ANDROGRAPHOLIDE

作品数：63被引量：203H指数：8
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Andrographolide sulfonate alleviates rheumatoid arthritis by inhibiting glycolysis-mediated activation of PI3K/AKT to restrain Th17 cell differentiation
《Chinese Journal of Natural Medicines》2025年第4期480-491,共12页Chunhong Jiang Xi Zeng Jia Wang Xiaoqian Wu Lijuan Song Ling Yang Ze Li Ning Xie Xiaomei Yuan Zhifeng Wei Yi Guan 
supported by the project of Central Funds Guiding the Local Science and Technology Development(No.20212ZDD02010)。
Andrographolide sulfonate(AS)is a sulfonated derivative of andrographolide extracted from Andrographis paniculata(Burm.f.)Nees,and has been approved for several decades in China.The present study aimed to investigate ...
关键词：Andrographolide sulfonate Rheumatoid arthritis Th17 cell differentiation GLYCOLYSIS PI3K/AKT pathway 
Cocrystal pleomorphism-inspired drug nanoassembly for pulmonary-endothelium targeting and pulmonary hypertension treatment
《Acta Pharmaceutica Sinica B》2025年第1期557-570,共14页Makhloufi Zoulikha Jiahui Zou Pei Yang Jun Wu Wei Wu Kun Hao Wei He 
supported by the National Natural Science Foundation of China(Nos.82073782 and 82241002);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(21KJA320003);the Scientific Research Project of Jiangsu Commission of Health(LKZ2023001,China);the Clinical Competence Improvement Project of Jiangsu Province Hospital(JSPH-MB-2022-13,China).
Endothelial dysfunction is one of the early triggers of vascular remodeling during pulmonary hypertension(PH)with complex predisposing mechanisms,mainly via an unbalanced generation of vasoactive factors,increased exp...
关键词：Pulmonary hypertension Inflammation Endothelial dysfunction ENDOTHELIN COCRYSTALS Nanorods BOSENTAN ANDROGRAPHOLIDE 
Activation of pregnane X receptor sensitizes alcoholic steatohepatitis by transactivating fatty acid binding protein 4
《Acta Pharmaceutica Sinica B》2024年第11期4776-4788,共13页Yiwen Zhang Bingfang Hu Shaoxing Guan Pan Li Yingjie Guo Pengfei Xu Yongdong Niu Yujin Li Ye Feng Jiewen Du Jun Xu Xiuchen Guan Jingkai Gu Haiyan Sun Min Huang 
National Natural Science Foundation of China(Grant Nos.82020108031,82404752,81730103,81573507 and 81973398);National Key Research and Development Program(Grant Nos.2017YFC0909300 and 2016YFC0905000,China);Guangdong Provincial Key Laboratory of Construction Foundation(Grant Nos.2017B030314030 and 2020B1212060034,China);Science and Technology Program of Guangzhou(Grant No.201607020031,China);National Engineering and Technology Research Center for New drug Druggability Evaluation Seed Program of Guangdong Province(Grant No.2017B090903004,China);111 project(Grant No.B16047,China);Guangdong Basic and Applied Basic Research Foundation(Grant Nos.2022A1515012549 and 2023A1515012667,China);Marine Medicine Innovation Platform for the Integration of Production and Education Project of Guangdong Provincial Education Department(No.2021CJPT014,China);Shenzhen Stability Support Project for Colleges and Universities(No.20220814205518001,China);Shenzhen Sustainable Development Project(No.KCXFZ20230731094501002,China).
Alcoholic steatohepatitis (ASH) is a liver disease characterized by steatosis, inflammation, and necrosis of the liver tissue as a result of excessive alcohol consumption. Pregnane X receptor (PXR) is a xenobiotic nuc...
关键词：Alcoholic steatohepatitis Fatty acid binding protein 4 Pregnane X receptor Alcoholic liver disease ANDROGRAPHOLIDE Nuclear receptorLiver injury RIFAMPICIN 
Research on Purification Process and Pharmacological Action of Andrographolide
《Medicinal Plant》2024年第5期13-16,共4页Changtao CAI Wenshuang HOU Quan QUAN Jingchao WANG Mingxinzhi WANG Chenghao JIN 
Supported by Heilongjiang Province Key Research and Development Plan Guid-ance Project(GZ20220039),Central Support for Local Universities Reform and Development Fund Talent Training Project(2020GSP16).
This paper reviews the purification process,content determination methods and pharmacological action of Andrographolide,aiming to provide new ideas for the subsequent study of Andrographolide and its related drug deve...
