COLCHICINE

作品数：69被引量：147H指数：6
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相关机构：华中农业大学北京林业大学华中科技大学同济医学院附属同济医院中国医药学院更多>>
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Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy
《Acta Pharmacologica Sinica》2025年第4期951-963,共13页Bu-chun Zhang Wen-ya Zhu Sheng-nan Wang Meng-meng Zhu Hui Ma Liang Dong Xiao-xiao Yang Chuan-rui Ma Li-kun Ma Yuan-li Chen 
supported by the National Natural Science Foundation of China(NSFC)grants(Grant No.U22A20272 to YLC);Anhui Provincial Natural Science Foundation(Grant No.2308085MH240 to YLC,2208085MH196 to BCZ);Pilot Demonstration Project for the Inheritance and Innovative Development of Traditional Chinese Medicine in Nankai District,Tianjin(20240204007 to CRM).
Vascular smooth muscle cell(VSMC)phenotype transformation significantly contributes to vascular intimal hyperplasia.However,effective preventive and therapeutic measures are lacking.Colchicine,a binary alkaloid derive...
关键词：neointima formation COLCHICINE VSMC FOXO3A AUTOPHAGY 
Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors
《Acta Pharmacologica Sinica》2025年第3期702-714,共13页Lin-hui Zhai Xing-long Jia Yu-lu Chen Mu-yin Liu Jing-dan Zhang Shao-jie Ma Xiu-jun Wang Wen-hao Cheng Jing-liang He Jiao-jiao Zhou Ling-yi Zuo Mei-qi Zhang Qing Yuan Meng-han Xu Jing Ji Min-jia Tan Bin Liu 
supported by grants from the National Natural Science Foundation of China(82273167,22225702,32171434);the Program of Shanghai Academic Research Leader(22XD1420900);the State Key Laboratory of Drug Research(SIMM2105KF-13);Jiangsu Province Basic Research Program Natural Science Foundation(Outstanding Youth Fund Project,BK20220063);the Key Program of Basic Science(Natural Science)of Jiangsu Province(22KJA350001);“Huaguo Mountain Talent Plan”of Lianyungang City(Innovative Talents to Bin Liu).
Colchicine is a widely prescribed anti-inflammatory drug for the treatment of gout,familial Mediterranean fever and pericarditis,but its narrow therapeutic window presents a significant risk of severe toxicity.Despite...
关键词：COLCHICINE MLN4924 multi-omics analysis PHOSPHOPROTEOMICS ubiquitinomics kinase inhibitor 
N-Benzyl arylamide derivatives as novel and potent tubulin polymerization inhibitors against gastric cancers:Design,structure-activity relationships and biological evaluations
《Chinese Chemical Letters》2025年第2期228-233,共6页Jian Song Shenghui Wang Qiuge Liu Xiao Wang Shuo Yuan Hongmin Liu Saiyang Zhang 
supported by the National Natural Science Foundation of China(Nos.82273782 and U2004123);Training Program for Young Key Teachers of Colleges and Universities in Henan Province(No.2023GGJS008)。
In this work,we employed a ring-opening strategy to develop a series of novel N-benzyl arylamide derivatives as tubulin polymerization inhibitors.Notably,13n(MY-1388)exhibited remarkable antiproliferative potency on f...
关键词：TUBULIN Colchicine binding site CA-4 N-Benzyl arylamide Antiproliferative activities 
Vitamin and zeatin treatments promote colchicine-induced haploid chromosome doubling in maize
《The Crop Journal》2024年第6期1677-1685,共9页Chen Chen Yuling Zhang Chenxu Liu Jinlong Li Jiuran Zhao Yuandong Wang Shaojiang Chen 
supported by the Science and Technology Innovation 2030-Major Project (2023ZD0403001);China Agriculture Research System (CARS-02);Beijing Academy of Agriculture and Forestry Sciences Excellent Scientist Training Program (JKZX202202);National Natural Science Foundation of China (32001554);Beijing Academy of Agriculture and Forestry Sciences Science and Technology Innovation Capability Improvement Project (KJCX20230103);Chinese Universities Scientific Fund (2022TC141).
Doubled haploid(DH)technology is an efficient method used in commercial maize breeding.Chromosome doubling is a vital step of DH technology;however,the underlying processes regulating chromosome doubling of haploid is...
关键词：Antimitotic reagent Artificial chromosome doubling Transcriptomic METABOLOMIC MAIZE 
Production of autotetraploid plants by in vitro chromosome engineering in Allium hirtifolium被引量：1
《Horticultural Plant Journal》2023年第5期986-998,共13页Nasrin Farhadi Jaber Panahandeh Alireza Motallebi-Azar Sam Mokhtarzadeh 
This project was supported by the vice chancellery of research and technology of the University of Tabriz as the PhD.thesis of Nasrin Farhadi.
Persian shallot has been propagated vegetatively through daughter bulbs and has a narrow genetic base.In the present study,to create genetic diversity in terms of ploidy level,the effects of in vitro polyploidization ...
