云南高校图书馆联盟文献共享服务平台- PRODRUGS

PRODRUGS: 作品数：67被引量：102H指数：5; 导出分析报告; 相关领域：医药卫生化学工程更多>>; 相关作者：张礼和谢璐佳郭颖卢俊峰徐靖源更多>>; 相关机构：中国医学科学院北京协和医学院北京大学香港城市大学天津医科大学更多>>; 相关期刊：《Smart Molecules》《Chemical Research in Chinese Universities》《Natural Science》《Journal of Biosciences and Medicines》更多>>; 相关基金：国家自然科学基金天津市自然科学基金中国博士后科学基金教育部留学回国人员科研启动基金更多>>

An enzyme-gated bioorthogonal catalytic nanoreactor for tumor specific prodrug activation: 《Nano Research》2025年第2期557-570,共14页Yuheng Guo Fang Jiang Xiaohui Zhu Wen He Sijie Song Xuecen Shou Mengnan Wu Ting Wu Tingjing Huang Zhi Ye Xuyang Wang Zhitong Chen Yu He Yuhang Yao Zhaowei Chen Huanghao Yang; This work was funded by the National Key Research and Development Program of China(No.2020YFA0210800,H.H.Y.);the Major Project of Science and Technology of Fujian Province(No.2020HZ06006,H.H.Y.);the National Natural Science Foundation of China(Nos.22421002,22027805,and 22334004,H.H.Y.,Nos.22107019,and 22277011,Z.W.C.,No.22404025,Y.H.Y.);the Research project of General Administration of Customs of PRC(No.2024HK008,X.H.Z.).; Bioorthogonal catalysis mediated by abiotic transition metal catalysts(TMCs)is emerging as a momentum-gathering strategy for in situ generation of therapeutics.However,the unpredictable leakage and deposition of TMCs ...; 关键词：bioorthogonal catalysis PRODRUGS enzyme-gated catalyst immobilization cancer therapy

Unlocking Biomolecular Activity through Pd-Catalyzed Azides Reduction: 《Chinese Journal of Chemistry》2024年第19期2305-2315,共11页Fang Fu Wei Xiong Xinyan Xu Yongjie Liu Ming Li Qianqian Qi Xingyu Liu Yuanyuan Zhang Tian Tian Xiang Zhou; the National Natural Science Foundation of China(Nos.22177089,21721005,92153303,22037004,22177088);the Fundamental Research Funds for the Central Universities(2042021kf0211);Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(Grant No.ZNJC202309).; Comprehensive Summary Pd-mediated bioorthogonal cleavage reactions have been extensively utilized in the activation of prodrug molecules,precise regulation of protein function,and cellular engineering.However,the avai...; 关键词：Decaging strategy PD-CATALYZED Azides reduction Biomolecular activation RNA regulation Biological activity Bioorganic chemistry PRODRUGS

Recent progress in stimuli-activable metallo-prodrugs for cancer therapy: 《Smart Molecules》2024年第3期14-38,共25页Jinzhe Liang Fangmian Wei Hui Chao; supported by the National Natural Science Foundation of China(Nos.22120102002 and 92353301);the Science and Technology Innovation Program of Hunan Province of China(No.2021RC5028).; The clinical approval of platinum-based drugs has prompted the development of novel metallo-complexes during the last several decades,while severe problems,especially for poor water solubility,drug resistance and toxi...; 关键词：cancer therapy metallo-prodrugs stimuli-activable

Exploring Ester Prodrugs: A Comprehensive Review of Approaches, Applications, and Methods: 《Pharmacology & Pharmacy》2024年第8期269-284,共16页Guangyang Zhou; The review provides an overview of the approaches, applications, and methods for ester prodrugs. Ester prodrugs are pharmacologically inactive compounds in their original form but become active drugs on biotransformat...; 关键词：Ester Prodrugs Solubility BIOAVAILABILITY Stability Ester Prodrug Approaches Simple Ester Prodrugs Amino Acid Ester Prodrugs Sugar Ester Prodrugs Lipid Ester Prodrugs Polymeric Ester Prodrugs Esterase-Responsive Nanoparticles Hydrolysis Cancer Treatment Cardiovascular Diseases Neurological Disorders

Targeting AMPKa1 Gene in PC3 Cells by Triphenylmethanol Derivatives: 《Natural Science》2024年第7期111-120,共10页William Yaw Boadi Jamari Jemison Kennedy Welbert Sanaa Dudley Tayalla Hizer Ryan Beni; Epidemiological studies indicate that treatment with metformin, an AMP-activated protein kinase (AMPK) activator, reduces the incidence of cancers. Activation of AMPK has also been reported to oppose tumor progression...; 关键词：PRODRUGS AMP-Activated Protein Kinase POLYPHENOLS Prostate Cancer Triphenylmethanol

