COCRYSTALS

作品数：21被引量：63H指数：3
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相关作者：洪茂椿江飞龙刘自玲更多>>
相关机构：中国科学院福建物质结构研究所中国药科大学更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Science China Chemistry》《Science China Materials》《Journal of Pharmaceutical and Biopharmaceutical Research》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划上海市浦江人才计划项目天津市自然科学基金更多>>
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Pure drug nanomedicines-where we are?
《Chinese Journal of Natural Medicines》2025年第4期385-409,共25页Yaoyao Lai Bing Xie Wanting Zhang Wei He 
supported by the National Natural Science Foundation of China(Nos.82073782 and 82241002)。
Pure drug nanomedicines(PDNs)encompass active pharmaceutical ingredients(APIs),including macromolecules,biological compounds,and functional components.They overcome research barriers and conversion thresholds associat...
关键词：Pure drug nanomedicines Drug nanocrystals Drug-drug cocrystals Antibody-drug conjugates Drug nanoparticles Nanobodies 
Cocrystal pleomorphism-inspired drug nanoassembly for pulmonary-endothelium targeting and pulmonary hypertension treatment
《Acta Pharmaceutica Sinica B》2025年第1期557-570,共14页Makhloufi Zoulikha Jiahui Zou Pei Yang Jun Wu Wei Wu Kun Hao Wei He 
supported by the National Natural Science Foundation of China(Nos.82073782 and 82241002);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(21KJA320003);the Scientific Research Project of Jiangsu Commission of Health(LKZ2023001,China);the Clinical Competence Improvement Project of Jiangsu Province Hospital(JSPH-MB-2022-13,China).
Endothelial dysfunction is one of the early triggers of vascular remodeling during pulmonary hypertension(PH)with complex predisposing mechanisms,mainly via an unbalanced generation of vasoactive factors,increased exp...
关键词：Pulmonary hypertension Inflammation Endothelial dysfunction ENDOTHELIN COCRYSTALS Nanorods BOSENTAN ANDROGRAPHOLIDE 
Solubilization techniques used for poorly water-soluble drugs
《Acta Pharmaceutica Sinica B》2024年第11期4683-4716,共34页Bing Xie Yaping Liu Xiaotong Li Pei Yang Wei He 
National Natural Science Foundation of China(Nos.82073782 and 82241002).
About 40%of approved drugs and nearly 90%of drug candidates are poorly water-soluble drugs.Low solubility reduces the drugability.Effectively improving the solubility and bioavailability of poorly water-soluble drugs ...
关键词：Poorly water-soluble drugs Solubilization techniques Nanocrystals COCRYSTALS Ionic liquids Polymer-based carriers Lipid-based carriers Inorganiccarriers 
Host-guest cocrystals boost thermally activated delayed fluorescence materials
《Science China Chemistry》2024年第10期3179-3180,共2页Wenzhi Yang Jiong Zhou 
Organic light-emitting diodes(OLEDs)play an important role in organic display and lighting fields.Thermally activated delayed fluorescence(TADF)materials have shown great potential in the OLED field because they can t...
关键词：HOST DIODES DELAYED 
Organic stoichiometric cocrystals with a subtle balance of charge-transfer degree and molecular stacking towards high-efficiency NIR photothermal conversion
《Chinese Chemical Letters》2024年第10期180-186,共7页Jieqiong Xu Wenbin Chen Shengkai Li Qian Chen Tao Wang Yadong Shi Shengyong Deng Mingde Li Peifa Wei Zhuo Chen 
supported by the National Natural Science Foundation of China(Nos.22001006,22375002,22273057,22225401);the Anhui Provincial Natural Science Foundation(No.2308085Y10);the Open Project of Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Anhui University,Ministry of Education;The National Key Research and Development Program of China(Nos.2022YFC_(2)403500,2020YFA0210800);The Universities Joint Laboratory of Guangdong,Hong Kong and Macao(No.130/07422011);the Natural Science Foundation of Guangdong Province(No.2022A1515011661);the China Postdoctoral Science Foundation(Nos.2023M730760,2023M740010)。
Charge-transfer(CT)stoichiometric cocrystals are promising choice of organic materials for unveiling the structure-property relationship.However,due to the contradiction between large CT degree required for strong NIR...
