TEMOZOLOMIDE

作品数：84被引量：243H指数：9
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相关领域：医药卫生更多>>
相关作者：张琳曲迅徐洋洋倪石磊韩晶更多>>
相关机构：山东大学中国医科大学第二军医大学中山医学大学更多>>
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相关基金：国家自然科学基金国家教育部博士点基金天津市自然科学基金沈阳市科技计划项目更多>>
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Cancer cell membrane-camouflaged biomimetic nanoparticles for enhancing chemo-radiation therapy efficacy in glioma
《Journal of Biomedical Research》2025年第1期87-102,共16页Chunming Tang Yanling Wang Min Wu Zhiji Wang Yupeng Zhou Ya Lin Yijun Wang Huae Xu 
supported by the National Natural Science Foundation of China(Grant Nos.82073308 and 82104089)。
Glioblastoma multiforme(GBM)is a highly aggressive and lethal brain tumor with limited treatment options.To improve therapeutic efficacy,we developed a novel multifunctional nanoplatform,GM@P(T/S),comprised of polymer...
关键词：glioblastoma multiforme TEMOZOLOMIDE superparamagnetic iron oxide chemo-radiation therapy cancer cell membrane-coating 
Temozolomide and capecitabine regimen as first-line treatment in advanced gastroenteropancreatic neuroendocrine tumors at a Latin American reference center
《World Journal of Gastrointestinal Oncology》2024年第12期4675-4684,共10页Wagner Eduardo Cruz-Diaz Victor Paitan Jersinho Medina Raymundo Flores Juan Haro-Varas Raul Mantilla Victor Castro-Oliden 
BACKGROUND Numerous studies have indicated that the temozolomide and capecitabine regimen(TEMCAP)exhibits a certain level of efficacy in treating advanced,welldifferentiated gastroenteropancreatic neuroendocrine tumor...
关键词：WELL-DIFFERENTIATED Gastroenteropancreatic neuroendocrine tumors CAPECITABINE TEMOZOLOMIDE Retrospective study Treatment CHEMOTHERAPY 
A new nano approach to prevent tumor growth in the local treatment of glioblastoma: Temozolomide and rutin-loaded hybrid layered composite nanofiber
《Asian Journal of Pharmaceutical Sciences》2024年第6期101-122,共22页Melis Ercelik Cagla Tekin Melisa Gurbuz Yagmur Tuncbilekli Hazal Yılmaz Dogan Busra Mutlu Pınar Eser Gulcin Tezcan Fatma Nur Parın Kenan Yildirim Mehmet Sarihan Gurler Akpinar Murat Kasap Ahmet Bekar Hasan Kocaeli Mevlut Ozgur Taskapilioglu Secil Ak Aksoy Rıfat Ozpar Bahattin Hakyemez Berrin Tunca 
This study was supported by Scientific and Technological Research Council of Turkey(TUBITAK)under the Grant Number 121S624.
Total resection of glioblastoma(GB)tumors is nearly impossible,and systemic administration of temozolomide(TMZ)is often inadequate.This study presents a hybrid layered composite nanofiber network(LHN)designed for loca...
关键词：GLIOBLASTOMA Local treatment TEMOZOLOMIDE RUTIN Hybrid layered composite nanofiber network 
Sintilimab (anti-PD-1 antibody) combined with high-dose methotrexate, temozolomide, and rituximab (anti-CD20 antibody) in primary central nervous system lymphoma: a phase 2 study
《Signal Transduction and Targeted Therapy》2024年第10期4554-4563,共10页Zhiyong Zeng Apeng Yang Jingke Yang Sheng Zhang Zhen Xing Xingfu Wang Wenzhong Mei Changzhen Jiang Junfang Lin Xiyue Wu Yihui Xue Zanyi Wu Lianghong Yu Dengliang Wang Jianwu Chen Shufa Zheng Qiaoxian Lin Qingjiao Chen Jinfeng Dong Xiaoqiang Zheng Jizhen Wang Jinlong Huang Zhenying Chen Ping Chen Meihong Zheng Xiaofang Zhou Youwen He Yuanxiang Lin Junmin Chen 
https://doi.org/10.1038/s41392-024-01941-x Fujian Provincial Health Technology Project[grant number 2023CXA028];Joint Funds for the Innovation of Science and Technology,Fujian Province(grant number 2023Y9021);National Science Foundation of Fujian Province[grant number 2022J02036];Clinical research project of Wu Jieping Medical Foundation[grant number 320.6750.19094-41];National Natural Science Foundation of China[grant number 82070218,81400160].
Primary central nervous system lymphoma(PCNSL)is a rare and frequently fatal lymphoma subtype.The programmed death-1(PD-1)pathway has emerged as a potential therapeutic target,but the effectiveness of PD-1 antibody si...
关键词：METHOTREXATE LYMPHOMA system 
Transcriptomic analysis identifies the neuropeptide cortistatin (CORT) as an inhibitor of temozolomide (TMZ) resistance by suppressing the NF-kB-MGMT signaling axis in human glioma
《Genes & Diseases》2024年第3期385-399,共15页Zongze He Bo Peng Qi Wang Jie Tian Ping Liu Jie Feng Yiwei Liao Longyi Chen Ping Jia Jian Tang 
supported by grants from the Department of Science and Technology of Sichuan Province,China(No.23ZDYF2212,23ZDYF2098);the Foundation for Sichuan Provincial People's Hospital(Sichuan,China)(No.2022QN06);Medico-Engineering Cooperation Funds from the University of Electronic Science and Technology of China(No.ZYGX2021YGLH209)and 2022 Tianfu Qingcheng Project,China.
