Construction and agrochemical efficacy of novel indolo[2,3-b]andrographolide derivatives  

作　　者：Meng Hao Min Lv Tianze Li Hui Xu 

机构地区：[1]College of Plant Protection,Northwest A&F University,Yangling,712100,China

出　　处：《Advanced Agrochem》2023年第4期349-355,共7页现代农业化学（英文）

基　　金：supported by the National Natural Science Foundation of China(Project No.32072442).

摘　　要：To find new pesticide candidates,by using of a natural product andrographolide as the precursor,a series of novel indolo[2,3-b]andrographolide derivatives were semisynthesized by Fischer-indole rearrangement reaction.Their structures were identified by 1H NMR,IR,mp,and HRMS,and the steric configuration of compound Ic was further determined on single-crystal analysis.Compounds If and IIb showed 5.9 and 7.0 times potent acaricidal activity compared to andrographolide against Tetranychus cinnabarinus.Compound Ib displayed 4.2 folds higher aphicidal activity compared to andrographolide against Eriosoma lanigerum.In addition,the pronounced insecticidal activity of compound IIc against Aphis citricola was 4.2 folds of that of andrographolide.Scanning electron microscopy revealed that compound IIb can destroy the epidermis of T.cinnabarinus.These results can provide a basis for future research on botanical agrochemicals.

关 键 词：ANDROGRAPHOLIDE INDOLE Structural modifications Insecticidal activities SEM 

分 类 号：O62[理学—有机化学]