PODOCYTE

作品数：67被引量：357H指数：11
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相关机构：浙江省人民医院昆明医科大学淮安市第二人民医院江苏省人民医院更多>>
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AstragalosideⅣAlleviates Podocyte Injury in Diabetic Nephropathy through Regulating IRE-1α/NF-κB/NLRP3 Pathway
《Chinese Journal of Integrative Medicine》2025年第5期422-433,共12页SUN Da-lin GUO Zi-yi LIU Wen-yuan ZHANG Lin ZHANG Zi-yuan HU Ya-ling LI Su-fen ZHANG Ming-yu ZHANG Guang WANG Jin-jing FANG Jing-ai 
Supported by the International Cooperation Project of Department of Science and Technology of Shanxi Province(No.201903D421057);the Youth Fund Project of Department of Science and Technology of Shanxi Province(No.201901D211485)。
Objective:To investigate the effects of astragalosideⅣ(AS-Ⅳ)on podocyte injury of diabetic nephropathy(DN)and reveal its potential mechanism.Methods:In in vitro experiment,podocytes were divided into 4 groups,normal...
关键词：diabetic nephropathy astragalosideⅣ PODOCYTE inositol-requiring enzyme 1α/nuclear factor kappa Bp65/NLR family pyrin domain containing 3 pathway 
mTOR pathway:A key player in diabetic nephropathy progression and therapeutic targets
《Genes & Diseases》2025年第2期202-215,共14页Jingxuan Shi Xinze Liu Yuanyuan Jiao Jingwei Tian Jiaqi An Guming Zou Li Zhuo 
supported by the Elite Medical Professionals Project of China-Japan Friendship Hospital (No.ZRJY2021-BJ07);the National High Level Hospital Clinical Research Funding (China) (No.2023-NHLHCRF-PY-07);the National Natural Science Foundation of China (No.81870495).
Diabetic nephropathy is a prevalent complication of diabetes and stands as the pri-mary contributor to end-stage renal disease.The global prevalence of diabetic nephropathy is on the rise,however,due to its intricate ...
关键词：BIBLIOMETRICS Diabetic nephropathy Glomerular endothelial cell Immune cell Mesangial cell mTOR PODOCYTE Renal tubular epithelial cell 
Diosgenin inhibited podocyte pyroptosis in diabetic kidney disease by regulating the Nrf2/NLRP3 pathway
《BIOCELL》2024年第10期1503-1516,共14页YU TANG WENXIAO HU YAJUN PENG XIANGDONG LING 
General Funded Project of Hunan Provincial Health Commission(No.202203054238);Hunan University of Chinese Medicine Campus Joint Fund Project(Nos.2023XYLH022,2023XYLH028);Project of Key Specialties of Chinese Medicine in Hunan Province(axm-sbk-2023001,cxm-nfmnk-2023001).
Background:Podocyte injury is crucial in diabetic kidney disease(DKD)progression,and the mechanism remains unclear.The previous studies indicated Diosgenin played a key role in inhibiting podocyte injury progression.H...
关键词：DIOSGENIN NRF2 NLRP3 Diabetic kidney disease PYROPTOSIS 
Linggui Zhugan Decoction Improves High Glucose-Induced Autophagy in Podocytes
《Chinese Medical Sciences Journal》2024年第3期193-202,共10页Yuan-Yuan Wang Jian Qin Ru-Lan Zhang Min-Ji Yu Ming-Hua Jin 
supported by Guangdong Bureau of Traditional Chinese Medicine (20211082)
Objective To explore the influence of Linggui Zhugan Decoction(LGZGD) on high glucose induced podocyte autophagy.Methods LGZGD containing serum was prepared by intragastric administation of 4.2 g/kg(low dose), 8.4 g/k...
关键词：diabetic nephropathy PODOCYTE Linggui Zhugan decoction APOPTOSIS AUTOPHAGY 
Foodborne toxin Aflatoxin B_(1)induced glomerular podocyte inflammation through proteolysis of RelA,downregulation of miR-9 and CXCR4/TXNIP/NLRP3 pathway
《Food Science and Human Wellness》2024年第4期2289-2309,共21页Jie Zhang Shuang Yang Baocai Xu Zihui Qin Xinyi Guo Ben Wei Qinghua Wu Kamil Kuca Tushuai Li Wenda Wu 
funded by Suzhou Science and Technology Council(SNG201907);Universities Natural Science Foundation of Jiangsu Province(20KJB330002);General Program of China Postdoctoral Science Foundation(2022M711369);the Startup Funding of Soochow University,Jiangsu Province-Suzhou Science and Technology Planning Project(SL T201917);National Natural Science Foundation of China(32172922,31972741);Natural Science Foundation of Jiangsu Province of China(BK20211216,BK20221091);the Startup Funding of Hefei University of Technology(1302003712022058);China-CEEC Joint University Education Project(202010);the Excellence Project PrF UHK(2217/2022-2023)。
Aflatoxin B_(1)(AFB_(1))is a naturally-occurring mycotoxin and recognized as the most toxic foodborne toxin,particularly causing damages to kidney.Glomerular podocytes are terminally differentiated epithelial cells.AF...
