COCRYSTAL

作品数：51被引量：58H指数：4
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相关领域：理学医药卫生更多>>
相关作者：苏晴更多>>
相关机构：中国药科大学更多>>
相关期刊：《Chemical Research in Chinese Universities》《Science China Materials》《Aggregate》《Transactions of Tianjin University》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划湖北省自然科学基金广西壮族自治区自然科学基金更多>>
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Cocrystal pleomorphism-inspired drug nanoassembly for pulmonary-endothelium targeting and pulmonary hypertension treatment
《Acta Pharmaceutica Sinica B》2025年第1期557-570,共14页Makhloufi Zoulikha Jiahui Zou Pei Yang Jun Wu Wei Wu Kun Hao Wei He 
supported by the National Natural Science Foundation of China(Nos.82073782 and 82241002);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(21KJA320003);the Scientific Research Project of Jiangsu Commission of Health(LKZ2023001,China);the Clinical Competence Improvement Project of Jiangsu Province Hospital(JSPH-MB-2022-13,China).
Endothelial dysfunction is one of the early triggers of vascular remodeling during pulmonary hypertension(PH)with complex predisposing mechanisms,mainly via an unbalanced generation of vasoactive factors,increased exp...
关键词：Pulmonary hypertension Inflammation Endothelial dysfunction ENDOTHELIN COCRYSTALS Nanorods BOSENTAN ANDROGRAPHOLIDE 
Epitaxially Growing 2D RGB Trichromatic Cocrystal Nanomeshes to Trigger Cross-Modulation White Light Emission
《Chinese Journal of Chemistry》2024年第24期3379-3386,共8页Wenyubin Luo Cheng Zhang Shan Yang Lei Ding Yang Li Yanqiu Sun Qichun Zhang 
supported from the National Natural Science Foundation of China(Grants Nos.22008164,62304148,and 52373300);the Natural Science Foundation of Jiangsu Province(Grants No.BK20230074);Research in Cutting-Edge Technology of Suzhou(Grants No.SYG202351).
Considering their oriented crystalline structure and high luminescent efficiency,the exploration of multi-component organic cocrystal systems with tunable supramolecular nanostructures and potential RGB light emission...
关键词：Organic cocrystal NANOMESH RGB trichromatic system Cross-modulation white light emission Competitive intermolecular interactions Organic optoelectronics Photoelectric performances 2D materials 
Organic cocrystals:From high-performance molecular materials to multi-functional applications
《Aggregate》2024年第6期67-92,共26页Yuqing Ding Yan Zhao Yunqi Liu 
Ministry of Science and Technology of the People’s Republic of China,Grant/Award Number:2022YFB3603804;Natural Science Foundation of Shanghai Municipality,Grant/Award Number:22ZR1407800。
Advancements in organic electronics are propelling the development of new material systems,where organic materials stand out for their unique benefits,including tunability and cost-effectiveness.Organic single crystal...
关键词：COCRYSTAL ELECTRONICS PHOTONICS photothermal conversion stimuli-responsive behaviors 
Cocrystal@protein-anchoring nanococktail for combinatorially treating multidrug-resistant cancer
《Acta Pharmaceutica Sinica B》2024年第10期4509-4525,共17页Jiahui Zou Xuyang Xing Chao Teng Qingling Zhao Wei He Xuri Wu Yuanzheng Xia 
supported by the National Natural Science Foundation of China(Nos.82073782 and 82241002,China);the Shanghai Science and Technology Committee(No.19430741500,China);National Key Research and Development Program of China(2018YFA0902000,China);the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine(zdsys-202103,China).
Multidrug resistance(MDR),the major mechanism by which various cancers develop specific resistance to therapeutic agents,has set up enormous obstacles to many forms of tumor chemotherapy.Traditional cocktail therapy a...
关键词：COCKTAIL MULTIDRUG-RESISTANT Co-delivery combined therapy Cytochrome C NANOCRYSTALS 
Organic stoichiometric cocrystals with a subtle balance of charge-transfer degree and molecular stacking towards high-efficiency NIR photothermal conversion
《Chinese Chemical Letters》2024年第10期180-186,共7页Jieqiong Xu Wenbin Chen Shengkai Li Qian Chen Tao Wang Yadong Shi Shengyong Deng Mingde Li Peifa Wei Zhuo Chen 
supported by the National Natural Science Foundation of China(Nos.22001006,22375002,22273057,22225401);the Anhui Provincial Natural Science Foundation(No.2308085Y10);the Open Project of Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Anhui University,Ministry of Education;The National Key Research and Development Program of China(Nos.2022YFC_(2)403500,2020YFA0210800);The Universities Joint Laboratory of Guangdong,Hong Kong and Macao(No.130/07422011);the Natural Science Foundation of Guangdong Province(No.2022A1515011661);the China Postdoctoral Science Foundation(Nos.2023M730760,2023M740010)。
Charge-transfer(CT)stoichiometric cocrystals are promising choice of organic materials for unveiling the structure-property relationship.However,due to the contradiction between large CT degree required for strong NIR...
