Therapeutic potential of colchicine in cardiovascular medicine:a pharmacological review  

作　　者：Fan-shun Zhang Qing-ze He Chengxue Helena Qin Peter JLittle Jian-ping Weng Suo-wen Xu 

机构地区：[1]Institute of Endocrine and Metabolic Diseases,The First Affiliated Hospital of USTC,Division of Life Science and Medicine,University of Science and Technology of China,Hefei 230001,China [2]Faculty of Pharmacy and Pharmaceutical Sciences,Monash Institute of Pharmaceutical Sciences,Monash University(Parkville Campus),381 Royal Parade,Parkville 3052 VIC,Australia [3]Sunshine Coast Health Institute,University of the Sunshine Coast,Birtinya 4575 QLD,Australia [4]School of Pharmacy,The University of Queensland,Woolloongabba 4102 QLD,Australia [5]Biomedical Sciences and Health Laboratory of Anhui Province,University of Science&Technology of China,Hefei 230027,China

出　　处：《Acta Pharmacologica Sinica》2022年第9期2173-2190,共18页中国药理学报（英文版）

基　　金：This study was supported by grants from National Natural Science Foundation of China(Grant Nos.82070464,and Anhui Provincial Key Research and Development Program(Grant No.202104j07020051);Figure 2 was created using elements from Servier Medical Arts;This study was also supported by grants from National Key R&D Program of China(Grant No.2021YFC2500500);National Natural Science Foundation of China(Grant Nos.81941022,815300254);Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB38010100);This work was also supported by the Program for Innovative Research Team of The First Affiliated Hospital of USTC(Grant No.CXGG02);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(Grant No.2017BT01S131);Hefei Comprehensive National Science Center(Grant No.BJ9100000005);Hefei Municipal Development and Reform Commission.

摘　　要：Colchicine is an ancient herbal drug derived from Colchicum autumnale.It was first used to treat familial Mediterranean fever and gout.Based on its unique efficacy as an anti-inflammatory agent,colchicine has been used in the therapy of cardiovascular diseases including coronary artery disease,atherosclerosis,recurrent pericarditis,vascular restenosis,heart failure,and myocardial infarction.More recently,colchicine has also shown therapeutic efficacy in alleviating cardiovascular complications of COVID-19.COLCOT and LoDoCo2 are two milestone clinical trials that confirm the curative effect of long-term administration of colchicine in reducing the incidence of cardiovascular events in patients with coronary artery disease.There is growing interest in studying the anti-inflammatory mechanisms of colchicine.The anti-inflammatory action of colchicine is mediated mainly through inhibiting the assembly of microtubules.At the cellular level,colchicine inhibits the following:(1)endothelial cell dysfunction and inflammation;(2)smooth muscle cell proliferation and migration;(3)macrophage chemotaxis,migration,and adhesion;(4)platelet activation.At the molecular level,colchicine reduces proinflammatory cytokine release and inhibits NF-κB signaling and NLRP3 inflammasome activation.In this review,we summarize the current clinical trials with proven curative effect of colchicine in treating cardiovascular diseases.We also systematically discuss the mechanisms of colchicine action in cardiovascular therapeutics.Altogether,colchicine,a bioactive constituent from an ancient medicinal herb,exerts unique anti-inflammatory effects and prominent cardiovascular actions,and will charter a new page in cardiovascular medicine.

关 键 词：COLCHICINE anti-inflammatory drug cardiovascular diseases coronary artery disease atherosclerosis recurrent pericarditis RESTENOSIS heart failure myocardial infarction cardiovascular complications of COVID-19 MICROTUBULES NF-κB NLRP3 inflammas 

分 类 号：R54[医药卫生—心血管疾病]