DYSFUNCTION

作品数：891被引量：2481H指数：20
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Biomarkers for synaptic dysfunction in Alzheimer’s disease
《Neural Regeneration Research》2026年第2期683-684,共2页Ruiqing Ni 
supported by Swiss Center for Applied Human Toxicology(SCAHT AP22-01)(to RN).
Alzheimer’s disease(AD)is the most common cause of dementia,characterized by progressive cognitive decline,and affects over 55 million people worldwide.AD is pathological featured by the aberrant accumulation of amyl...
关键词：vivo autopsy studies synaptic dysfunction loss alzheimer s disease ad amyloid plaques cognitive declineand Alzheimers disease dysfunction neurotransmitter systemsevidence synaptic dysfunction 
Cognition,apathy,and gait dysfunction in cerebral small vessel disease:A shared neural basis?
《Neural Regeneration Research》2026年第1期302-303,共2页Hao Li Mengfei Cai Anil Man Tuladhar 
supported by China Scholarship Council(No.202106380078 to HL);the Netherlands Cardiovascular Research Initiative:The Dutch Heart Foundation(CVON 2018-28 and 2012-06 Heart Brain Connection to AMT)。
Cerebral small vessel disease(SVD)represents a range of pathological changes in the small blood vessels of the brain.SVD can be detected on MRI,which includes white matter hyperintensities,lacunes,and cerebral microbl...
关键词：CEREBRAL DYSFUNCTION 
Transcription factors,metabolic dysfunction-associated fatty liver disease,and therapeutic implications
《Genes & Diseases》2025年第3期137-145,共9页Shuwei Hu Yingjie Ai Chencheng Hu Fathima N.Cassim Bawa Yanyong Xu 
supported by the National Natural Science Foundation of China(No.32271218 to Y.X.).
Metabolic dysfunction-associated fatty liver disease(MAFLD)encompasses a spectrum of liver diseases ranging from metabolic dysfunction-associated fatty liver to metabolic dysfunction-associated steatohepatitis,which m...
关键词：Apoptosis FIBROSIS Inflammation MAFLD STEATOSIS Transcription factors 
Fenofibrate mitigates the dysfunction of high glucosedriven human retinal microvascular endothelial cells by suppressing NLRP3 inflammasome
《International Journal of Ophthalmology(English edition)》2025年第5期792-801,共10页Yi Shi Hao-Min Chen Ai-Hua Liu Xiao-Rong Li 
Supported by grants from the Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK-037A).
AIM:To determine the therapeutic benefits of fenofibrate(Feno)on the dysfunction of high glucose(HG)-induced human retinal microvascular endothelial cells(HRMECs)and to elucidate the underlying molecular mechanism.MET...
关键词：FENOFIBRATE human retinal microvascular endothelial cells high glucose NOD-like receptor thermal protein domain associated protein 3 inflammasomes oxidative stress 
Microglial dysfunction and genetic risk for neurodegenerative disease
《Neural Regeneration Research》2025年第5期1401-1402,共2页Debra S.MacDonald Jay Penney 
supported by a Canada Research Chair award to JP。
Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations age.While tremendous progress has been made,our understanding of the mechanisms that underlie...
关键词：DEGENERATIVE DISEASES 
Risks of liver cirrhosis,hepatocellular carcinoma,hepatic-related complications,and mortality in patients with type 2 diabetes in Taiwan
《World Journal of Diabetes》2025年第5期202-215,共14页Hua-Fen Chen Yung-Yueh Chang Peter Chen Xiao-Han Shen Chin-Huan Chang Wan-Lun Hsu 
Supported by The Far Eastern Memorial Hospital,No.FEMH-2022-C-015,No.FEMH-2022-C-017 and No.FEMH-2023-C-082.
BACKGROUND Hepatitis B and C and alcoholic liver disease are the principal causes of hepaticrelated morbidity and mortality.However,evidence of the associations between diabetes without the above risk factors and hepa...
