PHENOTYPE

作品数：578被引量：1611H指数：18
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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease
《Neural Regeneration Research》2025年第8期2361-2372,共12页Shengyang Zhou Ting Li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen 
supported by the National Natural Science Foundation of China,Nos.82171429,81771384;a grant from Wuxi Municipal Health Commission,No.1286010241190480(all to YS)。
Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report tha...
关键词：cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease NEUROINFLAMMATION Parkinson’s disease RU521 STING type I interferon 
Preclinical ex vivo IL2RG gene therapy using autologous hematopoietic stem cells as an effective and safe treatment for X-linked severe combined immunodeficiency disease
《Genes & Diseases》2025年第3期397-410,共14页Mingfeng Hu Qiling Xu Fang Zhang Karen F.Buckland Yelei Gao Weixia Du Yuan Ding Lina Zhou Xiulian Sun Lijia Ma Zhiyong Zhang Xuemei Tang Xiaodong Zhao Adrian J.Thrasher Yunfei An 
supported by the National Natural Science Foundation of China(No.82070135);the National Key R&D Program of China(No.2021YFC2700804);the CQMU Program for Youth Innovation in Future Medicine(China)(No.W0100).
X-linked severe combined immunodeficiency disease(X-SCID)is a rare inheriteddisease caused by mutations in the interleukin 2 receptor subunit gamma gene(IL2RG),whichencodes the common g chain protein,a subunit of the ...
关键词：Atypicaldiverse phenotype Gene therapy IL2RG Self-inactivating lentiviral vector X-linked severe combined immunodeficiency disease 
Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy
《Acta Pharmacologica Sinica》2025年第4期951-963,共13页Bu-chun Zhang Wen-ya Zhu Sheng-nan Wang Meng-meng Zhu Hui Ma Liang Dong Xiao-xiao Yang Chuan-rui Ma Li-kun Ma Yuan-li Chen 
supported by the National Natural Science Foundation of China(NSFC)grants(Grant No.U22A20272 to YLC);Anhui Provincial Natural Science Foundation(Grant No.2308085MH240 to YLC,2208085MH196 to BCZ);Pilot Demonstration Project for the Inheritance and Innovative Development of Traditional Chinese Medicine in Nankai District,Tianjin(20240204007 to CRM).
Vascular smooth muscle cell(VSMC)phenotype transformation significantly contributes to vascular intimal hyperplasia.However,effective preventive and therapeutic measures are lacking.Colchicine,a binary alkaloid derive...
关键词：neointima formation COLCHICINE VSMC FOXO3A AUTOPHAGY 
Inter-and intraspecific variation in flight muscle fibers is associated with migratory timing
《Avian Research》2025年第1期30-38,共9页Shangmingyu Zhang Shane DuBay Yuwen Cheng Zhehan Dong Zhengwei Liu Yongjie Wu 
financially supported by the National Natural Science Foundation of China (No.32270454);by the Survey of Wildlife Resources in Key Areas of Tibet (ZL202203601)。
The life-history strategies of organisms are shaped by trade-offs among traits that influence survival,development,reproduction,and ultimately fitness.However,the specific physiological and environmental mechanisms dr...
关键词：Elevational migration Intraspecific variation Muscle fiber PHENOTYPE Small-bodied birds 
Rosaceae phylogenomic studies provide insights into the evolution of new genes
《Horticultural Plant Journal》2025年第1期389-405,共17页Lan Jiang Xiaoxu Li Kun Lyu Han Wang Zhiyuan Li Wang Qi Lin Zhang Yunpeng Cao 
supported by the National Natural Science Foundation of China(Grant Nos.32201602,82304680);the Natural Science Fund of Hubei Province(Grant No.2023AFB1036);the Program for Excellent Sci-tech Innovation Teams of Universities in Anhui Province(Grant No.2022AH010074);Anhui Provincial Natural Science Foundation(Grant No.2308085QH295);Natural Science Research Project of Anhui Educational Committee(Grant No.2023AH040259);the Talent Scientific Research Startup Foundation,Wannan Medical College(Grant No.YR20230110);the Anhui Provincial Department of Education Young Backbone Teachers Overseas Visiting and Training Funding Program(Grant No.JWFX2023033);Beijing Life Science Academy Project(Grant No.2023200CC0270)。
Rosa banksiae,known as Lady Banks'rose,is a perennial ornamental crop and a versatile herb in traditional Chinese medicine.Given the lack of genomic resources,we assembled a Hi Fi and Nanopore sequencing-derived 458.5...