Glioma is a common tumor originating in the brain that has a high mortality rate.Temozolomide(TMZ)is the first-line treatment for high-grade gliomas.However,a large pro-portion of gliomas are resistant to TMZ,posing a...
关键词：CORTISTATIN Glioma MGMT NF-kB pathway TEMOZOLOMIDE 
UBE2C enhances temozolomide resistance by regulating the expression of p53 to induce aerobic glycolysis in glioma被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第6期916-926,共11页Kun Zhou Dexin Wang Xiaolin Du Xia Feng Xiaoxi Zhu Cheng Wang 
supported by the grants from the Science and Technology Foundation of Guizhou Provincial Health and Family Planning Commission(Nos.gzwjkj2019-1-145,gzwkj2023-036,and Gzwjkj2017-1-026);the Postgraduate Research Foundation of Guizhou Province(QIAN JIAO HE YJSKYJJ[2021]206);the Guizhou Province Science and Technology Planning Project[Guizhou Genetic Basis-ZK[2023]General 326];the Guizhou Provincial Health Commission(No.gzwkj2023-036).
UBE2C is overexpressed in gliomas,and its overexpression has been reported to be correlated with the drug resistance of gliomas to some extent.In this study,we explore the role of UBE2C in regulating temozolomide(TMZ)...
关键词：UBE2C P53 TMZ resistance aerobic glycolysis GLIOMA 
Theoretical and experimental cocrystal screening of temozolomide with a series of phenolic acids, promising cocrystal coformers被引量：1
《Chinese Chemical Letters》2024年第5期407-417,共11页Hongmei Yu Baoxi Zhang Meiju Liu Cheng Xing Guorong He Li Zhang Ningbo Gong Yang Lu Guanhua Du 
supported by the Beijing Natural Science Foundation(No.7222261);CAMS Innovation Fund for Medical Sciences(Nos.2022-I2M-01-015 and 2022-I2M-JB-010);Key R&D Program of Shan Dong Province(No.2019JZZY020909);Chinese Pharmacopoeia Commission Drug Standard Promoting Fund(No.2022Y01)。
The virtual cocrystal screening approach based on molecular electrostatic potential surface(MEPS)maps is a fast and feasible computational method to estimate the probability of cocrystal formation by calculating the d...
关键词：VIRTUAL COCRYSTAL TEMOZOLOMIDE Supramolecular synthon Phenolic acid Stability 
Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase Ⅱ trial
《Cancer Biology & Medicine》2024年第5期433-444,共12页Shuzhen Lai Peijing Li Xiaohui Liu Guihong Liu Tieming Xie Xing Zhang Xiaoxuan Wang Jing Huang Yiqiang Tang Zhigang Liu Guoping Shen Chaoming Li Fangxiao Lu Lei Wang Fagui Jiang Caixing Sun Yuanyuan Chen Ming Chen 
supported by the National Natural Science Foundation of China(Grant No.82272744);Natural Science Foundation of Guangdong Province(Grant No.2022A1515010814);Sun Yat-sen University Clinical Research 5010 Program(Grant No.2022008).
Objective:Glioblastomas are highly vascularized malignant tumors.We determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor,anlotinib,for a newly diagnosed glioblastoma.Methods:This multicente...
关键词：GLIOBLASTOMA ANTI-ANGIOGENESIS multi-kinase inhibitor anlotinib TEMOZOLOMIDE progression-free survival 
Extended cycles of adjuvant temozolomide improves survival outcomes in glioblastoma:a retrospective analysis
《Journal of Cancer Metastasis and Treatment》2024年第1期348-361,共14页Hao Xu Shengnan Yu Chunyan Wang Yue Hu Qinglan Ren Lihao Jiang 
supported by the National Natural Science Foundation of China(No.82203007).
Aim:Standard treatment includes post-surgical chemoradiotherapy and adjuvant temozolomide(TMz)for glioblastoma(GBM).There is no consensus on the optimal duration for adjuvant TMZ.This study assessed whether prolonging...
关键词：GLIOBLASTOMA adjuvant temozolomide MGMT promoter methylation overall survival 
Glioblastoma cell-derived exosomes functionalized with peptides as efficient nanocarriers for synergistic chemotherapy of glioblastoma with improved biosafety被引量：2
《Nano Research》2023年第12期13283-13293,共11页Ying Zhou Long Wang Lufei Chen Wei Wu Zhimin Yang Yuanzhuo Wang Anqi Wang Sujun Jiang Xuzhen Qin Zucheng Ye Zhiyuan Hu Zihua Wang 
supported by the National Natural Science Foundation of China(Nos.32027801,81801766,and 31870992);the Strategic Priority Research Program of Chinese Academy of Sciences(Nos.XDB36000000 and XDB38010400);Science and Technology Service Network Initiative of the Chinese Academy of Sciences(No.KFJ-STS-ZDTP-079),CAS-JSPS(No.GJHZ2094);National High-Level Hospital Clinical Research Funding(No.2022-PUMCH-A-059);Fujian Medical University Foundation for the Introduction of Talents(Nos.XRCZX2019018,XRCZX2017020,and XRCZX2019005);the Joint Funds for the innovation of science and Technology Fujian Province(No.2019Y9001);the Natural Science Foundation of Fujian Province(Nos.2020J01599,2022J01203,and 2022J01666);the Natural Science Foundation of Tibet Autonomous Region(No.XZ2021ZRZY13(Z)).
Glioblastoma(GBM)has been regarded as one of the most deadly and challenging cancers to treat with extremely poor prognosis.The limited efficacy of current chemotherapies might be attributed to the presence of glioma ...
关键词：GLIOBLASTOMA tumor-derived exosome peptide TEMOZOLOMIDE doxorubicin targeted chemotherapy 
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