ANTI-TUMOR

作品数:366被引量:1036H指数:14
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相关领域:医药卫生更多>>
相关作者:李瑞赵浩如林以宁张晗星李彦更多>>
相关机构:北京大学中国药科大学重庆医科大学山东大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>
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Ce6-GFFY is a novel photosensitizer for colorectal cancer therapy
《Genes & Diseases》2025年第2期304-318,共15页Wei Qiao Shuxin Li Linna Luo Meiling Chen Xiaobin Zheng Jiacong Ye Zhaohui Liang Qiaoli Wang Ting Hu Ling Zhou Jing Wang Xiaosong Ge Guokai Feng Fang Hu Rongbin Liu Jianjun Li Jie Yang 
supported by grants from the National Natural Science Foundation of China (No.82373174,82002466,82202907).
Photodynamic therapy is an"old"strategy for cancer therapy featuring clinical safety and rapid working,but suitable photosensitizers for colorectal cancer therapy remain lacking.This study synthesized a novel photosen...
关键词:Anti-tumorimmunity Ce6-GFFY Colorectal cancer Novel photosensitizer Photodynamic therapy 
Analysis of 979 cases of adverse drug reactions induced by antineoplastic drugs
《Journal of Chinese Pharmaceutical Sciences》2025年第3期223-231,共9页Xingnong Xu Doudou He Lei Ma 
Collaborative Innovation Program of Jiangsu Pharmaceutical Vocational College(Grant No.20239120)。
The aim of this study is to evaluate the characteristics and patterns of adverse drug reactions(ADRs)associated with antineoplastic drugs and provide insights for safer chemotherapy practices.Based on 979 ADR cases re...
关键词:Anti-tumor drugs Adverse effects Drug safety 
Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions
《Fundamental Research》2025年第1期296-306,共11页Yan Zhang Dou Du Chao Fang Xin Yu Yujia Fang Xinyu Liu Di Ou Haohao Yin Hui Liu Taixia Wang Lu Lu Xiaolong Li Kun Zhang 
supported by the Excellent Young Scientists Fund of National Natural Science Foundation of China(82022033);National Natural Science Foundation of China(81901753 and 82001820);Shanghai Rising-Star Program(19QA1406800);Shanghai Talent Development Fund(2019040);the Fundamental Research Funds for the Central Universities(22120210561);the program for Shanghai Young Top-Notch Talent.
Post-transcriptional epigenetic modifications provide numerous implications for tumor progression,metastasis and recurrence,which also pose resistances to reactive oxygen species(ROS)-based anti-tumor.Herein,we propos...
关键词:Epigenetics engineering Ubiquitylation modulation SONOCATALYSIS Reactive oxygen species resistance Anti-tumor action 
Anti-tumor,Anti-inflammatory,and Antibacterial Effects of Isobavachalcone and Their Molecular Mechanisms
《Medicinal Plant》2025年第1期78-80,共3页Hongxue LIANG Wenshuang HOU Xichun HUANG Lei JIANG Chenghao JIN 
Supported by the Key Research and Development Plan Guidance Project of Heilongjiang Province(GZ20220039);Central Support for Local Universities Reform and Development Fund Talent Training Project(2020GSP16).
In this paper,the anti-tumor,anti-inflammatory,antibacterial and anti-asthma effects of isobavachalcone and their molecular mechanisms were reviewed to provide theoretical support for further research of isobavachalco...
关键词:Isobavachalcone ANTI-TUMOR ANTI-INFLAMMATION BACTERIOSTASIS ANTI-ASTHMA 
Design,Synthesis and Pharmacological Evaluation of Novel 4-Phenoxyquinoline Derivatives as VEGFR2 Kinase Inhibitors for Tumor Treatment
《Chemical Research in Chinese Universities》2025年第1期66-78,共13页JIANG Wei CHEN Jiayan WANG Haifeng XUE Aiqi ZHANG Xinyang GUAN Jichi WEI Lulu CAI Jianfeng HU Yong LIU Dan 
supported by the National Natural Science Foundation of China(Nos.52173128,51973091);the Scientific Research Fund of Liaoning Provincial Education Department,China(No.LQ2020021);the Natural Science Foundation of Jiangsu Province(Youth Foundation),China(No.BK20220784).