关键词：Rosa banksiae Gap-free genome ROSACEAE PHENOTYPE Evolutionary patterns 
Integrated metabolomics and proteomics analyses reveal the molecular mechanism underlying the yellow leaf phenotype of Camellia sinensis被引量：1
《Horticultural Plant Journal》2025年第1期417-430,共14页Nana Li Weizhong He Yufan Ye Mingming He Taimei Di Xinyuan Hao Changqing Ding Yajun Yang Lu Wang Xinchao Wang 
supported by the Project for Collaborative Promotion of Agricultural Major Technology of Zhejiang Province(Grant No.2022XTTGCY01-02);the National Natural Science Foundation of China(Grant Nos.31700615,32172633);the China Agriculture Research System of MOF and MARA(Grant No.CARS19-01A);the Special Project of Zhejiang Province(Grant No.2020R52036)。
The tea plant cultivar‘Zhonghuang 2'(ZH2)possesses albino-induced yellow leaves that contain low levels of catechins but high contents of amino acids.However,the molecular mechanism underlying the yellow leaf phenoty...
关键词：Tea plant Chlorophyll-deficient mutant Chlorophyll biosynthesis Photosynthetic protein Antioxidant capacity Photooxidative stress 
Suppression of Cell Traction Force and Enhanced Force Polarity are Key Factors in Vascular Smooth Muscle Cell Differentiation Induced by Low Serum Culture
《Journal of Biosciences and Medicines》2025年第2期243-255,共13页Kazuaki Nagayama Harunobu Tatsuno 
Vascular smooth muscle cells (VSMCs) in the arterial walls play important roles in regulating vascular contraction and dilation. VSMCs actively remodel the arterial walls and dedifferentiate from the contractile to th...
关键词：Cell Biomechanics MECHANOBIOLOGY PHENOTYPE CYTOSKELETON Traction Force Microscopy 
Relationship between gastric mucosal atrophy by endoscopy and non-ampullary duodenal epithelial tumors
《World Journal of Gastrointestinal Oncology》2025年第2期84-92,共9页Kazuya Ohno Eiji Nakatani Takafumi Kurokami Asami Kawai Ryosuke Itai Masanori Matsuda Yuichi Masui Tatsunori Satoh Shinya Ikeda Taiyo Hirata Shodai Takeda Makoto Suzuki Ken Haruma 
BACKGROUND The pathogenesis of non-ampullary duodenal epithelial tumors(NADETs)is not fully understood.NADETs that express gastric-type mucin phenotypes(GNADETs)are noteworthy because of their high malignancy.Gastric ...
关键词：Gastric acidity Gastric foveolar metaplasia Gastric mucosal atrophy Helicobacter pylori Mucin phenotype Nonampullary duodenal epithelial tumor 
Molecular breakthroughs in modern plant breeding techniques
《Horticultural Plant Journal》2025年第1期15-41,共27页Mughair Abdul Aziz Khaled Masmoudi 
funded by the United Arab Emirates University;Research Office;grant number 12F041 to KM。
Advancements in molecular approaches have been utilized to breed crops with a wide range of economically valuable traits to develop superior cultivars.This review provides a concise overview of modern breakthroughs in...
关键词：Plant breeding Molecular approaches GENOTYPE PHENOTYPE Crop traits 
Targeted tilianin lipid nanoparticles for the treatment of atherosclerosis through remodeling lesional macrophage phenotype
《Nano Research》2025年第2期571-585,共15页Yaoyao Luo Zhongshan He Mengran Guo Xinchun Wang Zhaohui Jin Min Sun Huiling Yang Wanqin Zeng Shengbin Liu Yupei Zhang Guohong Li Xiaoling Yin Shugang Qin Xing Duan Yong'an Hu Xiangrong Song 
This research was supported by the Science and Technology Project of Xinjiang Production and Construction Corps(No.2022AB020);the Youth Fund of National Natural Science Foundation of China(Nos.82104081 and 82400537);the Sichuan Province Science and Technology Support Program(No.2023NSFSC1682,and No.2024NSFSC0714,Zhongshan He);the Postdoctoral Fellowship Program of CPSF under Grant(No.GZC20241133,Zhongshan He);the Sichuan University Postdoctoral Research and Development Fund(No.2024SCU12014);the West China Hospital Postdoctoral Research and Development Fund(No.2024HXBH058);the Sichuan University Postdoctoral Interdisciplinary Innovation Fund(No.JCXK2203).
Remodeling of the lesional macrophages in atherosclerotic plaques from pro-inflammatory M1 to pro-resolving M2 phenotype is emerging as a promising approach to atherosclerosis treatment.Tilianin(Til),as a natural plan...
关键词：ATHEROSCLEROSIS tilianin lipid nanoparticles M1 to M2 remodeling lesional macrophage-targeted 
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