关键词：Aflatoxin B_(1) Podocyte inflammation miRNA-9 Chemokine(C-X-C motif)receptor 4 RelA ubiquitin-dependent degradation 
Long noncoding RNA protein-disulfide isomerase-associated 3 regulated high glucose-induced podocyte apoptosis in diabetic nephropathy through targeting miR-139-3p
《World Journal of Diabetes》2024年第2期260-274,共15页Yin-Xi He Ting Wang Wen-Xian Li Yan-Xia Chen 
Supported by the Natural Science Funds for Young Scholar of Hebei,China,No.H2020206108;the Subject of Health Commission of Hebei,China,No.20210151.
BACKGROUND Podocyte apoptosis plays a vital role in proteinuria pathogenesis in diabetic nephropathy(DN).The regulatory relationship between long noncoding RNAs(lncRNAs)and podocyte apoptosis has recently become anoth...
关键词：Long noncoding RNAs Diabetic nephropathy Podocyte apoptosis Endoplasmic reticulum stress Competing endogenous RNA 
Changes in macrophage infiltration and podocyte injury in lupus nephritis patients with repeated renal biopsy: Report of three cases
《World Journal of Clinical Cases》2024年第1期188-195,共8页Shi-Yuan Liu Hao Chen Li-Jia He Chun-Kai Huang Pu Wang Zhang-Ru Rui Jue Wu Yang Yuan Yue Zhang Wen-Ju Wang Xiao-Dan Wang 
Supported by National Natural Science Foundation of China,No.81960136;the Science and Technology Department of Yunnan Province,No.202101AT070243.
BACKGROUND In this study,we retrospectively analysed macrophage infiltration and podocyte injury in three patients with diffuse proliferative lupus nephritis(LN)who un-derwent repeated renal biopsy.CASE SUMMARY Clinic...
关键词：Lupus nephritis MACROPHAGE PODOCYTE Repeat renal biopsy Thrombotic microangiopathy Case report 
Podocyte injury and death:New insights into lupus nephritis pathogenesis and therapy被引量：1
《Rheumatology & Autoimmunity》2023年第4期193-204,共12页Xiaolei Shi Zhipeng Wang Ruihan Tang Wei Chen 
Key Laboratory of National Health Commission,and Key Laboratory of Nephrology,Guangdong Province,Guangzhou,China,Grant/Award Numbers:2002B60118,2020B1212060028;National Natural Science Foundation of China,Grant/Award Numbers:81970599,82170737。
Lupus nephritis(LN),an immune complex-mediated glomerulonephritis,is one of the most severe complications of systemic lupus erythematosus.Current therapeutic regimens for LN mainly involve nonspecific immunosuppressan...
关键词：cell death INJURY lupus nephritis PODOCYTE treatment 
Emodin Ameliorates High Glucose-Induced Podocyte Apoptosis via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway被引量：3
《Chinese Journal of Integrative Medicine》2023年第9期801-808,共8页LIU Hong CHEN Wei-dong HU Yang-lin YANG Wen-qiang HU Tao-tao WANG Huan-lan ZHANG Yan-min 
Supported by the Chinese Medicine Research Project of Hubei Provincial Health Commission(No.ZY2019Q024);Scientific Research Project of Wuhan Municipal Health Commission(No.WX20B11);Scientific Research Project of Wuhan Municipal Health Commission(No.WZ20C01)。
Objective To investigate the effect of emodin on high glucose(HG)-induced podocyte apoptosis and whether the potential anti-apoptotic mechanism of emodin is related to induction of adenosine-monophosphate-activated pr...
关键词：EMODIN diabetic nephropathy AUTOPHAGY podocyte apoptosis adenosine-monophosphate-activated protein kinase/mammalian target of rapamycin signaling pathways 
Exosomal miR-30a-5p targets NLRP3 to suppress podocyte pyroptosis in diabetic nephropathy
《BIOCELL》2023年第9期1995-2008,共14页WEI LU KAN GUO DIANMEI XI ZHAOXIA XIA 
Background:Mesenchymal stem cell(MSC)-derived exosomes are closely related to pyroptosis in diabetic nephropathy(DN).This study aimed to explore the protective effect of exosomal miR-30a-5p on podocyte pyroptosis in D...
关键词：Diabetic nephropathy PODOCYTE PYROPTOSIS Exosomal miR-30a-5p NLRP3 
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