NANOMEDICINES

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Developing mRNA Nanomedicines with Advanced Targeting Functions
《Nano-Micro Letters》2025年第7期53-106,共54页Ji Wang Lijun Cai Ning Li Zhiqiang Luo Haozhen Ren Bing Zhang Yuanjin Zhao 
supported by the National Key Research and Development Program of China(2022YFA1105304);the National Natural Science Foundation of China(T2225003 and 61927805);the Nanjing Medical Science and Technique Development Foundation(ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);the Jiangsu Funding Program for Excellent Postdoctoral Talent(2023ZB032);the Natural Science Foundation of Jiangsu Province(BK20240223);the Project of Institute of Chinese Medicine of Nanjing University(ICM2024011);the Aid Project of Nanjing Drum Tower Hospital Health,Education&Research Foundation.
The emerging messenger RNA(mRNA)nanomedicines have sprung up for disease treatment.Developing targeted mRNA nanomedicines has become a thrilling research hotspot in recent years,as they can be precisely delivered to s...
关键词：MRNA Delivery system Targeted therapy DISEASES Precision medicine 
Pure drug nanomedicines-where we are?
《Chinese Journal of Natural Medicines》2025年第4期385-409,共25页Yaoyao Lai Bing Xie Wanting Zhang Wei He 
supported by the National Natural Science Foundation of China(Nos.82073782 and 82241002)。
Pure drug nanomedicines(PDNs)encompass active pharmaceutical ingredients(APIs),including macromolecules,biological compounds,and functional components.They overcome research barriers and conversion thresholds associat...
关键词：Pure drug nanomedicines Drug nanocrystals Drug-drug cocrystals Antibody-drug conjugates Drug nanoparticles Nanobodies 
DELIVER:The core principles for the clinic translation of nanomedicines
《Acta Pharmaceutica Sinica B》2025年第2期1196-1198,共3页Chuan Hu Xinling He Huile Gao Jinming Zhang 
supported by the Postdoctoral Fellowship Program of CPSF(No.GZC20230333,China).
Nanomedicines have revolutionized disease prevention,diagnosis,and treatment.Since the approval of Liposomal doxorubicin(Doxil)in 1995,various nanomedicines have been successfully developed1.Specifically,the COVID-19 ...
关键词：NANOMEDICINES Clinic translation DELIVER 
Recent advances in the bench-to-bedside translation of cancer nanomedicines
《Acta Pharmaceutica Sinica B》2025年第1期97-122,共26页Yang Liu Yinchao Zhang Huikai Li Tony Y.Hu 
supported by the National Natural Science Foundation of China(No.82202603);the Scientific Research Plan Project initiated by the Tianjin Municipal Education Commission(No.2022ZD066,China);the Science and Technology Project of Tianjin Municipal Health Commission(No.TJWJ2021QN008,China).
Cancer remains a complex and challenging medical problem,driving extensive research efforts.Despite significant progress in understanding its genetic and molecular aspects,the quest for effective treatments continues....
关键词：Cancer nanomedicines Clinical translation Clinical trial landscape ANTICANCER Tumor microenvironment Combination therapies Clinical nanotechnology Drug delivery systems 
Priming immunity via herbal components and their nanomedicines for the treatment of cancer
《Acupuncture and Herbal Medicine》2024年第4期436-462,共27页Xiang Li Chenkai Gong Abid Naeem Jing Liu Ming Yang Jing Zhang Hongming Shang 
the National Natural Science Foundation of China(82260695,82360781);the Jiangxi Provincial Natural Science Foundation(20232ACB206062);Jiangxi Provincial Department of Education(GJJ2400823);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202207);Young Jinggang Scholar of Jiangxi Province(Jing Zhang)and New Century Talents Project of Jiangxi Province(2017082,Xiang Li and 2020028,Jing Zhang);the Science and Technology Innovation Team of Jiangxi University of Chinese Medicine(CXTD22001 and CXTD22006);Jiangxi University of Traditional Chinese Medicine Special Zone Construction Project of Traditional Chinese Medicine(New Drug Creation Direction)(TQ-20).
Recently,immunotherapy has redefined cancer treatment by promoting the rapid killing of tumor cells through the immune system.Herbal medicines have been increasingly used as adjunct therapies to complement cancer trea...
