Therapeutic potentials of peptide-derived nanoformulations in atherosclerosis:present status and future directions  

作　　者：Xue Liu Weijiao Wang Qiang Li Hongtao Niu Weili Zhang 

机构地区：[1]Department of Cardiovascular Medicine,Yantaishan Hospital,Yantai,China [2]Department of Otolaryngology,Yantaishan Hospital,Yantai,China [3]Department of Geriatric Medicine,Yantaishan Hospital,Yantai,China

出　　处：《International Journal of Smart and Nano Materials》2024年第3期610-651,共42页国际智能和纳米材料杂志（英文）

摘　　要：Atherosclerosis is a severe cardiovascular disease followed by the accumulation of atherosclerotic plaques within the lumen of blood vessels resulting in reduced blood flow thus initiating a series of events.Conventional therapies for atherosclerosis encounter multiple chal-lenges,especially difficulty in precisely concentrating in certain affected regions and the potential for unwanted side effects.Consequently,scientists are focused on developing nanoformulations for atherosclerosis diagnosis and therapy.Peptide-based nanomedi-cines improve conventional therapies by offering improved structural and therapeutic stability and enabling target-specific delivery.Their inherent biocompatibility and biodegradability additionally render them desirable materials intended for in vivo use.This review manu-script aims to provide an in-depth overview of peptide-based nano-medicines for atherosclerosis,focusing on targeted cells like endothelial cells,macrophages,and monocytes and their interaction with different plaque components.Moreover,the manuscript also highlights the latest progress in multimodal techniques and provides a comprehensive overview of limitations associated with their practical implementation.

关 键 词：ATHEROSCLEROSIS anti-atherosclerotic drugs BIOAVAILABILITY peptide-based nanomedicines drug targeting 

分 类 号：TB383[一般工业技术—材料科学与工程]