Cocrystals of carbamazepine:Structure,mechanical properties,fluorescence properties,solubility,and dissolution rate  

作　　者：Jinbo Ouyang Lishan Liu Yin Li Mingyang Chen Limin Zhou Zhirong Liu Li Xu Hamza Shehzad 

机构地区：[1]School of Chemistry and Materials Science,East China University of Technology,Nanchang 330013,China [2]School of Physics and Materials Science,Nanchang University,Nanchang 330013,China [3]School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China

出　　处：《Particuology》2024年第7期20-30,共11页颗粒学报（英文版）

基　　金：National Natural Science Foundation of China(grant No.22068002 and 22178054);Training plan for academic and technical leaders of major disciplines in Jiangxi Province-Youth Talent Project(grant No.20212BCj23001);Jiangxi Provincial Natural Science Foundation(grant No.20224ACB213007,20212ACB203002,and 20232BBH80015);Jiangxi Province Key Laboratory of Synthetic Chemistry(grant No.JXSC202209).

摘　　要：Carbamazepine(CBZ)is an anticonvulsant with very low water solubility,presenting as a white crystalline powder with poor mechanical properties and is hard to bend.To enhance CBZ's physicochemical properties,such as water solubility and mechanical properties,we selected six cocrystal coformers(CCFs):nicotinamide(NIC),benzamide(BZM),salicylic acid(SCA),fumaric acid(FMA),trimesic acid(TMA),and hesperetin(HPE).Six CBZ cocrystals were successfully prepared using the solution method.Fourier transform infrared spectroscopy(FT-IR),powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC),and single crystal X-ray diffraction(SCXRD)were used to characterize the crystal structures and gain comprehensive insights into the six cocrystals.The mechanical,fluorescence,and solubility properties of the six cocrystals were tested.The results reveal that most of the prepared cocrystals exhibit improved water solubility and mechanical properties when compared to CBZ.Among them,the dissolution rate of cocrystals excluded from CBZ-HPE has increased by an average of 3 or 4 times compared to CBZ,while CBZ-HPE exhibits superior mechanical properties.Moreover,all six cocrystals possess better fluorescence performance than CBZ.We thoroughly evaluated the mechanical properties of the cocrystals through both experimental and theoretical approaches.This work provides a new direction for studying drug cocrystals to improve the physicochemical properties of drugs.

关 键 词：CARBAMAZEPINE COCRYSTAL Mechanical properties Fluorescence performance Dissolution rate 

分 类 号：O657.3[理学—分析化学]