云南高校图书馆联盟文献共享服务平台- VSMC

VSMC: 作品数：212被引量：587H指数：10; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：韩梅何国祥刘建平景涛温进坤更多>>; 相关机构：河北医科大学华中科技大学天津医科大学武汉大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划河北省自然科学基金湖北省自然科学基金更多>>

Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy: 《Acta Pharmacologica Sinica》2025年第4期951-963,共13页Bu-chun Zhang Wen-ya Zhu Sheng-nan Wang Meng-meng Zhu Hui Ma Liang Dong Xiao-xiao Yang Chuan-rui Ma Li-kun Ma Yuan-li Chen; supported by the National Natural Science Foundation of China(NSFC)grants(Grant No.U22A20272 to YLC);Anhui Provincial Natural Science Foundation(Grant No.2308085MH240 to YLC,2208085MH196 to BCZ);Pilot Demonstration Project for the Inheritance and Innovative Development of Traditional Chinese Medicine in Nankai District,Tianjin(20240204007 to CRM).; Vascular smooth muscle cell(VSMC)phenotype transformation significantly contributes to vascular intimal hyperplasia.However,effective preventive and therapeutic measures are lacking.Colchicine,a binary alkaloid derive...; 关键词：neointima formation COLCHICINE VSMC FOXO3A AUTOPHAGY

Cucurbitacins mitigate vascular neointimal hyperplasia by suppressing cyclin A2 expression and inhibiting VSMC proliferation: 《Animal Models and Experimental Medicine》2024年第4期397-407,共11页Ruqiang Yuan Lei Qian Hu Xu Weijing Yun; Scientific Research Fund Project of Liaoning Provincial Department of Education,Grant/Award Number:LJKMZ20221267,LJKZ0840 and LJKZ0847;National Natural Science Foundation of China Grants,Grant/Award Number:81900267。; Background:Restenosis frequently occurs after percutaneous angioplasty in patients with vascular occlusion and seriously threatens their health.Substantial evidence has revealed that preventing vascular smooth muscle ...; 关键词：CuB CUCURBITACIN cyclin A2 RESTENOSIS vascular smooth muscle cell

Syndecan-4响应基底刚度调节VSMC向“合成型”转化的力生物学机制: 《医用生物力学》2024年第S01期103-103,共1页贺靖钦何疆谭霞张萧元张涛; 重庆市博士后特别资助项目,2022CQB SHTB3064;重庆市自然科学基金面上项目,CSTB2023NSCQ-MSX0143; 目的基底硬度变化对血管平滑肌细胞(VSMCs)从“收缩型”向“合成型”转化的力-生物学机制尚未完全清楚。方法本文通过分离早期、晚期动脉粥样硬化模型小鼠(ApoE^(-/-))的VSMCs,提取细胞膜蛋白及脂筏组分,结合串联质谱和蛋白组学分析,比...; 关键词：病灶区合成型生物学机制表型转化平滑肌细胞血管平滑肌基底刚度细胞膜蛋白

心血管纳米医学在血管平滑肌细胞中的应用: 《生命科学研究》2024年第3期215-222,共8页余玉庄何宛欣徐紫薇陈金燕郭颖欣李华琴; 广东省大学生创新训练项目(基于高血压模型挖掘调控血管平滑肌细胞转换的候选基因和miRNAs)(S202113902016)。; 血管平滑肌细胞(vascular smooth muscle cell, VSMC)具有调节血管紧张性和维持血管形态的功能,其功能障碍与心血管疾病的发生、发展密切相关。纳米医学(nanomedicine)是指纳米材料在医学中的应用,因其能够克服传统治疗方式存在的药理...; 关键词：血管平滑肌细胞(VSMC) 心血管疾病纳米医学高血压纳米材料

FGF21 overexpression alleviates VSMC senescence in diabetic mice by modulating the SYK-NLRP3 inflammasome-PPARγ-catalase pathway: 《Acta Biochimica et Biophysica Sinica》2024年第6期892-904,共13页Yanyan Heng Wei Wei Linzhong Cheng Feifei Wu Haoyu Dong Jingxia Li Jianing Fu Bingjie Yang Xinyue Liang Chunyan Liu Haiju Li Haihua Liu Pengfei Zhang; supported by the grants from the Projects of Heping Hospital Affiliated to Changzhi Medical College(Nos.HPYJ201921,HPYJ202218,HPYJ202210);the Scientific and Technological Innovation Programs(STIP)of Higher Education Institutions in Shanxi(No.2021L351);the Research Fund of Changzhi Medical College(No.BS202115);the Department of Science and Technology of Shanxi(No.202203021211107);the Health Commission of Shanxi Province(No.2022021).; Diabetes accelerates vascular senescence,which is the basis for atherosclerosis and stiffness.The activation of the NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome and oxidative stress are closel...; 关键词：vascular smooth muscle cell SENESCENCE NLRP3 inflammasome PPARγ CATALASE