关键词：ANDROGRAPHOLIDE Purification process Content determination Pharmacological action 
Targeting TLR4 and regulating the Keap1/Nrf2 pathway with andrographolide to suppress inflammation and ferroptosis in LPS-induced acute lung injury
《Chinese Journal of Natural Medicines》2024年第10期914-928,共15页LI Yichen HUANG Liting LI Jilang LI Siyuan LV Jianzhen ZHONG Guoyue GAO Ming YANG Shilin HAN Shan HAO Wenhui 
supported by China-ASEAN International Innovative Center for Health Industry of Traditional Chinese Medicine(No.AD20297142);Guangxi Collaborative Innovation Center for Scientific Achievements Transformation and Applicationon Traditional Chinese Medicine(No.05020058)。
Acute lung injury(ALI)is a severe inflammatory condition with a high mortality rate,often precipitated by sepsis.The pathophysiology of ALI involves complex mechanisms,including inflammation,oxidative stress,and ferro...
关键词：ANDROGRAPHOLIDE Acute lung injury Ferroptosis Toll-like receptor 4 Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2-related factor 2 
Andrographolide Attenuates Noise-Induced Hearing Loss by Ameliorating Cochlear Inflammation
《World Journal of Traditional Chinese Medicine》2024年第2期204-212,共9页Meng-Hua Li Wan-Qi Wang Li-Ting Zheng Meng Bing Chen Yang Chu Miao Qiao Zuo-Li Zhang Konduru Naveena Yong Pan Yun-Shi Zhang He Sun Xiao-Hui Ma Xi Shi 
supported by the Science and Technology Development Aid Project of Xuzhou Science and Technology Bureau(KC21249);the Science and Technology Development Project of Chongqing(CSTB2022NSCQ-M SX1598);Hainan Provincial Natural Science Foundation of China(824MS052);TASLY Special Funding 2023;the Scientific Research Startup Foundation of Hainan University。
Objective:This study aimed to explore andrographolide's mechanism of action and its protective effect on noise-induced hearing loss(NIHL).Materials and Methods:A mice animal model for NIHL was established through expo...
关键词：ANDROGRAPHOLIDE ANTI-INFLAMMATORY auditory protection noise-induced hearing loss traditional Chinese medicine compound 
X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway
《World Journal of Diabetes》2024年第6期1299-1316,共18页Ming-Wei Du Xin-Lin Zhu Dong-Xing Zhang Xian-Zhen Chen Li-Hua Yang Jin-Zhou Xiao Wen-Jie Fang Xiao-Chun Xue Wei-Hua Pan Wan-Qing Liao Tao Yang 
Supported by the Shanghai Science and Technology Innovation Project,One Belt One Road International Joint Laboratory of Medical Mycology,No.21410750500。
BACKGROUND Diabetic foot ulcers(DFU),as severe complications of diabetes mellitus(DM),significantly compromise patient health and carry risks of amputation and mortality.AIM To offer new insights into the occurrence a...
关键词：Words:Diabetes mellitus Wound healing NF-E2-related factor-2/HO-1 signaling pathway ANDROGRAPHOLIDE 
Novel wine in an old bottle:Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases被引量：2
《Journal of Pharmaceutical Analysis》2023年第6期563-589,共27页Tingting Gou Minghao Hu Min Xu Yuchen Chen Rong Chen Tao Zhou Junjing Liu Li Guo Hui Ao Qiang Ye 
This research was funded by the National Natural Science Foundation of China(Grant Nos.:81891012 and U19A2010);the National Interdisciplinary Innovation TeamProgram of Traditional Chinese Medicine(Grant No.:ZYYCXTD-D-202209);Chinese Medicine Science and Technology Industry Innovation Team Program of Sichuan Province(Grant No.:2022C001);Chengdu University of Traditional Chinese Medicine“Xinglin Scholars”Discipline Talent Research Promotion Program(Grant No.:XCZX2022010).
Atherosclerotic cardiovascular disease(ASCVD)frequently results in sudden death and poses a serious threat to public health worldwide.The drugs approved for the prevention and treatment of ASCVD are usually used in co...
关键词：ANDROGRAPHOLIDE ATHEROSCLEROSIS Atherosclerotic cardiovascular disease Pharmacological effects Pharmacokinetics properties Toxicity 
Construction and agrochemical efficacy of novel indolo[2,3-b]andrographolide derivatives
《Advanced Agrochem》2023年第4期349-355,共7页Meng Hao Min Lv Tianze Li Hui Xu 
supported by the National Natural Science Foundation of China(Project No.32072442).
To find new pesticide candidates,by using of a natural product andrographolide as the precursor,a series of novel indolo[2,3-b]andrographolide derivatives were semisynthesized by Fischer-indole rearrangement reaction....
关键词：ANDROGRAPHOLIDE INDOLE Structural modifications Insecticidal activities SEM 
Author correction to"DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis"[Acta Pharmaceutica Sinica B 12(2022)262-273]
《Acta Pharmaceutica Sinica B》2023年第7期3177-3177,共1页
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