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AstragalosideⅣAlleviates Podocyte Injury in Diabetic Nephropathy through Regulating IRE-1α/NF-κB/NLRP3 Pathway
《Chinese Journal of Integrative Medicine》2025年第5期422-433,共12页SUN Da-lin GUO Zi-yi LIU Wen-yuan ZHANG Lin ZHANG Zi-yuan HU Ya-ling LI Su-fen ZHANG Ming-yu ZHANG Guang WANG Jin-jing FANG Jing-ai 
Supported by the International Cooperation Project of Department of Science and Technology of Shanxi Province(No.201903D421057);the Youth Fund Project of Department of Science and Technology of Shanxi Province(No.201901D211485)。
Objective:To investigate the effects of astragalosideⅣ(AS-Ⅳ)on podocyte injury of diabetic nephropathy(DN)and reveal its potential mechanism.Methods:In in vitro experiment,podocytes were divided into 4 groups,normal...
关键词:diabetic nephropathy astragalosideⅣ PODOCYTE inositol-requiring enzyme 1α/nuclear factor kappa Bp65/NLR family pyrin domain containing 3 pathway 
Rational construction of enzyme-like stereoselective magnetic chiral nanozymes
《Nano Research》2025年第4期316-324,共9页Xuan Chen Shenli Wang Xiaoxiao Zhang Stefanos Mourdikoudis Chengxiao Song Leung Siu Lun Juan Xie Wing-leung Wong Jorge Perez-Juste Isabel Pastoriza-Santos Kwok-Yin Wong Guangchao Zheng 
the National Natural Science Foundation of China(Nos.22271257,32202063,and 21902148);Natural Science Foundation of Henan(No.232300421096);the National Key R&D Program of China(No.2024YFE0105200);Start-up Research Fundation of Henan University of Technology(No.2021BS053);the Innovation and Technology Commission of Hong Kong,The Hong Kong Polytechnic University;the support from MICIU/AEI/10.13039/501100011033;ERDF/EU(No.PID2022-138724NB-I00);the Xunta de Galicia/ERDF(No.GRC ED431C 2020/09).
Recent studies support that magnetic chiral nanozymes,integrating the features of chirality,magnetism,and enzyme-like catalysis,provide new insights into the synthetic methodologies and applications of chiral nanozyme...
关键词:chiral cobalt superstructures chirality origin solvent effect magnetic circular dichroism enzyme-like stereoselectivity 
Enzyme-like adaptive Fe-oxo-Co motifs boost oxygen reduction reaction for efficient Zn-air batteries
《Nano Research》2025年第4期134-143,共10页Tian Xia Jiawei Wan Xu Zhou Yilei He Fengmei Su Bifa Ji Yongping Zheng Dan Wang Ranbo Yu 
the National Key Research and Development Program of China(Nos.2022YFA1204500 and 2022YFA1204502);the National Natural Science Foundation of China(Nos.22293043,51932001,52372170,and 92163209);the Beijing-Tianjin-Hebei Basic Research Cooperation Special Project(No.B2024204027);IPE Project for Frontier Basic Research(No.QYJC-2023-08).
Enzyme-like metal atomic site catalysts are promising alternatives of platinum group metals for oxygen reduction reaction(ORR)in fuel cell application.The local coordination structure at metal atomic sites plays a dom...
关键词:ADAPTIVE oxygen reduction reaction dual atomic site Zn-air battery 
Cationic carbon dots:A novel class of mimetic enzymes
《Nano Research》2025年第4期493-515,共23页Xin Wu Zhuang Tong Yunliang Liu Yi Yang Yaxi Li Yuanyuan Cheng Jingwen Yu Naiyun Liu Chanyuan Jin Haitao Li 
supported by the National Natural Science Foundation of China(Nos.52072152,and 51802126);the Jiangsu University Jinshan Professor Fund;the Jiangsu Specially-Appointed Professor Fund;Open Fund from Guangxi Key Laboratory of Electrochemical Energy Materials,Zhenjiang“Jinshan Talents”Project 2021;China PostDoctoral Science Foundation(No.2022M721372);“Doctor of Entrepreneurship and Innovation”in Jiangsu Province(No.JSSCBS20221197);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(Nos.KYCX22_3645 and KYCX24_3964).
Natural enzymes are highly efficient catalysts with strong substrate specificity,making them ideal for biomedical applications.However,they often face issues such as variability,high costs,challenging preparation proc...
关键词:cationic carbon dots enzyme-like CATALYSIS applications NANOMATERIALS 
Peptide bridging for cofactor channeling in fusion enzyme lowers cofactor input by two orders of magnitude
《Chinese Journal of Catalysis》2025年第4期390-403,共14页Zehui Guo Yan Sun 
国家重点研发计划(2018YFA0900702).
