Changes in macrophage infiltration and podocyte injury in lupus nephritis patients with repeated renal biopsy: Report of three cases  

作　　者：Shi-Yuan Liu Hao Chen Li-Jia He Chun-Kai Huang Pu Wang Zhang-Ru Rui Jue Wu Yang Yuan Yue Zhang Wen-Ju Wang Xiao-Dan Wang 

机构地区：[1]Central Laboratory,Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province,Yan'an Hospital Affiliated to Kunming Medical University,Kunming 650051,Yunnan Province,China [2]Department of Nephropathy,Yan'an Hospital Affiliated to Kunming Medical University,Kunming 650051,Yunnan Province,China

出　　处：《World Journal of Clinical Cases》2024年第1期188-195,共8页世界临床病例杂志

基　　金：Supported by National Natural Science Foundation of China,No.81960136;the Science and Technology Department of Yunnan Province,No.202101AT070243.

摘　　要：BACKGROUND In this study,we retrospectively analysed macrophage infiltration and podocyte injury in three patients with diffuse proliferative lupus nephritis(LN)who un-derwent repeated renal biopsy.CASE SUMMARY Clinical data of three diffuse proliferative LN patients with different pathological characteristics(case 1 was LN IV-G(A),case 2 was LN IV-G(A)+V,and case 3 was LN IV-G(A)+thrombotic microangiopathy)were reviewed.All patients underwent repeated renal biopsies 6 mo later,and renal biopsy specimens were studied.Macrophage infiltration was assessed by CD68 expression detected by immunohistochemical staining,and an immunofluorescence assay was used to detect podocin expression to assess podocyte damage.After treatment,Case 1 changed to LN III-(A),Case 2 remained as type V LN lesions,and Case 3,which changed to LN IV-S(A),had the worst prognosis.We observed reduced macro-phage infiltration after therapy.However,two of the patients with active lesions after treatment still showed macrophage infiltration in the renal interstitium.Before treatment,the three patients showed discontinuous expression of podocin.Notably,the integrity of podocin was restored after treatment in Case 1.CONCLUSION It may be possible to reverse podocyte damage and decrease the infiltrating ma-crophages in LN patients through effective treatment.

关 键 词：Lupus nephritis MACROPHAGE PODOCYTE Repeat renal biopsy Thrombotic microangiopathy Case report 

分 类 号：R593.242[医药卫生—内科学]