Andrographolide Attenuates Noise-Induced Hearing Loss by Ameliorating Cochlear Inflammation  

作　　者：Meng-Hua Li Wan-Qi Wang Li-Ting Zheng Meng Bing Chen Yang Chu Miao Qiao Zuo-Li Zhang Konduru Naveena Yong Pan Yun-Shi Zhang He Sun Xiao-Hui Ma Xi Shi 

机构地区：[1]Artificial Auditory Laboratory of Jiangsu Province,Xuzhou Medical University,Xuzhou,China [2]Key Laboratory of Tropical Biological Resources of Ministry of Education,School of Pharmaceutical Sciences,Hainan University,Haikou,China [3]Department of ENT,Beijing Friendship Hospital,Capital Medical University,Beijing,China [4]National Key Laboratory of Chinese Medicine Modernization,Tasly Academy,Tasly Pharmaceutical Group Co.,Ltd.,Tianjin,China [5]Endoscopy Center,Ankang People's Hospital,Ankang,China [6]Department of Respiratory Medicine,Xuzhou Infectious Diseases Hospital,Affiliated Hospital of Xuzhou Medical University,Xuzhou,China [7]Department of ENT,The People's Hospital of Rongchang District,Chongqing,China

出　　处：《World Journal of Traditional Chinese Medicine》2024年第2期204-212,共9页世界中医药杂志（英文）

基　　金：supported by the Science and Technology Development Aid Project of Xuzhou Science and Technology Bureau(KC21249);the Science and Technology Development Project of Chongqing(CSTB2022NSCQ-M SX1598);Hainan Provincial Natural Science Foundation of China(824MS052);TASLY Special Funding 2023;the Scientific Research Startup Foundation of Hainan University。

摘　　要：Objective:This study aimed to explore andrographolide's mechanism of action and its protective effect on noise-induced hearing loss(NIHL).Materials and Methods:A mice animal model for NIHL was established through exposure to broadband noise at 120 d B sound pressure level for 4 h.Transcriptomics analysis and pharmacodynamic experiments were carried out.Results:Andrographolide enters the inner ear and effectively prevents hearing damage following noise exposure in the mice model for permanent hearing loss.Moreover,treatment with andrographolide inhibited the excessive activation of inflammatory factors in the cochleae of noise-exposed mice.Conclusion:Andrographolide might be a promising candidate for auditory protective drug investigation.

关 键 词：ANDROGRAPHOLIDE ANTI-INFLAMMATORY auditory protection noise-induced hearing loss traditional Chinese medicine compound 

分 类 号：R285.5[医药卫生—中药学]