URICASE

作品数：7被引量：18H指数：2
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相关机构：中国药科大学四川大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》《American Journal of Analytical Chemistry》《Acta Pharmaceutica Sinica B》更多>>
相关基金：国家自然科学基金王宽诚敎育基金更多>>
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Ce-UiO-66 nanozymes with charge-regulated uricase-like activity for enzyme/reagent-free detection of uric acid
《Nano Research》2025年第2期675-686,共12页Zhixiong Guo Da Chen Wei Gao Yongquan Qu Zhimin Tian 
This work was supported by the National Key Research and Development Program of China(No.2021YFB3500904);the National Natural Science Foundation of China(No.22475173);the Key Research and Development Program of Shaanxi(No.2024SF-YBXM-439);Authors also acknowledge the support from Fundamental Research Funds for the Central Universities(No.D5000210635).
Designing highly performed uricase-like nanozymes through enzymatic-like colorimetric analysis system is of vital significance for the quantitative detection of uric acid(UA).Herein,series of Ce-UiO-66 nanozymes with ...
关键词：Ce-UiO-66 uricase-like nanozyme colorimetric uric acid analysis enzyme/reagent-free detection smartphone 
Commentary:Gut microbiota reduce the risk of hyperuricemia and gout in the human body被引量：1
《Acta Pharmaceutica Sinica B》2024年第1期433-435,共3页Lin Wang Jianping Ye 
This study is supported by a project(32271220)from the Natural Science Foundation of China to Jianping Ye.
Gout,a prevalent and painful metabolic disease often associated with obesity and aging,is caused by the deposition of urate crystals in joints,bones,or soft tissues1.Urate is an intermediate metabolite within the puri...
关键词：Uric acid GOUT MICROBIOTA GUT URICASE 
Rapidly separating dissolving microneedles with sustained-release colchicine and stabilized uricase for simplified long-term gout management被引量：2
《Acta Pharmaceutica Sinica B》2023年第8期3454-3470,共17页Yao Yang Zimu Li Ping Huang Jiachan Lin Jinyuan Li Kexin Shi Jiahui Lin Jingwen Hu Zhuoxian Zhao Yongkang Yu Hongzhong Chen Xiaowei Zeng Lin Mei 
the financial support from the National Natural Science Foundation(NOs.32071342,and 82272154,China);Guangdong Special Support Program(NO.2019TQ05Y209,China);the Natural Science Foundation of Guangdong Province(NO.2023A1515012015,China);Tianjin Science Fund for Distinguished Young Scholars(NO.22JCJQJC00120,China);Natural Science Foundation of Tianjin(The Basic Research Cooperation Special Foundation of Beijing-Tianjin-Hebei Region,NO.22JCZXJC00060,China);the Fundamental Research Funds for the Central Universities(NO.2021-RC310-005,China);Technology&Innovation Commission of Shenzhen Municipality(NOs.JCYJ20220818102810023,JCYJ20190807153601667,and JCYJ20210324124402006,China);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(NOs.2021-I2M-1e058,and 2022-I2M-2-003,China)。
Despite growing prevalence and incidence,the management of gout remains suboptimal.The intermittent nature of the gout makes the long-term urate-lowering therapy(ULT)particularly important for gout management.However,...
关键词：MICRONEEDLES COLCHICINE SUSTAINED-RELEASE URICASE Liposome Transdermal administration Gout management Long-term urate-lowering therapy 
Preparation of New Uric Acid Sensors Based on Iodide Selective Electrode
《American Journal of Analytical Chemistry》2020年第5期205-212,共8页Sukru Kalayci 
the Gazi University research fund for the financial support of this research.
An electrode for uric acid has been prepared by using an iodide selective electrode with the uricase enzyme. The iodide selective electrode used was prepared from 10% TDMAI and PVC according to our previous study. The...
关键词：Uric Acid Electrode URICASE ENZYME Iodide Selective Electrode Uric Acid in Blood 
Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy被引量：2
《Acta Pharmacologica Sinica》2019年第10期1364-1372,共9页Yi Shi Ting Wang X.Edward Zhou Qiu-feng Liu Yi Jiang H.Eric Xu 
This work was supported by the National Natural Science Foundation of China(31770796 to YJ);the Strategic Priority Research Program of CAS(XDB08020303 to HEX);the National Science and Technology Major Project(2018ZX09711002-002-002 to YJ);the K.C.Wong Education Foundation(to YJ).
Arthrobacter globiformis Uricase(AgUricase)is a homotetrameric uricase with the potential for therapeutic use in treating hyperuricemia-related diseases.To achieve sufficient therapeutic effects,it is essential for th...
关键词：URICASE thermostability DISULFIDE cross-linking CRYSTAL structure 
Science Letters:Evaluation of a kinetic uricase method for serum uric acid assay by predicting background absorbance of uricase reaction solution with an integrated method被引量：12
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2006年第6期497-502,共6页LIAO Fei ZHAO Yun-sheng ZHAO Li-na TAO Jia ZHU Xiao-yun LIU Lan 
Project (No. 30200266) supported by the National Natural Science Foundation of China
A patented kinetic uricase method was evaluated for serum uric acid assay. Initial absorbance of the reaction mixture before uricase action （A0） was obtained by correcting the absorbance at 293 nm measured before th...
关键词：Background absorbance Bland-Altman analysis Kinetic uricase method Reaction curve fitting Serum uric acid assay 
Kinetic method for enzymatic analysis by predicting background with uricase reaction as model被引量：7
《Journal of Medical Colleges of PLA(China)》2005年第6期338-344,共7页廖飞 赵运胜 赵利娜 陶佳 朱小云 王咏梅 左渝平 
SupportedbytheNationalNaturalScienceFoundationofChina(No.30200266)
Objective：To investigate the reliability for kinetic assay of substance with background predicted by the integrated method using uricase reaction as model. Methods： Absorbance before uricase action （Δ0） was estim...
关键词：kinetic method enzymatic methods PREDICTION reaction curve fitting URICASE 
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