Biocatalysis with nicotinamide adenine dinucleotide phosphate(NADP)-dependent oxidoreductases faces a challenge in improving the efficiency of the costly cofactor utilization.Although enzyme fusion can offer cofactor ...
关键词:Peptide bridge Fusion enzyme NADP(H)-dependent oxidoreductases Cofactor channeling Cofactor regeneration 
Extraction of high activity bacterial urease and its application to biomineralization of soil
《Journal of Rock Mechanics and Geotechnical Engineering》2025年第3期1847-1861,共15页Hanjiang Lai Yiwei Chen Mingjuan Cui Junjie Zheng Zhibo Chen 
the National Natural Science Foundation of China(NSFC)(Grant Nos.52108307 and 52178319);the Natural Science Foundation of Fujian Province,China(Grant No.2022J05020).
Biomineralization based on bacterial enzyme induced carbonate precipitation(BEICP)process is a promising alternative to cement-based ground treatment technology.The bacterial urease used in BEICP process is usually ul...
关键词:BIOMINERALIZATION Bacterial enzyme induced carbonate precipitation(BEICP) Urease extraction Ultrasound Soil improvement 
An enzyme-gated bioorthogonal catalytic nanoreactor for tumor specific prodrug activation
《Nano Research》2025年第2期557-570,共14页Yuheng Guo Fang Jiang Xiaohui Zhu Wen He Sijie Song Xuecen Shou Mengnan Wu Ting Wu Tingjing Huang Zhi Ye Xuyang Wang Zhitong Chen Yu He Yuhang Yao Zhaowei Chen Huanghao Yang 
This work was funded by the National Key Research and Development Program of China(No.2020YFA0210800,H.H.Y.);the Major Project of Science and Technology of Fujian Province(No.2020HZ06006,H.H.Y.);the National Natural Science Foundation of China(Nos.22421002,22027805,and 22334004,H.H.Y.,Nos.22107019,and 22277011,Z.W.C.,No.22404025,Y.H.Y.);the Research project of General Administration of Customs of PRC(No.2024HK008,X.H.Z.).
Bioorthogonal catalysis mediated by abiotic transition metal catalysts(TMCs)is emerging as a momentum-gathering strategy for in situ generation of therapeutics.However,the unpredictable leakage and deposition of TMCs ...
关键词:bioorthogonal catalysis PRODRUGS enzyme-gated catalyst immobilization cancer therapy 
Ce-UiO-66 nanozymes with charge-regulated uricase-like activity for enzyme/reagent-free detection of uric acid
《Nano Research》2025年第2期675-686,共12页Zhixiong Guo Da Chen Wei Gao Yongquan Qu Zhimin Tian 
This work was supported by the National Key Research and Development Program of China(No.2021YFB3500904);the National Natural Science Foundation of China(No.22475173);the Key Research and Development Program of Shaanxi(No.2024SF-YBXM-439);Authors also acknowledge the support from Fundamental Research Funds for the Central Universities(No.D5000210635).
Designing highly performed uricase-like nanozymes through enzymatic-like colorimetric analysis system is of vital significance for the quantitative detection of uric acid(UA).Herein,series of Ce-UiO-66 nanozymes with ...
关键词:Ce-UiO-66 uricase-like nanozyme colorimetric uric acid analysis enzyme/reagent-free detection smartphone 
Enhanced cofactor recycling and accelerated reaction rate via liquid-liquid phase separation in dual-enzyme condensates
《Chinese Journal of Catalysis》2025年第2期135-148,共14页Jiaxu Liu Jiaxin Chen Xiaoyan Zhang Daidi Fan Yunpeng Bai 
国家重点研发计划(2023YFA0913600);国家自然科学基金(22378120,22078096)。
Enzyme catalysis is a promising way to produce chiral products in a green and sustainable way.However,the high cost of cofactors and their relatively low recycling efficiency hinder the widespread application of enzym...
关键词:Cofactor recycling CONDENSATE Proximity effect Intrinsically disordered region Enzyme catalysis 
Chiral inorganic nanocatalysts for electrochemical and enzyme⁃mimicked biosensing
《无机化学学报》2025年第1期59-78,共20页LIU Chuang SUN Lichao ZHANG Qingfeng 
国家自然科学基金(No.22174104,22472119,22405195);江苏省自然科学基金(No.BK20240448)资助。
In recent years,chiral inorganic nanomaterials have become promising candidates for applications in sensing,catalysis,biomedicine,and photonics.Plasmonic nanomaterials with an intrinsic chiral structure exhibit intrig...
关键词:chiral inorganic nanomaterial chiral plasmonic electrochemical biosensing enzyme‑mimicked biosensing asymmetric nanocatalysis 
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