Vascular endothelial growth factor 2(VEGFR2)plays a vital role in regulating of tumor metastasis and angiogenesis,which has emerged as one of the effective targets for clinical tumor therapy.Herein,a series of novel f...
关键词:ar endothelial growth factor 2(VEGFR2) 4-Phenoxyquinoline Inhibitor ANTI-TUMOR ANGIOGENESIS 
Enhanced antitumor efficacy of fresh pig spleen extracts (PAT) encapsulated with cytidinyl and cationic lipid nanocomplexes
《Journal of Chinese Pharmaceutical Sciences》2025年第1期14-27,共14页Xiaotong Yu Jing Wu Qi Zhang Jiamei Hong Jing Yu Zhu Guan Yanhui Yin Zhenjun Yang 
The Contract Grant from Zhejiang Fengan Biopharmaceutical Co.,Ltd,Zhejiang Province,China。
Traditional Chinese Medicine(TCM)has been utilized in China for thousands of years to treat and prevent various diseases,with recent research highlighting microRNAs(miRNAs)in herbal decoctions as key bioactive compone...
关键词:Extract of pig spleen miRNA DNCA CLD Anti-tumor efficacy 
Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response
《Science China Chemistry》2025年第1期273-287,共15页Shuguang Yang Lijun Hu Hong Xiao Zecong Xiao Xintao Shuai 
supported by the Key Areas Research and Development Program of Guangzhou(202007020006);the National Natural Science Foundation of China(51933011,31971296,82102194,82302360);the Science and Technology Projects of Guangzhou(2023A03J0215);the Guangdong Basic Research Center of Excellence for Functional Molecular Engineering。
Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy.Nonetheless,the optimization of the catal...
关键词:fluorescent molecular probes self-amplifying MYELOPEROXIDASE photodynamic therapy 
Anti-tumor drug supervision in China from2010 to 2024:the evolution and prospect of drug review standards
《Cancer Communications》2025年第1期63-67,共5页Ling Tang Yuanyuan Song Hong Zhang Ruimin Hao Xin Tong Xing Ai Jun Ma Zhimin Yang 
1 BACKGROUND Over the past decade,the research and development(R&D)of anti-tumor drugs in China has undergone a remarkable leap,maintaining a high level of motivation.
关键词:DRUGS EVOLUTION MOTIVATION 
Traditional Chinese medicine-based drug delivery systems for anti-tumor therapies被引量:1
《Chinese Journal of Natural Medicines》2024年第12期1177-1192,共16页YANG Ling WANG Yani YE Xietao LIU Qiaoming QU Ding CHEN Yan 
supported by the National Natural Science Foundation of China (Nos. 82374045, 82173985);the Jiangsu Province Leading Talent Project (No. CZ2023SLJ0302);the National Natural Science Foundation of China (No. 82173980);Jiangsu Province Key Research and Development Program for Social Development Project (No. BE2023788);the Jiangsu Clinical Innovation Center of Digestive Cancer of Traditional Chinese Medicine (No. 2021.6)。
The treatment of tumors continues to be significantly challenging. The presence of multiple modalities, including surgery, radiation, chemotherapy and immunotherapy, the therapeutic outcomes remain limited and are oft...
关键词:Traditional Chinese medicine Nano drug delivery systems Organic-inorganic nanocarriers 
Regulated cell death-amplified sonodynamic anti-tumor immune nanotherapeutics
《BMEMat(BioMedical Engineering Materials)》2024年第4期95-110,共16页Liqiang Zhou Yangmengfan Chen Dong Xie Kun Li Xinwu Cui Christoph F.Dietrich Andreas K.Nussler Xuanjun Zhang 
This work was supported by the Science and Technology Development Fund,Macao SAR(File No.:0032/2023/ITP1);the Ministry of Education Frontiers Science Centre for Precision Oncology,University of Macao(SP2023-00001-FSCPO and FHS-FSCPO/011/2023);the National Natural Science Foundation of China(82302369).
Nanomedicine-assisted sonodynamic therapy(SDT)has emerged as one of the most promising cancer therapies due to its unique advantages of high pene-tration,non-radiation,and excellent oxidative stress effect,but has alw...
关键词:apoptosis sensitization immune activation regulated cell death sonodynamic therapy 
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