Ce6-GFFY is a novel photosensitizer for colorectal cancer therapy  

作　　者：Wei Qiao Shuxin Li Linna Luo Meiling Chen Xiaobin Zheng Jiacong Ye Zhaohui Liang Qiaoli Wang Ting Hu Ling Zhou Jing Wang Xiaosong Ge Guokai Feng Fang Hu Rongbin Liu Jianjun Li Jie Yang 

机构地区：[1]Department of Endoscopy,State Key Laboratory of Oncology in South China,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,China [2]State Key Laboratory of Oncology in South China,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,China [3]Department of Nuclear Medicine,State Key Laboratory of Oncology in South China,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,China [4]Department of Oncology,Affliated Hospital of Jiangnan University,Wuxi,Jiangsu 214062,China [5]Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering,Biomaterials Research Center,School of Biomedical Engineering,Southern Medical University,Guangzhou,Guangdong 510515,China [6]Department of Ultrasound,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510120,China [7]Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Sun Yatsen Memorial Hospital,Sun Yat-Sen University,Guangzhou,Guangdong 510120,China

出　　处：《Genes & Diseases》2025年第2期304-318,共15页基因与疾病(英文)

基　　金：supported by grants from the National Natural Science Foundation of China (No.82373174,82002466,82202907).

摘　　要：Photodynamic therapy is an"old"strategy for cancer therapy featuring clinical safety and rapid working,but suitable photosensitizers for colorectal cancer therapy remain lacking.This study synthesized a novel photosensitizer termed Ce6-GFFY based on a self-assembling peptide GFFY and a photo-responsive molecule chlorin e6(Ce6).Ce6-GFFY forms macroparticles with a diameter of~160 nm and possesses a half-life of 10 h,as well as an ideal tumor-targeting ability in mouse models.Ce6-GFFY effectively penetrates cells and generates numerous reactive oxygen species upon 660 nm laser irradiation.The reactive oxygen species promotes the accumulation of cytotoxic T cells and decrease of myeloid-derived suppressor cells in the tumor microenvironment through immunogenic cell death,thus prohibiting the growth of both primary and metastatic tumors after once treatment.This study not only provides a strategy for photosensitizer development but also confirms a promising application of Ce6-GFFY for colorectal cancer therapy.

关 键 词：Anti-tumorimmunity Ce6-GFFY Colorectal cancer Novel photosensitizer Photodynamic therapy 

分 类 号：R73[医药卫生—肿瘤]