SHIBS0002(to ZW).
Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and memory.Kinesin-4 KIF21A helps organize the microtubule-actin network at th...
supported by the National Science Fund for Distinguished Young Scholars of China (No.81925015);the National Natural Science Foundation of China (No.91649202);the Shandong Provincial Key Research&Development Program (China) (No.2018YFJH0504);the open fund of the State Key Laboratory of Reproductive Medicine (China) (SKLRM-K202201).
Infertility affects around 8%-12%of couples globally,and in about 50%of these cases,male factors are either the primary cause or contribute significantly to infertility.Any defects during spermiogenesis may result in ...
supported by the National Science Fund for Distinguished Young Scholars(81925015);the Youth Innovation Promotion Association of CAS(2018109).
Spermiation is the process that releases mature spermatids from Sertoli cells into the lumen of the seminiferous tubule.Tubulobulbar complexes(TBCs)are elaborate cytoskeleton-related structures that are indispensable ...
National Natural Science Foundation of China for Z.K.(grant nos.31925003,32230007,32241045)and X.Z.(grant no.32000142).
The legume-rhizobium symbiosis represents the most important system for terrestrial biological nitrogen fixation on land.Efficient nitrogen fixation during this symbiosis depends on successful rhizobial infection and ...
supported by the National Natural Science Foundation of China(82130011,92249301).
The endothelium,lining the inner surface of blood vessels and spanning approximately 3 m^(2),serves as the largest organ in the body.Comprised of endothelial cells,the endothelium interacts with other bodily component...
the National Natural Science Foundation of China(No.82103419,and 82230050);the Research and Development Fund of Peking University People’s Hospital,Beijing,China(No.RS2021-05,and RDY2021-13).
Endometrial cancer(EC)is one of the most prominent malignancies in gynecology.Unfortunately,despite these advancements in understanding EC pathogenesis,mortality rates have not decreased.Traction force(TF)refers to en...
funded by the National Key Research and Development Program of China (2022YFF1001500);the National Natural Science Foundation of China (grant numbers 31970284,31900385);the Natural Science Foundation of Fujian Province,China (2023J01483, 2022J01616);the Distinguished Young Scientists Fund of Fujian Agriculture and Forestry University of China (xjq202121);the Fujian Provincial Science and Technology Key Project (2022NZ030014)
Magnaporthe oryzae(M.oryzae)is a devastating hemibiotrophic pathogen.Its biotrophic invasive hyphae(IH)are enclosed in the extrainvasive hyphal membrane produced by plant cells,thus generating a front line of the batt...
Supported by the Natural Science Foundation of China(No.81473369);the National Key Research and Development Program of China(No.2017YFC1702703);Jinan City Science and Technology SMES Innovation Ability Improvement Project,“Traditional Chinese Medicine Digital Humanities Youth Innovation Team”of College and University in Shandong Province(No.2023RW093)。
Objective:To explore the potential mechanism of lysionotin in treating glioma.Methods:First,target prediction based on Bernoulli Naïve Bayes profiling and pathway enrichment was used to predict the biological activity...