关键词：Persian shallot Allium hirtifolium POLYPLOIDY COLCHICINE ORYZALIN Molecular marker 
Rapidly separating dissolving microneedles with sustained-release colchicine and stabilized uricase for simplified long-term gout management被引量：2
《Acta Pharmaceutica Sinica B》2023年第8期3454-3470,共17页Yao Yang Zimu Li Ping Huang Jiachan Lin Jinyuan Li Kexin Shi Jiahui Lin Jingwen Hu Zhuoxian Zhao Yongkang Yu Hongzhong Chen Xiaowei Zeng Lin Mei 
the financial support from the National Natural Science Foundation(NOs.32071342,and 82272154,China);Guangdong Special Support Program(NO.2019TQ05Y209,China);the Natural Science Foundation of Guangdong Province(NO.2023A1515012015,China);Tianjin Science Fund for Distinguished Young Scholars(NO.22JCJQJC00120,China);Natural Science Foundation of Tianjin(The Basic Research Cooperation Special Foundation of Beijing-Tianjin-Hebei Region,NO.22JCZXJC00060,China);the Fundamental Research Funds for the Central Universities(NO.2021-RC310-005,China);Technology&Innovation Commission of Shenzhen Municipality(NOs.JCYJ20220818102810023,JCYJ20190807153601667,and JCYJ20210324124402006,China);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(NOs.2021-I2M-1e058,and 2022-I2M-2-003,China)。
Despite growing prevalence and incidence,the management of gout remains suboptimal.The intermittent nature of the gout makes the long-term urate-lowering therapy(ULT)particularly important for gout management.However,...
关键词：MICRONEEDLES COLCHICINE SUSTAINED-RELEASE URICASE Liposome Transdermal administration Gout management Long-term urate-lowering therapy 
Evaluation of the effect of shodhana(detoxification)process using chromatographic profiling(HPTLC,HPLC,LC-MS,and GC-MS)and estimation of the content of toxic colchicine in Gloriosa superba Linn.tubers
《Asian Journal of Traditional Medicines》2023年第4期143-162,共20页Ajay Kumar Meena Poorna Venktaraman Mohit Motiwale Ravindra Singh Kusuma Ganji N.Srikanth K.S.Dhiman 
Shodhana(purification/detoxification)is an important aspect of Ayurveda.It has been described in several important pieces of literature.In this study,we performed shodhana process on Langali(Gloriosa superba Linn.)tub...
关键词：Shodhana HPLC LC-MS GC-MS COLCHICINE Gloriosa superba toxicity AYURVEDA 
In vitro and in vivo anticancer potential and molecular targets of the new colchicine analog ⅢM-067被引量：1
《Journal of Integrative Medicine》2023年第1期62-76,共15页Sumera Malik Mubashir J.Mintoo Chilakala Nagarjuna Reddy Rajesh Kumar Pankul Kotwal Sandip BBharate Utpal Nandi Dilip M.Mondhe Sanket K.Shukla 
Sumera Malik acknowledges the University Grants Commission for senior research fellowship(GAP-1128);Dr.Sanket K.Shukla acknowledges the SERB-DST for Ramanujan Fellowship(SB/S2/RJN-078/2019)and project(GAP-2194).
Objective: The current study evaluated various new colchicine analogs for their anticancer activity and to study the primary mechanism of apoptosis and in vivo antitumor activity of the analogs with selective anticanc...
关键词：COLCHICINE 1IIM-067 APOPTOSIS Antineoplastic agents CARCINOMA Ehrlich tumor A549 cells 
Therapeutic potential of colchicine in cardiovascular medicine:a pharmacological review被引量：12
《Acta Pharmacologica Sinica》2022年第9期2173-2190,共18页Fan-shun Zhang Qing-ze He Chengxue Helena Qin Peter JLittle Jian-ping Weng Suo-wen Xu 
This study was supported by grants from National Natural Science Foundation of China(Grant Nos.82070464,and Anhui Provincial Key Research and Development Program(Grant No.202104j07020051);Figure 2 was created using elements from Servier Medical Arts;This study was also supported by grants from National Key R&D Program of China(Grant No.2021YFC2500500);National Natural Science Foundation of China(Grant Nos.81941022,815300254);Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB38010100);This work was also supported by the Program for Innovative Research Team of The First Affiliated Hospital of USTC(Grant No.CXGG02);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(Grant No.2017BT01S131);Hefei Comprehensive National Science Center(Grant No.BJ9100000005);Hefei Municipal Development and Reform Commission.
Colchicine is an ancient herbal drug derived from Colchicum autumnale.It was first used to treat familial Mediterranean fever and gout.Based on its unique efficacy as an anti-inflammatory agent,colchicine has been use...
关键词：COLCHICINE anti-inflammatory drug cardiovascular diseases coronary artery disease atherosclerosis recurrent pericarditis RESTENOSIS heart failure myocardial infarction cardiovascular complications of COVID-19 MICROTUBULES NF-κB NLRP3 inflammas 
Genome-wide analysis of microRNAs induced and regulated by colchicine in mulberry被引量：1
《BIOCELL》2022年第8期1935-1945,共11页MENGMENG WU PENG GUO YISU SHI DANYAN ZHENG QIAONAN ZHANG XIN JIN YUHUA WANG QIANG LIN RONGJUN FANG WEIGUO ZHAO 
This work was supported by China Agriculture Research System of MOF and MARA,National Key R&D Program of China,Key Projects of International Scientific and Technological Innovation Cooperation(2021YFE0111100);Guangxi Innovation-Driven Development Project(AA19182012-2);Zhenjiang Science and Technology Support Project(GJ2021015).
A variety of plants were colchicine treated to double their chromosome number.Chromosomes are genetic carriers that determine the individual traits of organisms.The doubling of chromosomes will lead to modifications i...
关键词：Chromosomes Novel_77 QRT-PCR Target genes COLCHICINE 
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