DIOSGENIN

作品数：27被引量：102H指数：6
导出分析报告
相关领域：医药卫生更多>>
相关作者：王刚孙作厘杨健孙启玲苏建更多>>
相关机构：首都医科大学附属北京安定医院四川大学湖北师范学院福建医科大学更多>>
相关期刊：《Journal of Hainan Medical University》《Asian Pacific Journal of Tropical Biomedicine》《Natural Products and Bioprospecting》《Chinese Journal of Chemical Engineering》更多>>
相关基金：国家自然科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Diosgenin inhibited podocyte pyroptosis in diabetic kidney disease by regulating the Nrf2/NLRP3 pathway
《BIOCELL》2024年第10期1503-1516,共14页YU TANG WENXIAO HU YAJUN PENG XIANGDONG LING 
General Funded Project of Hunan Provincial Health Commission(No.202203054238);Hunan University of Chinese Medicine Campus Joint Fund Project(Nos.2023XYLH022,2023XYLH028);Project of Key Specialties of Chinese Medicine in Hunan Province(axm-sbk-2023001,cxm-nfmnk-2023001).
Background:Podocyte injury is crucial in diabetic kidney disease(DKD)progression,and the mechanism remains unclear.The previous studies indicated Diosgenin played a key role in inhibiting podocyte injury progression.H...
关键词：DIOSGENIN NRF2 NLRP3 Diabetic kidney disease PYROPTOSIS 
Adaptogenic action of diosgenin againsts chronic unpredictable mild stress-induced neuroimmune dysfunction of HPA axis reverses psychiatric behavior in mice
《Clinical Traditional Medicine and Pharmacology》2024年第3期22-34,共13页Benneth Ben-Azu Emmanuel O.Chidebe Pere-Ebi Y.Toloyai Olajide S.Annafi Benjamin Oritsemuelebi Jerome Asiwe Goodies E.Moke Abayomi M.Ajayi Nwogueze B.Chukwuebuka Jackson E.Onuelu Chidiebere W.Utomi Uyi F.Iregbeyen David O.Raheem 
Background:Stressful life experiences are associated with neurobehavioral abnormalities,such as anxiogenic-related depression and cognitive decline.Reportedly,adaptogens are well known to modulate stress-related re-sp...
关键词：DIOSGENIN Stress ANXIETY DEPRESSION Adaptogens 
Network pharmacology and molecular docking analysis reveal insights into the molecular mechanism of Gualou Qumai Wan in clear cell renal cell carcinoma
《TMR Modern Herbal Medicine》2024年第2期11-18,共8页Zhi-Qiang Wang Zhen-Yu Mu Bo Yang Tao Wang Zhi-Yong Su Shan-Chun Guo Jiang-Xia Yin 
supported by Weifang Health Commission Traditional Chinese Medicine Research Project Plan(WFZYY2023-1-004).
Background:To initially clarify the potential therapeutic targets and pharmacological mechanism regarding Gualou Qumai Wan(GQW),a kind of traditional Chinese medicine(TCM),in clear cell renal cell carcinoma(ccRCC)by v...
关键词：Gualou Qumai Wan AKT1 PI3K-Akt signaling pathway network pharmacology DIOSGENIN clear cell renal cell carcinoma 
Bioinformatics and network pharmacology identify the therapeutic role and potential targets of diosgenin in Alzheimer disease and COVID-19
《Journal of Hainan Medical University》2024年第1期39-49,共11页ZHANG Hua-xiong ZHANG Ming-hui LI Hong-yan 
Research and Development and Industrialization Demonstration of Xinjiang Special Medicinal Materials,Antiinfective Drugs and Disinfection Products-Construction of Xinjiang Special Resource Antiinfective Drug Research and Development Platform(No.2021A03002-4)。
Objective: This study aims to investigate the potential targets of diosgenin for the treatment of Alzheimer's disease (AD) and Coronavirus Disease 2019 (COVID-19) through the utilization of bioinformatics, network pha...
关键词：BIOINFORMATICS Network pharmacology DIOSGENIN Alzheimer's disease COVID-19 
Anticancer Activity of Diosgenin and Its Molecular Mechanism被引量：1
《Chinese Journal of Integrative Medicine》2023年第8期738-749,共12页REN Qun-li WANG Qian ZHANG Xin-qun WANG Miao HU Huan TANG Jun-jie YANG Xiong-tong RAN Ying-hui LIU Huan-huan SONG Zhi-xing LIU Jian-guo LI Xiao-lan 
the National Natural Science Foundation of China(No.31860076);Outstanding Young Talent Project of Zunyi Medical University(No.17zy-002);Technology Support Program of Zunyi(No.ZSKH-HZ-ZI-2020-88);Science and Technology Project of Zunyi[ZSKH-HZ(2020)No.60/55];Special Project of Zunyi Medical University for Academic New Talents[No.QKHPT(2018)5772-067/062];Guizhou Provincial Chinese Medicine Administration Project(No.QZYY-2019-064)。
Diosgenin, a steroidal sapogenin, obtained from Trigonella foenum-graecum, Dioscorea, and Rhizoma polgonati, has shown high potential and interest in the treatment of various cancers, such as oral squamous cell carcin...
