Advancements in drugs restructured with nanomedicines for multiple myeloma treatment  

纳米材料搭载药物治疗多发性骨髓瘤的研究进展

作　　者：Zhaoyun Liu Hongli Shen Hui Liu Kai Ding Jia Song Jingtian Zhang Dan Ding Rong Fu 刘召云;沈红利;刘惠;丁凯;宋嘉;章经天;丁丹;付蓉

机构地区：[1]Department of Hematology,Tianjin Medical University General Hospital,Tianjin 300052,China [2]Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control,Tianjin 300052,China [3]Tianjin Institute of Hematology,Tianjin 300052,China [4]State Key Laboratory of Medicinal Chemical Biology,Key Laboratory of Bioactive Materials,Ministry of Education and College of Life Sciences,Nankai University,Tianjin 300071,China

出　　处：《Science China Materials》2024年第12期3780-3795,共16页中国科学（材料科学）（英文版）

基　　金：supported by the National Natural Science Foundation of China Youth Project(81900131);Tianjin Municipal Natural Science Foundation(18JCQNJC80400);Tianjin Education Commission Research Project(2018KJ043);Tianjin Education Commission Research Project(2018KJ045);Tianjin Science and Technology Planning Project(20YFZCSY00060);Tianjin Municipal Health Commission Youth Project(TJWJ2021QN001);the Medjaden Academy&Research Foundation for Young Scientists(MJR20221011);Tianjin Key Medical Discipline(Specialty)Construction project(XZDXK-028A);Tianjin Municipal Health Health Science and Technology Project(TJWJ2023XK003).

摘　　要：Multiple myeloma(MM)is an incurable malignancy of clonal plasma cells,characterized by high relapse rates and rapid development of drug resistance.The emergence of proteasome inhibitors has dramatically improved the therapeutic effect of MM;however,side effects and drug resistance still negatively affect the survival rate of MM.Nano-medicine has become a promising field for therapeutic innovation owing to its biodegradability and biocompatibility.Nanoparticles(NPs),when combined with MM therapeutic drugs,can reduce side effects,increase treatment efficacy,and alleviate drug resistance,providing a new direction for the treatment of MM.Restructuring drugs with NPs presents an ideal strategy for ongoing studies aimed at more effective therapies.Additionally,clinical nanomedicine research has yielded new opportunities for MM treatment.This review,guided by the development of MM therapeutic drugs,summarizes the past 20 years of research progress and breakthroughs in NP-based systems for treating MM and improving drug targeting ability.多发性骨髓瘤(MM)是一种不可治愈的克隆性浆细胞恶性肿瘤,具有易复发、易耐药的特点.蛋白酶体抑制剂的出现显著提高了MM的治疗效果;然而,其副作用和耐药性问题仍有待解决.纳米材料由于其良好生物降解性和生物相容性,已成为一个很有前途的治疗领域.纳米颗粒(NPs)搭载MM治疗药物,可减少副作用,提高治疗疗效,缓解耐药性,为MM的治疗提供了新的方向.本文以MM治疗药物的发展为线索,综述了过去20年NPs搭载MM治疗药物的研究进展和突破.

关 键 词：plasma cell disease NANOTECHNOLOGY HEMATOLOGY proteasome inhibitors 

分 类 号：R733.3[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]