Advancements in precision nanomedicine design targeting the anoikis-platelet interface of circulating tumor cells  

作　　者：Manqing Tang Zhijie Zhang Ping Wang Feng Zhao Lin Miao Yuming Wang Yingpeng Li Yunfei Li Zhonggao Gao 

机构地区：[1]College of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [2]State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [3]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第8期3457-3475,共19页药学学报（英文版）

基　　金：funded by Tianjin University of Traditional Chinese Medicine Startup Funding to Yunfei Li,and supported by Open Projects Fund of Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology,Shandong University(No.2023CCG13,China);funded by National Natural Science Foundation of China(No.82074030).

摘　　要：Tumor metastasis,the apex of cancer progression,poses a formidable challenge in therapeutic endeavors.Circulating tumor cells(CTCs),resilient entities originating from primary tumors or their metastases,significantly contribute to this process by demonstrating remarkable adaptability.They survive shear stress,resist anoikis,evade immune surveillance,and thwart chemotherapy.This comprehensive review aims to elucidate the intricate landscape of CTC formation,metastatic mechanisms,and the myriad factors influencing their behavior.Integral signaling pathways,such as integrin-related signaling,cellular autophagy,epithelial-mesenchymal transition,and interactions with platelets,are examined in detail.Furthermore,we explore the realm of precision nanomedicine design,with a specific emphasis on the anoikis‒platelet interface.This innovative approach strategically targets CTC survival mechanisms,offering promising avenues for combatting metastatic cancer with unprecedented precision and efficacy.The review underscores the indispensable role of the rational design of platelet-based nanomedicine in the pursuit of restraining CTC-driven metastasis.

关 键 词：CTCS ANOIKIS PLATELET Cancer stem cell Metastasis Platelet‒CTC interaction Platelet targeting NANOMEDICINES 

分 类 号：R730.51[医药卫生—肿瘤]