关键词：DIOSGENIN steroidal sapogenin ANTICANCER molecular mechanism biological activity 
Establishment of Quality Standard for Freeze-dried Tablets of Polygonatum sibiricum and Study on Anti-tumor Activity of Diosgenin
《Medicinal Plant》2022年第5期21-25,30,共6页Jianguang ZENG Zhengyong YU Hao LI Yusheng XU 
Supported by Key S&T Special Projects of Yunnan Department of Science and Technology(2018F004);National Natural Science Foundation of China(31900300)。
[Objectives]The paper was to establish the quality standard for freeze-dried tablets of Polygonatum sibiricum and to explore the antitumor activity of its extract diosgenin.[Methods]Taking freeze-dried powder samples ...
关键词：Polygonatum sibiricum HPLC DIOSGENIN Content determination Quality standard Anti-tumor activity 
The origin and evolution of the diosgenin biosynthetic pathway in yam被引量：4
《Plant Communications》2021年第1期45-53,共9页Jian Cheng Jing Chen Xiaonan Liu Xiangchen Li Weixiong Zhang Zhubo Dai Lina Lu Xiang Zhou Jing Cai Xueli Zhang Huifeng Jiang Yanhe Ma 
supported by grants from the National Key R&D Program of China(no.2019YFA0905700 and 2019YFA0905300);the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(TSBICIPKJGG-002);the Key Research Program of the Chinese Academy of Sciences(KFZD-SW-215);the Tianjin Science Fund for Distinguished Young Scholars(18JCJQJC48300);the National Science and Technology Major Project(2018ZX09711001-006-003);the Major Science and Technique Programs in Yunnan Province(2019ZF011);the National Science Fund for Excellent Young Scholars(31922047).
Diosgenin,mainly produced by Dioscorea species,is a traditional precursor of most hormonal drugs in the pharmaceutical industry.The mechanisms that underlie the origin and evolution of diosgenin biosynthesis in plants...
关键词：metabolic engineering genomic evolution DIOSGENIN synthetic biology 
Designing and optimizing a parallel neural network model for predicting the solubility of diosgenin in n-alkanols
《Chinese Journal of Chemical Engineering》2021年第1期288-294,共7页Huichao Lv Dayong Tian 
supported by the Science and Technology Plan Project of Henan Province (No. 192102310232)。
Accurate estimation of the solubility of a chemical compound is an important issue for many industrial proce sses.To overcome the defects of some thermodynamic models and simple correlations,a parallel neural network(...
关键词：SOLUBILITY DIOSGENIN Parallel neural network model NRTL model 
Crystal Structures, Stability, and Solubility Evaluation of a 2:1 Diosgenin-Piperazine Cocrystal被引量：7
《Natural Products and Bioprospecting》2020年第4期261-267,共7页Ningbo Gong Hongmei Yu Ying Wang Cheng Xing Kun Hu Guanhua Du Yang Lu 
support by National Key research and development Program of China(Grant No.2016YFC1000900);CAMS Innovation Found for Medical Sciences(Grant No.2017-I2M-1-010);Construction and application of technology integration system for efficient identification of natural/effective active small molecules(Grant No.2018ZX09711001-001);National Science and Technology Major Project of China(Grant No.2018ZX09711001-010).
A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized.The solid form was prepared by liquid assisted grinding,slurry and crystallization methods.The cocrystal was characterized by ...
关键词：DIOSGENIN PIPERAZINE COCRYSTAL Characterization SOLUBILITY 
Novel diosgenin derivative attenuates hippocampal neurogenesis and cognition impairment through blocking microglial activation underlying NF-κB and JNK MAPK signaling in LPS induced-adult mice
《中国药理学与毒理学杂志》2019年第6期476-477,共2页CAI Bang-rong 
OBJECTIVE Diosgenin(DG), a naturally occurring steroidal saponin, has been reported to offer a variety ofpharmacological activities including anti-diabetic and anti-tumor activity, anti-inflammatory and anti-AD. Howev...
关键词：DIOSGENIN NEUROGENESIS neural stem cells PRO-INFLAMMATORY CYTOKINES 
全选清除导出
共3页<123>
检索报告 对象比较 聚类工具 使用帮助 返回顶部