supported by China Scholarship Council(No.202106380078 to HL);the Netherlands Cardiovascular Research Initiative:The Dutch Heart Foundation(CVON 2018-28 and 2012-06 Heart Brain Connection to AMT)。
Cerebral small vessel disease(SVD)represents a range of pathological changes in the small blood vessels of the brain.SVD can be detected on MRI,which includes white matter hyperintensities,lacunes,and cerebral microbl...
funded by the Deutsche Forschungsgemeinschaft(DFG),the BONFOR program of the Medical Faculty of the University of Bonn,and the Alexander-von-Humboldt Foundation.
Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory functions.In only approximately 5%of the cases,AD is familial,as often predis...
supported by the National Natural Science Foundation of China(82273620,81302427)。
Identifying a potential dietary non-pharmacological treatment to prevent cerebrovascular damage in Alzheimer's disease is crucial for alleviating cognitive decline in older adults and enhancing quality of life.This st...
BACKGROUND Unilateral biportal endoscopic(UBE)surgery has developed rapidly during the past decade.Continuous epidural space irrigation is generally considered the principal reason for cerebral complications following...
supported by the National Natural Science Foundation of China(Nos.81920108017 and 82130036);the Key Research and Development Program of Jiangsu Province of China(No.BE2020620);Jiangsu Province Key Medical Discipline(No.ZDXKA2016020)。
Microglia,the resident immune cells in the central nervous system(CNS),rapidly transition from a resting to an active state in the acute phase of ischemic brain injury.This active state mediates a pro-inflammatory res...
Supported by Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences (No. CI2021B00)。
Alzheimer's disease(AD)is a prevalent neurodegenerative disorder among the elderly population,and timely intervention has been shown to effectively slow down the progression of dementia stage.(1)Although drugs such as...
supported by National Institute of Neurological Disorders and Stroke of the National Institutes of Health under award number R21NS114763;US Army Medical Research and Materiel Command (USAMRMC) under award#W81XWH-18-1-0773;merit-based career enhancement award at the Feinstein Institutes for Medical Research (to CL)
Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfus...
supported by the National Natural Science Foundation of China (32070979);Shenzhen Science and Technology Program (JCYJ20220530161604009,JCYJ20240813150734043);Key Research and Development Program of Shaanxi (2024SF,YBXM,050);Fundamental Research Funds for the Central Universities (31020190QD004,3102019YX01001);Double First-Class Project of China Pharmaceutical University (CPUQNJC22_02);Global Pharmaceutical Development Alliance Plan of China Pharmaceutical University (1302090024-05)。
DNA2,a multifunctional enzyme with structure-specific nuclease,5'-to-3'helicase,and DNA-dependent ATPase activities,plays a pivotal role in the cellular response to DNA damage.However,its involvement in cerebral ische...