Cancer cell membrane-camouflaged biomimetic nanoparticles for enhancing chemo-radiation therapy efficacy in glioma  

作　　者：Chunming Tang Yanling Wang Min Wu Zhiji Wang Yupeng Zhou Ya Lin Yijun Wang Huae Xu 

机构地区：[1]Department of Pharmaceutics,School of Pharmacy,Nanjing Medical University,Nanjing,Jiangsu 211166,China [2]Department of Pharmacy,the Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210003,China

出　　处：《Journal of Biomedical Research》2025年第1期87-102,共16页生物医学研究杂志(英文版)

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.82073308 and 82104089)。

摘　　要：Glioblastoma multiforme(GBM)is a highly aggressive and lethal brain tumor with limited treatment options.To improve therapeutic efficacy,we developed a novel multifunctional nanoplatform,GM@P(T/S),comprised of polymeric nanoparticles coated with GBM cell membranes as well as co-loaded with temozolomide(TMZ)and superparamagnetic iron oxide(SPIO)nanoparticles.The successful preparation was confirmed in terms of particle size,morphology,stability,the in vitro drug release,and cellular uptake assays.We demonstrated that GM@P(T/S)exhibited the enhanced homotypic targeting,the prolonged blood circulation,and efficient bloodbrain barrier penetration in both in vitro and in vivo studies.The combination of TMZ and SPIO nanoparticles within GM@P(T/S)synergistically improved chemo-radiation therapy,leading to a reduced tumor growth,an increased survival,and minimal systemic toxicity in the orthotopic GBM mouse models.Our findings suggest that GM@P(T/S)holds a great promise as a targeted and efficient therapeutic strategy for GBM.

关 键 词：glioblastoma multiforme TEMOZOLOMIDE superparamagnetic iron oxide chemo-radiation therapy cancer cell membrane-coating 

分 类 号：R943[医药卫生—药剂学]