ACTIN

作品数:324被引量:829H指数:13
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相关领域:医药卫生更多>>
相关作者:伍国强李莹辉郭志雄王学敏潘东明更多>>
相关机构:兰州大学中国农业大学中国科学院上海生命科学研究院福建农林大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划广东省自然科学基金更多>>
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Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology
《Neural Regeneration Research》2025年第9期2589-2590,共2页Mikio Shimizu Tatsusada Okuno 
supported in port by the JSPS KAKENHI(grant number 22K07539 to MS);funded by Mitsubishi Tanabe Pharma Corporation。
Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal cord.Patients with ALS develop skeletal muscle we...
关键词:PARALYSIS SCLEROSIS 
The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons
《Neural Regeneration Research》2025年第1期209-223,共15页Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang 
supported by the National Key Research and Development Program of China,No.2021ZD0202503(to AHT);the National Natural Science Foundation of China,Nos.31872759(to AHT)and 32070707(to CF);Shenzhen Science and Technology Program,No.RCJC20210609104333007(to ZW);Shenzhen-Hong Kong Institute of Brain Science,Shenzhen Fundamental Research Institutions,No.2021SHIBS0002(to ZW).
Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and memory.Kinesin-4 KIF21A helps organize the microtubule-actin network at th...
关键词:ACTIN CYTOSKELETON dendrite KANK1 KIF21A MICROTUBULE spine morphology SPINE synaptic plasticity talin1 
Roles of N-cadherin in cerebral cortical development:cooperation with membrane trafficking and actin cytoskeletal regulation
《Neural Regeneration Research》2025年第1期188-190,共3页Shiho Ito Takeshi Kawauchi 
funded by JSPS KAKENHI Grant Numbers JP26290015 and JP21H02655(to TK)from Ministry of Education,Culture,Sports,Science,and Technology of Japan(MEXT)。
Cell adhesion plays pivotal roles in the morphogenesis of multicellular organisms.Epithelial cells form several types of cell-to-cell adhesion,including zonula occludens(tight junctions),zonula adhaerens(adherens junc...
关键词:CEREBRAL SKELETAL COOPERATION 
Advances in understanding the roles of actin scaffolding and membrane trafficking in dendrite development
《Journal of Genetics and Genomics》2024年第11期1151-1161,共11页Wanting Wang Menglong Rui 
supported by the National Natural Science Foundation of China(32100784);the Natural Science Foundation of Jiangsu Province(BK20221458);the Fundamental Research Funds for the Central Universities(also known as the Southeast University Zhishan Young Scholars Program,2242024RCB0031)。
Dendritic morphology is typically highly branched,and the branching and synaptic abundance of dendrites can enhance the receptive range of neurons and the diversity of information received,thus providing the basis for...
关键词:ACTIN Membrane vesicle transport Exocyst complex Secretory pathway Dendrite development Neurological disease 
Actin(g) toward a revised understanding of the role of cytoskeletal dynamics in neuronal bioenergetics
《Neural Regeneration Research》2024年第10期2109-2110,共2页Sabrina M.Holland Gianluca Gallo 
supported by National Institute of Health awards NS118000 and NS128049 (to GG)。
Neurons are energy-demanding cells.Disruptions in energy metabolism can quickly interrupt neuronal function,leading to cell death and neurodegeneration.For instance,ischemia rapidly depletes adenosine triphosphate(ATP...
关键词:METABOLISM HOMEOSTASIS DEGENERATION 
Reaction Mechanism of Actin ATP Hydrolysis Studied by QM/MM Calculations
《Chemical Research in Chinese Universities》2024年第5期849-855,共7页WANG Yiwen LIN Lirui XU Li-Yan LI En-Min DONG Geng 
supported by the National Natural Science Foundation of China(No.21907063),the Li Ka-shing Foundation,China(No.LD0101),the 2020 Li Ka-shing Foundation Cross-Disciplinary Research Grant,China(No.2020LKSFG07B);the Innovation Team Grant of Department of Education of Guangdong Provice,China(No.2021KCXTD005);the Shantou University Medical College(SUMC)Scientific Research Initiation Grant,China(No.510858063).
