Novel wine in an old bottle:Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases  

作　　者：Tingting Gou Minghao Hu Min Xu Yuchen Chen Rong Chen Tao Zhou Junjing Liu Li Guo Hui Ao Qiang Ye 

机构地区：[1]State Key Laboratory of Southwestern Chinese Medicine Resources,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China [2]School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China [3]Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China

出　　处：《Journal of Pharmaceutical Analysis》2023年第6期563-589,共27页药物分析学报（英文版）

基　　金：This research was funded by the National Natural Science Foundation of China(Grant Nos.:81891012 and U19A2010);the National Interdisciplinary Innovation TeamProgram of Traditional Chinese Medicine(Grant No.:ZYYCXTD-D-202209);Chinese Medicine Science and Technology Industry Innovation Team Program of Sichuan Province(Grant No.:2022C001);Chengdu University of Traditional Chinese Medicine“Xinglin Scholars”Discipline Talent Research Promotion Program(Grant No.:XCZX2022010).

摘　　要：Atherosclerotic cardiovascular disease(ASCVD)frequently results in sudden death and poses a serious threat to public health worldwide.The drugs approved for the prevention and treatment of ASCVD are usually used in combination but are inefficient owing to their side effects and single therapeutic targets.Therefore,the use of natural products in developing drugs for the prevention and treatment of ASCVD has received great scholarly attention.Andrographolide(AG)is a diterpenoid lactone compound extracted from Andrographis paniculata.In addition to its use in conditions such as sore throat,AG can be used to prevent and treat ASCVD.It is different from drugs that are commonly used in the prevention and treatment of ASCVD and can not only treat obesity,diabetes,hyperlipidaemia and ASCVD but also inhibit the pathological process of atherosclerosis(AS)including lipid accumulation,inflammation,oxidative stress and cellular abnormalities by regulating various targets and pathways.However,the pharmacological mechanisms of AG underlying the prevention and treatment of ASCVD have not been corroborated,which may hinder its clinical development and application.Therefore,this review summarizes the physiological and pathological mechanisms underlying the development of ASCVD and the in vivo and in vitro pharmacological effects of AG on the relative risk factors of AS and ASCVD.The findings support the use of the old pharmacological compound(‘old bottle’)as a novel drug(‘novel wine’)for the prevention and treatment of ASCVD.Additionally,this review summarizes studies on the availability as well as pharmaceutical and pharmacokinetic properties of AG,aiming to provide more information regarding the clinical application and further research and development of AG.

关 键 词：ANDROGRAPHOLIDE ATHEROSCLEROSIS Atherosclerotic cardiovascular disease Pharmacological effects Pharmacokinetics properties Toxicity 

分 类 号：R285[医药卫生—中药学]