Revisiting cerebral endothelial cells in Alzheimer’s disease  

作　　者：Amira S.Hanafy 

机构地区：[1]Department of Neurosurgery,University Hospital Bonn,Bonn,Germany

出　　处：《Neural Regeneration Research》2025年第10期2911-2912,共2页中国神经再生研究（英文版）

基　　金：funded by the Deutsche Forschungsgemeinschaft(DFG),the BONFOR program of the Medical Faculty of the University of Bonn,and the Alexander-von-Humboldt Foundation.

摘　　要：Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory functions.In only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the cases.The amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关 键 词：ALZHEIMER AΒ CEREBRAL 

分 类 号：R749.16[医药卫生—神经病学与精神病学]