雷帕霉素对慢性肾衰竭大鼠主动脉平滑肌细胞钙化及自噬的影响: 《中国老年学杂志》2024年第4期906-911,共6页郑金花韦泽丰王自强; 海南省卫生健康行业科研项目(2001320243A2004)。; 目的探讨雷帕霉素抑制剂对慢性肾衰竭平滑肌细胞(VSMC)钙化的影响机制。方法取33只雄性昆明大鼠自由饮用2%葡聚糖硫酸钠(DSS)水溶液共7 d,普通饮水14 d。随机选取3只大鼠取肾脏组织进行病理学检查,其余30只随机分为模型组、CRF+I组和CRF...; 关键词：雷帕霉素血管平滑肌细胞(VSMC) 血管钙化自噬

Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling被引量：3: 《Acta Pharmacologica Sinica》2024年第1期98-111,共14页Shuang Yang Hou-wei Li Jia-ying Tian Zheng-kai Wang Yi Chen Ting-ting Zhan Chun-yue Ma Min Feng Shifeng Cao Yu Zhao Xue Li Jing Ren Qian Liu Lu-ying Jin Zhi-qi Wang Wen-yu Jiang Yi-xiu Zhao Yan Zhang Xue Liu; supported by National Natural Science Foundation of China(82170431,81870259,81903608).; Restenosis after angioplasty is caused usually by neointima formation characterized by aberrant vascular smooth muscle cell(VSMC)dedifferentiation.Myeloid-derived growth factor(MYDGF),secreted from bone marrow-derived...; 关键词：carotid artery balloon injury neointimal formation VSMC dedifferentiation MYDGF Sphingosine-1-phosphate receptor 2

Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes被引量：2: 《Acta Pharmacologica Sinica》2023年第2期345-355,共11页Chun-ling Huang Yu-na Huang Lei Yao Jun-ping Li Zeng-hui Zhang Zhao-qi Huang Si-xu Chen Yu-ling Zhang Jing-feng Wang Yang-xin Chen Zhao-yu Liu; supported by grants from the National Natural Sclence Foundation of China(82170492,81900387);Guangdong Basic and Applied Basic Research Found(2019A15150118061);Science and Technology Program of Guangzhou City of China(202102010302).; Abdominal aortic aneurysm(AAA)is a dangerous vascular disease without any effective drug therapies so far.Emerging evidence suggests the phenotypic differences in perivascular adipose tissue(PVAT)between regions of th...; 关键词：abdominal aortic aneurysm perivascular adipose tissue BROWNING vascular smooth muscle cells APOPTOSIS SECRETOME

Platelet-derived microvesicles deliver miR-30e and promote VSMC apoptosis after balloon injury: 《Medicine in Novel Technology and Devices》2022年第1期22-30,共9页Li Zi-Tong Chen Yuan-Xiu Bao Han Liu Ji-Ting Zhuang Fei Li Hai-Peng Yao Qing-Ping Jiang Zong-Lai Qi Ying-Xin; This research was supported by grants from the National Natural Science Foundation of China,No.11625209.; During vascular remodeling after intimal injury,circulating platelets are activated by exposed collagen and release platelet-derived microvesicles(PMVs),which may contribute to the injury-induced apoptosis of vascular...; 关键词：Platelet-derived microvesicles Vascular smooth muscle cells APOPTOSIS miR-30e RUNX2 Intimal injury

VSMC-Cx43^(-/-)条件性基因敲除小鼠模型的构建及基因型鉴定: 《环境卫生学杂志》2022年第1期18-24,共7页秦小江侯晓敏许欣荣柴丽娜杨晓宇赵良渊杜旭峰施熠炜; 国家自然科学基金青年基金(81803282);细胞生理学教育部重点实验室(山西医科大学)开放基金(CPOF202109);山西省归国留学基金项目(2020-086,2020-075,2020-167)。; 目的应用CRISPR-Cas9技术和LoxP-Cre系统构建血管平滑肌缝隙连接蛋白Cx43条件性基因敲除小鼠(VSMC-Cx43^(-/-))模型。方法采用受精卵同源重组的方式,对Gja1基因进行flox修饰。通过体外转录的方式,获得Cas9 mRNA和gRNA;通过In-Fusion clo...; 关键词：缝隙连接蛋白43(Cx43) 基因敲除小鼠基因型鉴定

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