Crystal Structures, Stability, and Solubility Evaluation of a 2:1 Diosgenin-Piperazine Cocrystal  

作　　者：Ningbo Gong Hongmei Yu Ying Wang Cheng Xing Kun Hu Guanhua Du Yang Lu 

机构地区：[1]Beijing Key Laboratory of Polymorphic Drugs,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China [2]Beijing City Key Laboratory of Drug Target Identification and Drug Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出　　处：《Natural Products and Bioprospecting》2020年第4期261-267,共7页应用天然产物（英文）

基　　金：support by National Key research and development Program of China(Grant No.2016YFC1000900);CAMS Innovation Found for Medical Sciences(Grant No.2017-I2M-1-010);Construction and application of technology integration system for efficient identification of natural/effective active small molecules(Grant No.2018ZX09711001-001);National Science and Technology Major Project of China(Grant No.2018ZX09711001-010).

摘　　要：A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized.The solid form was prepared by liquid assisted grinding,slurry and crystallization methods.The cocrystal was characterized by powder X-ray diffraction,differential scanning calorimetry,thermogravimetric analysis,Fourier transform infrared spectroscopy,and structure determined by single crystal X-ray diffraction,the hydrogen bonds formed into fish bone structure along the[010]direction and all the molecules packed into 3D layer structure along a axis.After formation of cocrystal,the solubility of diosgenin was improved,and the solubility value in 0.2%SDS solution was approximately 1.5 times as large as that of the parent material.

关 键 词：DIOSGENIN PIPERAZINE COCRYSTAL Characterization SOLUBILITY 

分 类 号：O62[理学—有机化学]