关键词：Charge-transfer cocrystal Stoichiometric stacking Crystal growth Photothermal conversion In-situ gelation 
Fabrication of micro spherulitic particles of carbamazepine-hesperetin cocrystal via QESD with enhanced manufacturability and dissolution
《Particuology》2024年第10期11-21,共11页Jinbo Ouyang Lishan Liu Zichen Ning Zhuoshan Gong Limin Zhou Feiqiang He Zhi Gao Li Xu Shichao Du Huaiyu Yang 
supported by National Natural Science Foundation of China(grant Nos.22068002 and 22178054);Jiangxi ProvincialNatural Science Foundation(grant Nos.20224ACB213007_and 20232BBH80015);Jiangxi Province Key Laboratory of Synthetic Chemistry(grant No.JXSC202209).
Granulation is an effective method for improving the flowability of drugs, particularly when they are in needle form. Carbamazepine-hesperetin (CBZ-HPE) cocrystal is a needle-like crystal with low solubility and poor ...
关键词：Carbamazepine-hesperetin cocrystal Quasi-emulsion solventdiffusion(QESD) technique Microspheres FLOWABILITY Dissolution rate 
Porphyrin/Fullerene Porous Molecular Cocrystal Featuring a Robust One-Dimensional Channel
《Precision Chemistry》2024年第9期480-487,共8页Nobuhiro Sato Ryojun Toyoda Tetsu Sato Zi Lang Goo Shinya Takaishi Koki Chida Takeharu Yoshii Hirotomo Nishihara Kunihisa Sugimoto Ryota Sakamoto 
supported by JST-FOREST(JPMJFR203F)and JST-CREST(JPMJCR18R3);supported by JSPS KAKENHI Grant Nos.JP23H04612,JP20H02547,21K14490,22KJ0294,22H05142,and 22H05145;Nippon Sheet Glass Foundation for Materials Science and Engineering;the Asahi Glass Foundation for financial support;A part of SXRD measurements was performed at SPring-8 BL02B1 with the approval of the Japan Synchrotron Radiation Research Institute(JASRI)(Proposal Nos.2023B1680,2023B1853).
Microporous molecular crystals are promising materials because of their designable porosity as well as their resistance to chemical and other stimuli.Here,we developed microporous molecular cocrystals by taking advant...
关键词：Microporous molecular crystal intermolecular interaction gas adsorption chemical stability high-pressure resistance 
Cocrystals of carbamazepine:Structure,mechanical properties,fluorescence properties,solubility,and dissolution rate被引量：1
《Particuology》2024年第7期20-30,共11页Jinbo Ouyang Lishan Liu Yin Li Mingyang Chen Limin Zhou Zhirong Liu Li Xu Hamza Shehzad 
National Natural Science Foundation of China(grant No.22068002 and 22178054);Training plan for academic and technical leaders of major disciplines in Jiangxi Province-Youth Talent Project(grant No.20212BCj23001);Jiangxi Provincial Natural Science Foundation(grant No.20224ACB213007,20212ACB203002,and 20232BBH80015);Jiangxi Province Key Laboratory of Synthetic Chemistry(grant No.JXSC202209).
Carbamazepine(CBZ)is an anticonvulsant with very low water solubility,presenting as a white crystalline powder with poor mechanical properties and is hard to bend.To enhance CBZ's physicochemical properties,such as wa...
关键词：CARBAMAZEPINE COCRYSTAL Mechanical properties Fluorescence performance Dissolution rate 
调控动态生长过程以构筑嵌段可换和光谱可调的有机异质结构
《Science China Materials》2024年第7期2153-2160,共8页赵帅 许超飞 余悦 夏星宇 王磊 王雪东 廖良生 
the financial support from the National Natural Science Foundation of China (52173177, 21971185, and 52203234);the Natural Science Foundation of Jiangsu Province (BK20221362);the Science and Technology Support Program of Jiangsu Province (TJ-2022-002);Jiangsu Funding Program for Excellent Postdoctoral Talent (2023ZB580);supported by Suzhou Key Laboratory of Functional Nano & Soft Materials;Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University (KJS2156);Collaborative Innovation Center of Suzhou Nano Science & Technology;the 111 Project;Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD);Joint International Research Laboratory of Carbon Based Functional Materials and Devices;Soochow University Tang Scholar
与单一结构相比,有机嵌段异质结构具有特殊的光电性能.然而,有机分子间的相互作用主导了异质结构构建单元的生长顺序,如有机单元A、B会自发形成BAB型结构而不是相反的ABA型结构,不能可控生长.在此,我们提出了次序结晶工程,结合晶种逐步...
关键词：organic heterostructure charge transfer cocrystal CRYSTALLIZATION optical waveguide 
Theoretical and experimental cocrystal screening of temozolomide with a series of phenolic acids, promising cocrystal coformers被引量：1
《Chinese Chemical Letters》2024年第5期407-417,共11页Hongmei Yu Baoxi Zhang Meiju Liu Cheng Xing Guorong He Li Zhang Ningbo Gong Yang Lu Guanhua Du 
supported by the Beijing Natural Science Foundation(No.7222261);CAMS Innovation Fund for Medical Sciences(Nos.2022-I2M-01-015 and 2022-I2M-JB-010);Key R&D Program of Shan Dong Province(No.2019JZZY020909);Chinese Pharmacopoeia Commission Drug Standard Promoting Fund(No.2022Y01)。
The virtual cocrystal screening approach based on molecular electrostatic potential surface(MEPS)maps is a fast and feasible computational method to estimate the probability of cocrystal formation by calculating the d...
关键词：VIRTUAL COCRYSTAL TEMOZOLOMIDE Supramolecular synthon Phenolic acid Stability 
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