Traction force with extracellular matrix mediated by cytoskeleton influences metastasis through SLC8A1 induced Wnt-b-catenin pathway in endometrial cancer  

作　　者：Xingchen Li Xin Xu Jianliu Wang 

机构地区：[1]Department of Obstetrics and Gynecology,Peking University People’s Hospital,Beijing 100044,China [2]Department of Obstetrics and Gynecology,Beijing ChaoYang Hospital,Capital Medical University,Beijing 100020,China

出　　处：《Genes & Diseases》2024年第5期98-101,共4页基因与疾病（英文）

基　　金：the National Natural Science Foundation of China(No.82103419,and 82230050);the Research and Development Fund of Peking University People’s Hospital,Beijing,China(No.RS2021-05,and RDY2021-13).

摘　　要：Endometrial cancer(EC)is one of the most prominent malignancies in gynecology.Unfortunately,despite these advancements in understanding EC pathogenesis,mortality rates have not decreased.Traction force(TF)refers to endogenous mechanical forces exerted by cells.1 These forces act on the extracellular matrix and the extracellular tumor microenvironment through focal adhesions,thereby regulating cell proliferation and migration.However,the TF characteristics of endometrial cancer cells and their heterogeneity remain unclear.

关 键 词：ENDOMETRIAL METASTASIS ENDOGENOUS 

分 类 号：R73-37[医药卫生—肿瘤]