Actin fibers are an important part of the cytoskeleton,providing vital support for the plasma membrane.This function is driven by its ATPase(ATP:adenosine triphosphate)activity,i.e.,ATP+H_(2)O→ADP+Pi.This seemingly s...
关键词:ACTIN Adenosine triphosphate(ATP)hydrolysis Quantum mechanical and molecular mechanics(QM/MM) Reaction mechanism 
Terpene extract from the stem of Celastrus orbiculatus inhibits actin cytoskeleton remodelling in gastric cancer cells by regulating the protein interaction between PTBP1 and ACTN4
《Journal of Pharmaceutical Analysis》2024年第8期1158-1175,共18页Zewen Chu Miao Zhu Yuanyuan Luo Yaqi Hu Xinyi Feng Jiacheng Shen Haibo Wang Masataka Sunagawa Yanqing Liu 
financially supported by the National Natural Science Foundation of China(Grant Nos.:82274603 and 82104946);the Natural Science Foundation of Jiangsu Province,China(Grant No.:BK20210817);the Traditional Chinese Medicine Science and Technology Development Project of Jiangsu Province,China(Project code:QN202008);the Young Scientific and Technological Talents Uplift Project of Jiangsu Association of Integrated Traditional Chinese and Western Medicine,China(Grant No.:JSZXTJ-2024-A05);the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(Grant No.:KYCX21_3295);the Yangzhou University Graduate Student International Academic Exchange Special Fund Project,China.Thanks for the Graphical abstract drawn。
Adjuvant chemoradiotherapy,molecular targeted therapy,and immunotherapy are frequently employed to extend the survival of patients with advanced gastric cancer(GC).However,most of these treatments have toxic side effe...
关键词:Traditional Chinese medicine Polypyrimidine tract binding protein 1 Alpha actinin-4 Gastric cancer Actin skeleton remodelling 
Dietary xylo‑oligosaccharides and arabinoxylans improved growth efficiency by reducing gut epithelial cell turnover in broiler chickens被引量:1
《Journal of Animal Science and Biotechnology》2024年第3期1325-1335,共11页Carla Castro Shahram Niknafs Gemma Gonzalez‑Ortiz Xinle Tan Michael R.Bedford Eugeni Roura 
Background One of the main roles of the intestinal mucosa is to protect against environmental hazards.Supple-mentation of xylo-oligosaccharides(XOS)is known to selectively stimulate the growth of beneficial intestinal...
关键词:ACTIN ARABINOXYLANS BROILER Cell turnover Energy metabolism JEJUNUM Xylo-oligosaccharides 
Transient induction of actin cytoskeletal remodeling associated with dedifferentiation,proliferation,and redifferentiation stimulates cardiac regeneration被引量:1
《Acta Pharmaceutica Sinica B》2024年第6期2537-2553,共17页Wenbin Fu Qiao Liao Yu Shi Wujian Liu Hongmei Ren Chunmei Xu Chunyu Zeng 
supported by the grant to Chunyu Zeng from the National Key R&D Program of China(2022YFA1104500);the National Natural Science Foundation of China(82200307);the grant to Chunyu Zeng from the National Natural Science Foundation of China(81930008).
The formation of new and functional cardiomyocytes requires a 3-step process:dedifferentiation,proliferation,and redifferentiation,but the critical genes required for efficient dedifferentiation,proliferation,and redi...
关键词:Single cell analysis Actin remodeling Tmsb4x Tmsb10 Dmd Ctnna3 Myocardial infarction Cardiomyocytes proliferation Cardiac regeneration Genetic therapy 
Analysis and Review of Downregulated Actin Cytoskeletal Proteins in Non-Small Cell Lung Cancer
《Journal of Biosciences and Medicines》2024年第4期89-115,共27页Hala M. Abdel Mageed Praveen Sahu Raji Sundararajan 
Actin, a highly conserved protein, plays a dominant role in Non-small cell lung cancer (NSCLC). Late diagnosis and the aggressive nature of NSCLC pose a significant threat. Studying the clinic pathological properties ...
关键词:Non-Small Cell Lung Cancer NSCLC ACTIN Actin Cytoskeletal Proteins Focal Adhesion KEEG Pathway 
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