Advances in understanding the roles of actin scaffolding and membrane trafficking in dendrite development  

作　　者：Wanting Wang Menglong Rui 

机构地区：[1]School of Life Science and Technology,The Key Laboratory of Developmental Genes and Human Disease,Southeast University,Nanjing,Jiangsu 210031,China

出　　处：《Journal of Genetics and Genomics》2024年第11期1151-1161,共11页遗传学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(32100784);the Natural Science Foundation of Jiangsu Province(BK20221458);the Fundamental Research Funds for the Central Universities(also known as the Southeast University Zhishan Young Scholars Program,2242024RCB0031)。

摘　　要：Dendritic morphology is typically highly branched,and the branching and synaptic abundance of dendrites can enhance the receptive range of neurons and the diversity of information received,thus providing the basis for information processing in the nervous system.Once dendritic development is aberrantly compromised or damaged,it may lead to abnormal connectivity of the neural network,affecting the function and stability of the nervous system and ultimately triggering a series of neurological disorders.Research on the regulation of dendritic developmental processes has flourished,and much progress is now being made in its regulatory mechanisms.Noteworthily,dendrites are characterized by an extremely complex dendritic arborization that cannot be attributed to individual protein functions alone,requiring a systematic analysis of the intrinsic and extrinsic signals and the coordinated roles among them.Actin cytoskeleton organization and membrane vesicle trafficking are required during dendrite development,with actin providing tracks for vesicles and vesicle trafficking in turn providing material for actin assembly.In this review,we focus on these two basic biological processes and discuss the molecular mechanisms and their synergistic effects underlying the morphogenesis of neuronal dendrites.We also offer insights and discuss strategies for the potential preventive and therapeutic treatment of neuropsychiatric disorders.

关 键 词：ACTIN Membrane vesicle transport Exocyst complex Secretory pathway Dendrite development Neurological disease 

分 类 号：Q421[生物学—神经生物学]