关键词：Type 2 diabetes mellitus Liver cirrhosis Hepatocellular carcinoma Hepatic-related complications MORTALITY Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis 
TERT/FOXO1 signaling promotes isletβ-cell dysfunction in type 2 diabetes mellitus by regulating ATG9A-mediated autophagy
《World Journal of Diabetes》2025年第5期317-330,共14页Xiao-Tian Lei Xiang-Fen Chen Sheng Qiu Jia-Ying Tang Shan Geng Gang-Yi Yang Qi-Nan Wu 
Supported by National Natural Science Foundation of China,No.82000792;General Project of Chongqing Natural Science Foundation,No.CSTB2023NSCQ-MSX0246 and No.CSTB2022NSCQ-MSX1271;Research Project of the State Administration of Traditional Chinese Medicine on Collaborative Chronic Disease Management of Traditional Chinese Medicine and Western Medicine,No.CXZH2024087;Science and Health Joint Project of Dazu District Science and Technology Bureau,No.DZKJ2024JSYJ-KWXM1002.
BACKGROUND Type 2 diabetes mellitus(T2DM)is a severe global health problem that causes prolonged disease exposure and an elevated risk for chronic complications,posing a substantial health burden.Although therapies,su...
关键词：TERT ATG9A AUTOPHAGY Isletβ-cells Type 2 diabetes mellitus 
Unlocking the secrets of exercise:A pathway to enhanced insulin sensitivity and skeletal muscle health in type 2 diabetes
《Journal of Sport and Health Science》2025年第2期71-74,共4页Juleen R.Zierath Aidan J.Brady Kirstin A.Macgregor Joaquin Ortiz de Zevallos Ben Stocks 
supported by the Swedish Research Council(201500165);a Wallenberg Scholars Award from the Knut and Alice Wallenberg Foundation(KAW 2023.0312);The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent research center at the University of Copenhagen,partially funded by an unrestricted donation from the Novo Nordisk Foundation(NNF23SA0084103).
1.Exercise enhances muscle function and insulin sensitivity Skeletal muscle plays a fundamental role in not only locomotion,but also systemic metabolism.In people with type 2 diabetes,skeletal muscle is a major site o...
关键词：impaired insulin signaling metabolic dysfunction muscle function type diabetes insulin sensitivity reduced glucose transport activity skeletal muscle 
Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration被引量：1
《Neural Regeneration Research》2025年第4期1069-1076,共8页Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih Hung Lo Jialiu Zeng 
supported by a Presidential Postdoctoral Fellowship (021229-00001) from Nanyang Technological University,Singapore (to JZ);a Lee Kong Chian School of Medicine Dean’s Postdoctoral Fellowship (021207-00001) from NTU Singapore;a Mistletoe Research Fellowship (022522-00001) from the Momental Foundaton,USA (to CHL)
The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.Obesity-related conditions like type 2 d...
关键词：Alzheimer’s disease inflammatory cytokines insulin resistance LIPID 
Helicobacter pylori infection is linked to metabolic dysfunction and associated steatotic liver disease:A large cross-sectional study
《World Journal of Gastroenterology》2025年第13期79-88,共10页Lin Ye Kai Yan Ze Tian Zhi-Hua Xiao Ru-Yi Xie Zheng-Yuan Xie Li Tao 
Supported by Science and Technology Research Program of Jiangxi Provincial Department of Education,No.GJJ210225;2022 Provincial Health and Wellness Committee Science and Technology Program Projects,No.20221096;Jiangxi Provincial Natural Science Foundation's Young Scientists Fund,No.20242BAB20358.
BACKGROUND Helicobacter pylori(H.pylori),a globally widespread pathogen affecting half of the global population,has been increasingly implicated in metabolic disorders,including obesity,dyslipidemia,and metabolic dysf...
关键词：Helicobacter pylori OBESITY Blood glucose Lipid profile Blood pressure Metabolic dysfunction-associated steatotic liver disease 
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