关键词：ANTI-TUMOR Herbal components Immune system Nanodrug delivery systems 
Approved natural products-derived nanomedicines for disease treatment被引量：1
《Chinese Journal of Natural Medicines》2024年第12期1100-1116,共17页LI Xiaotong LAI Yaoyao WAN Guanghan ZOU Jiahui HE Wei YANG Pei 
supported by the National Natural Science Foundation of China(Nos.82073782 and 82241002);the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine(No.zdsys-202103)。
In recent years,there has been an increasing emphasis on exploring innovative drug delivery approaches due to the limitations of conventional therapeutic strategies,such as inadequate drug targeting,insufficient thera...
关键词：NANOMEDICINE Drug carriers Natural properties DIAGNOSIS Disease treatment Safety 
Advancements in drugs restructured with nanomedicines for multiple myeloma treatment被引量：1
《Science China Materials》2024年第12期3780-3795,共16页Zhaoyun Liu Hongli Shen Hui Liu Kai Ding Jia Song Jingtian Zhang Dan Ding Rong Fu 
supported by the National Natural Science Foundation of China Youth Project(81900131);Tianjin Municipal Natural Science Foundation(18JCQNJC80400);Tianjin Education Commission Research Project(2018KJ043);Tianjin Education Commission Research Project(2018KJ045);Tianjin Science and Technology Planning Project(20YFZCSY00060);Tianjin Municipal Health Commission Youth Project(TJWJ2021QN001);the Medjaden Academy&Research Foundation for Young Scientists(MJR20221011);Tianjin Key Medical Discipline(Specialty)Construction project(XZDXK-028A);Tianjin Municipal Health Health Science and Technology Project(TJWJ2023XK003).
Multiple myeloma(MM)is an incurable malignancy of clonal plasma cells,characterized by high relapse rates and rapid development of drug resistance.The emergence of proteasome inhibitors has dramatically improved the t...
关键词：plasma cell disease NANOTECHNOLOGY HEMATOLOGY proteasome inhibitors 
Injectable body temperature responsive hydrogel for encephalitis treatment via sustained release of nano-anti-inflammatory agents
《Biomaterials Translational》2024年第3期300-313,共14页Yuqi Gai Huaijuan Zhou Yingting Yang Jiatian Chen Bowen Chi Pei Li Yue Yin Yilong Wang Jinhua Li 
supported by the National Natural Science Foundation of China(Nos.52302343,81825007);Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910025030),Youth Beijing Scholar Program(No.010);Beijing Institute of Technology Teli Young Fellow Program(No.RCPT-20220029);the Beijing Institute of Technology Research Fund Program for Young Scholars(Nos.XSQD-6120220130,XSQD-202213001).
Skull defects are common in the clinical practice of neurosurgery,and they are easily complicated by encephalitis,which seriously threatens the life and health safety of patients.The treatment of encephalitis is not o...
关键词：anti-inflammatory nanomedicines cranial bone defects ENCEPHALITIS injectable hydrogels sustained release 
Therapeutic potentials of peptide-derived nanoformulations in atherosclerosis:present status and future directions
《International Journal of Smart and Nano Materials》2024年第3期610-651,共42页Xue Liu Weijiao Wang Qiang Li Hongtao Niu Weili Zhang 
Atherosclerosis is a severe cardiovascular disease followed by the accumulation of atherosclerotic plaques within the lumen of blood vessels resulting in reduced blood flow thus initiating a series of events.Conventio...
关键词：ATHEROSCLEROSIS anti-atherosclerotic drugs BIOAVAILABILITY peptide-based nanomedicines drug targeting 
Advancements in precision nanomedicine design targeting the anoikis-platelet interface of circulating tumor cells
《Acta Pharmaceutica Sinica B》2024年第8期3457-3475,共19页Manqing Tang Zhijie Zhang Ping Wang Feng Zhao Lin Miao Yuming Wang Yingpeng Li Yunfei Li Zhonggao Gao 
funded by Tianjin University of Traditional Chinese Medicine Startup Funding to Yunfei Li,and supported by Open Projects Fund of Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology,Shandong University(No.2023CCG13,China);funded by National Natural Science Foundation of China(No.82074030).
Tumor metastasis,the apex of cancer progression,poses a formidable challenge in therapeutic endeavors.Circulating tumor cells(CTCs),resilient entities originating from primary tumors or their metastases,significantly ...
关键词：CTCS ANOIKIS PLATELET Cancer stem cell Metastasis Platelet‒CTC interaction Platelet targeting NANOMEDICINES 
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