Erratum to:Balancing efficacy and safety of doxorubicin-loaded albumin nanoparticles utilizing pH-sensitive doxorubicin-fatty acid prodrugs: 《Nano Research》2024年第7期6774-6775,共2页Yuanhao Yu Shiyi Zuo Jiaxuan Song Lingxiao Li Tian Liu Jiayu Guo Yaqiao Li Danping Wang Qi Lu Helin Wang Dun Zhou Zhonggui He Xiaohong Liu Bingjun Sun Jin Sun; The Hoechst and DOX tunnel images of the DOX-C_(22) ANPs group at 4 h in Fig.4(a)were mistakenly used with the neighboring images of DOX-C_(26) ANPs group.The images were corrected as follows to be correspondence with...; 关键词：group. utilizing loaded

Balancing efficacy and safety of doxorubicin-loaded albumin nanoparticles utilizing pH-sensitive doxorubicin-fatty acid prodrugs: 《Nano Research》2024年第6期5491-5500,共10页Yuanhao Yu Shiyi Zuo Jiaxuan Song Lingxiao Li Tian Liu Jiayu Guo Yaqiao Li Danping Wang Qi Lu Helin Wang Dun Zhou Zhonggui He Xiaohong Liu Bingjun Sun Jin Sun; the National Key R&D Program of China(No.2022YFE0111600);National Natural Science Foundation of China(Nos.82272151 and 82204318)。; Albumin nanoparticles(ANPs)offer unique advantages for antitumor drug delivery system,including non-immunogenicity and inherent tumor-targeting capacity.At present,only a few products,such as ABRAXANE®and FYARRO™,have...; 关键词：fatty acid prodrug ALBUMIN DOXORUBICIN pH-sensitive bond NANOMEDICINES

Practical Synthesis of Valbenazine via 1,3-Dipolar Cycloaddition: 《Chinese Journal of Chemistry》2024年第8期841-845,共5页Yalan Peng Zuming Lin Lili Zhu Shiqing Han Sha-Hua Huang Ran Hong; the National Natural Science Foundation of China(22271194 and 22371295);the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture(Grant No.XTD 2210);the Science and Technology Commission of Shanghai Municipality(20XD1404700)is greatly appreciated.; Comprehensive Summary,Valbenazine(Ingrezza),a potent and highly selective inhibitor of vesicular monoamine transporter type 2(VMAT2)through the active metabolite hydrotetrabenazine(HTBZ),has been approved for the trea...; 关键词：CYCLOADDITION CHEMOENZYMATIC Kinetic resolution PRODRUGS VMAT2 inhibitor

Fine-tuning the activation behaviors of ternary modular cabazitaxel prodrugs for efficient and on-target oral anti-cancer therapy: 《Asian Journal of Pharmaceutical Sciences》2024年第2期188-203,共16页Mingyang Zhang Yifan Miao Can Zhao Tong Liu Xiyan Wang Zixuan Wang Wenxin Zhong Zhonggui He Chutong Tian Jin Sun; supported by National Natural Science Foundation of China(No.82173766,82104109);Natural Science Foundation of Liaoning Province(2022-BS158);Liaoning Province Applied Basic Research Program(No.2022JH2/101300097);National Key R&D Program of China(No.2022YFE0111600).; The disulfide bond plays a crucial role in the design of anti-tumor prodrugs due to its exceptional tumor-specific redox responsiveness. However, premature breaking of disulfide bonds is triggered by small amounts of ...; 关键词：Steric disulfide bond Triglyceride-like pr odrugs CABAZITAXEL Lymphatic transport Oral chemotherapy

Emerging non-antibody‒drug conjugates (non-ADCs) therapeutics of toxins for cancer treatment: 《Acta Pharmaceutica Sinica B》2024年第4期1542-1559,共18页Xiaolan Xu Jiaming Zhang Tao Wang Jing Li Yukang Rong Yanfang Wang Chenxia Bai Qing Yan Xiaohua Ran Yingli Wang Tianhong Zhang Jin Sun Qikun Jiang; This work was supported by the National Postdoctoral Foundation of China(No.2023M730375);Liaoning Province Department of Education Project(No.LJKMZ20221365,China);the State Key Laboratory of Natural and Biomimetic Drugs(No.K202215,China);the National Natural Science Foundation of China(No.82173766);Liaoning Province Applied Basic Research Program(No.2022JH2/101300097,China);the Natural Science Foundation of Shandong Province(No.ZR2021QH084,China)。; The non-selective cytotoxicity of toxins limits the clinical relevance of the toxins.In recent years,toxins have been widely used as warheads for antibody-drug conjugates(ADCs)due to their eff-cient killing activity a...; 关键词：TOXINS Non-antibody-drug conjugates Delivery strategies PRODRUGS Nano drug delivery systems Biomimetic drugdelivery systems Combination strategies Cancer treatment

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