关键词：Charge-transfer cocrystal Stoichiometric stacking Crystal growth Photothermal conversion In-situ gelation 
NIR-II Organic Photothermal Cocrystals with Strong Charge Transfer Interaction for Flexible Wearable Heaters
《Chinese Journal of Chemistry》2024年第14期1563-1570,共8页Dong Zhang Shuyu Li Shaosong Gao Siyao Fu Kexin Liu Dan He Huapeng Liu Xiaotao Zhang Wenping Hu 
the National Key R&D Program(2022YFB3603800);the National Natural Science Foundation of China(52121002,U21A6002);Tianjin Natural Science Foundation(20JCJQJC00300);the Fundamental ResearchFunds forthe Central Universities.
The organic cocrystal strategy has provided a convenient and efficient platform for preparing organic photothermal materials.However,the rapidly directional preparation of cocrystals with desirable photothermal proper...
关键词：Organic photothermal cocrystals Charge transfer NiR-II region Density functional calculations Flexible wearable heaters Crystal engineering Orbital hybridization Fluorides 
Cocrystals of carbamazepine:Structure,mechanical properties,fluorescence properties,solubility,and dissolution rate被引量：1
《Particuology》2024年第7期20-30,共11页Jinbo Ouyang Lishan Liu Yin Li Mingyang Chen Limin Zhou Zhirong Liu Li Xu Hamza Shehzad 
National Natural Science Foundation of China(grant No.22068002 and 22178054);Training plan for academic and technical leaders of major disciplines in Jiangxi Province-Youth Talent Project(grant No.20212BCj23001);Jiangxi Provincial Natural Science Foundation(grant No.20224ACB213007,20212ACB203002,and 20232BBH80015);Jiangxi Province Key Laboratory of Synthetic Chemistry(grant No.JXSC202209).
Carbamazepine(CBZ)is an anticonvulsant with very low water solubility,presenting as a white crystalline powder with poor mechanical properties and is hard to bend.To enhance CBZ's physicochemical properties,such as wa...
关键词：CARBAMAZEPINE COCRYSTAL Mechanical properties Fluorescence performance Dissolution rate 
Molecule configurations modulate packing array and charge transfer in cocrystal engineering
《Science China Chemistry》2024年第2期512-516,共5页Shenglong An Mengyuan Qiao Xin Jin Xuanying Chen Jianhua Su Lifang Guo Zhiyun Zhang 
supported by the National Natural Science Foundation of China (22335004,22004036,22175063);the Shanghai Municipal Science&Technology Major Project (2018SHZDZX-03);the 111 Project (B16017);Shanghai Committee of Science&Technology (17520750100);the Program for Eastern Scholar Distinguished Professor。
Organic cocrystal as an emerging assembly strategy has received increasing attention in constructing multiple functional materials,through continually screening suitable constituent monomers or changing their stoichio...
关键词：COCRYSTALS molecular configuration SELF-ADAPTIVE packing mode charge transfer 
Cocrystal engineering:towards high-performance near-infrared organic phototransistors based on donor-acceptor charge transfer cocrystals被引量：1
《Science China Chemistry》2023年第1期266-272,共7页Fei Li Lei Zheng Yajing Sun Shuyu Li Lingjie Sun Fangxu Yang Weibing Dong Xiaotao Zhang Wenping Hu 
supported by the Ministry of Science and Technology of China(2018YFA0703200 and 2017YFA0204503);the National Natural Science Foundation of China(52121002,51733004,U21A6002,51725304 and 21875158);Tianjin Natural Science Foundation(20JCJQJC00300);China Postdoctoral Science Foundation(2021M692381)。
Near-infrared organic phototransistors have wide application prospects in many fields.The active materials with the high mobility and near-infrared response are critical to building high-performance near-infrared orga...
关键词：organic semiconductors charge transporting properties organic cocrystals organic field effect transistors near-infrared organic phototransistors 
Drug-drug cocrystals:Opportunities and challenges被引量：7
《Asian Journal of Pharmaceutical Sciences》2021年第3期307-317,共11页Xiaojuan Wang Shuzhang Du Rui Zhang Xuedong Jia Ting Yang Xiaojian Zhang 
Recently,drug-drug cocrystal attracts more and more attention.It offers a low risk,low-cost but high reward route to new and better medicines and could improve the physiochemical and biopharmaceutical properties of a ...
关键词：Drug-drug cocrystal Drug combination COCRYSTAL Physicochemical property 
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